gene1 | gene2 | breakpoint_type | drugs | Druggable_predicted | gene_targets | cancer_types_drug | cancer_types_breakpoint | Chimeras | pubmeds_breakpoint |
---|
PRKAR1A | RET | inv(10)(q11q21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | L03357 | 12720532 |
PRKAR1A | RET | inv(10)(q11q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | L03357 | 12720532 |
PRKAR1A | RET | inv(10)(q11.2q21) | RET inhibitors;BLU-667;LOXO-292 | druggable | RET | THCA | THCA | L03357 | 2310396;3078962;7678053 |
PRKAR1A | RET | t(10;17)(q11;q24) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | L03357 | 12720532;2310396;3078962;7519046;7678053 |
TRIM27 | RET | t(6;10)(p22;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | M16029 | 12787916;25204415;25417114 |
ETV6 | ABL1 | ins(12;9)(p13;q34q34) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib | druggable | ABL1 | alltypes,CML | CML | Z35761 | 12823349;19480935 |
ABL1 | ETV6 | ins(9;12)(q34;p13p13) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib | druggable | ABL1 | ALL,alltypes,CML | ALL,CML | Z35761 | 11170285;9365838 |
ETV6 | ABL1 | t(9;12)(q34;p13) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib;AZD0530;Midostaurin | druggable | ABL1;ETV6 | ALL,alltypes,CML,LAML,MPD | ALL,CML,LAML,MPD | Z35761 | 11170285;12161353;12505259;18656692;20589932;24318592;2687768;27229714;28671688;7805037;8168137;8754809;8808688;9365838;9695962 |
NPM1 | RARA | t(5;17)(q32;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | U41743 | 8562957 |
NPM1 | RARA | t(5;17)(q25.1;q21.1) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | U41743 | 10942370;8562957;9989813 |
RARA | NPM1 | t(5;17)(q32;q12) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | U41743 | 8562957 |
NPM1 | RARA | t(5;17)(q35;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | U41743 | 10339585;10942370;8057672;8562957;8819070;8952164;9204984;9989813 |
NPM1 | ALK | ins(5;2)(q35;p23p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes,DLBC | DLBC | D45915;DI348757;HW349670;S82740;U04946 | 20207848 |
NPM1 | ALK | t(2;5)(p23;q35) | Crizotinib;Ceritinib | druggable | ALK | ALL,alltypes,DLBC | ALL,CTCL,DLBC,HL,NEC | D45915;DI348757;HW349670;S82740;U04946 | 10339500;11048978;11380391;11395396;12816858;14576483;15165197;2156548;7662979;7780128;7949120;8122112;8611713;8633037;8701985;8781433;8781434;8859196;8915313;9057650;9078287;9121481;9209648;9886332 |
TPM3 | NTRK1 | t(1;1)(q21;q23) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib;Pazopanib | druggable | NTRK1;TPM3 | alltypes,COADREAD,GBM,LGG,LUAD,SARC | CESC,COADREAD,GBM,IMT,LGG,LUAD,OV,PAAD,PRAD,SARC,STAD | M55336;M55337 | 24705251;25204415;25500544;26001971;26863915;26892443;27259011;28097808;28877062;30276917 |
TPM3 | NTRK1 | inv(1)(q21q23) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | M55336;M55337 | 1384673;1695324;22895193;2869410;7590742 |
TPR | NTRK1 | t(1;1)(q23;q31) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib;Pazopanib | druggable | NTRK1 | alltypes,COADREAD,LUAD,SARC | CESC,COADREAD,IMT,KICH,LUAD,OV,PAAD,PRAD,SARC,STAD | X62947 | 26001971;27259011;28097808;29915264;30276917 |
TPR | NTRK1 | inv(1)(q23q31) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | X62947 | 10074915;15805251;8288244;9172002 |
RET | NCOA4 | t(10;10)(q11;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | S71225;S74821;S82976;S83049 | 25500544;26078337;27683183 |
NCOA4 | RET | inv(10)(p11q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | S71225;S74821;S82976;S83049 | 23150706 |
NCOA4 | RET | inv(10)(q11q21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | S71225;S74821;S82976;S83049 | 12720532 |
NCOA4 | RET | t(10;17)(q11;q24) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | S71225;S74821;S82976;S83049 | 12720532 |
NCOA4 | RET | inv(10)(q11q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD,TGCT | S71225;S74821;S82976;S83049 | 10597232;11443191;12720532;16405408;22895275;23150706;8290261;8634704 |
EWSR1 | ERG | ins(22;21)(q12;q22q22) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 18295659 |
EWSR1 | ERG | der(22)(q12) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 16006796 |
ERG | EWSR1 | ins(21;22)(q22;q12q12) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 9071576 |
ERG | EWSR1 | t(21;22)(q22.2;q12.2) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 8707406 |
EWSR1 | ERG | t(21;22)(q21;q12) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 10209495;10561219;11441341;20308673;7524604;8040301;8076344;8162068;8223458;9586882;9706984 |
ERG | EWSR1 | t(21;22)(q22;q12) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | 10209495;10561219;11441341;16006796;20308673;7524604;8040301;8076344;8162068;8223458;8707406;9586882;9706984 |
EWSR1 | ERG | ins(21;22)(q22;q12) | YK-4-279;Eribulin;Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | ERG;EWSR1 | SARC | SARC | S72621;S72622;S72865;S73762;S82335;S82338 | |
EWSR1 | WT1 | t(11;22)(p13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | S74529;S79672 | 10208465;12023587;12296765;12640103;15371955;17325488;18561179;20739766;7587063;7862627;8187063;8522311;8540602;9354795;9646031 |
MN1 | ETV6 | t(12;22)(p13;q12) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | LAML,MPD | X85024;X85025;X85026;X85027 | 10931009;11442509;15334551;17476096;21600651;7731705 |
NTRK1 | TFG | t(1;3)(q22;q12) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes | NEC | X85960 | 16946010 |
TFG | NTRK1 | t(1;3)(q21;q11) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes | KIRP | X85960 | 7565764 |
TFG | NTRK1 | t(1;3)(q23;q12) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | X85960 | 7565764;9169129 |
NTRK1 | TFG | t(1;3)(q23.1;q12.2) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes | KIRP | X85960 | 7565764 |
EWSR1 | DDIT3 | ins(22;12)(q12;q13q14) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | X92120 | 12876210 |
DDIT3 | EWSR1 | der(12)(q13) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | X92120 | 11229517 |
DDIT3 | EWSR1 | t(12;22)(q13.3;q12.2) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | X92120 | 10914725;11229517;12169678;16884691;9306965;9315104 |
DDIT3 | EWSR1 | t(12;22)(q13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | X92120 | 10914725;11229517;12169678;9306965 |
COL1A1 | PDGFB | der(22)(?)t(17;22)(?) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 17950782 |
COL1A1 | PDGFB | der(22)(?)t(17;22)(q21;q13) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 10072161 |
COL1A1 | PDGFB | r(17;22)(q21;q13) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 17950782;8988177;9739023 |
COL1A1 | PDGFB | t(17;22)(q21.33;q13.1) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 11329146;12034531;17950782;8988177;9771975 |
COL1A1 | PDGFB | t(17;22)(q21;q13) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 12502925;12641779;12660034;15681532;17950782;19890351;21570152;8988177;9739023 |
COL1A1 | PDGFB | t(17;22)(q22;q13) | Imatinib | druggable | COL1A1;PDGFB | SARC | SARC | X98707;X98708;X98709;X98710;Y08643;Y15913;Y15914;Y15915;Y15916;Y15917;Y15918;Y15919;Y15920;Y15921;Y16341;Y16342;Y16343;Y16344;Y16345;Y16346 | 15681532;17950782;7495279;8988177 |
KMT2A | MLLT3 | der(11)(q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 20451454;23008312 |
MLLT3 | KMT2A | inv(16)(p13q22) | Daunorubicin | druggable | KMT2A | LAML | LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 20451454 |
MLLT3 | KMT2A | ins(9;11)(p21;q13q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 18474298 |
KMT2A | MLLT3 | ins(9;11)(p21;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 15188459 |
KMT2A | MLLT3 | ins(11;9)(q23;p21p23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 9305600 |
MLLT3 | KMT2A | t(9;11)(p21.3;q23.3) | Daunorubicin | druggable | KMT2A | LAML | LAML,SARC | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 14627986;8630416 |
KMT2A | MLLT3 | t(9;11)(p21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 15468339;20451454;21900057;22845170;23008312;23045605;23531517;25500544;7948964;8180386;8402620;8414510;8506309;8630416;8934541;9593289 |
MLLT3 | KMT2A | t(9;11)(p22;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AJ000161;AM050804;AY282394;AY282395;AY282396;AY282398;AY282400;AY282402;AY282403;AY282404;AY282405;AY387662;AY387663;AY840545;AY840546;AY840547;AY840548;AY840550;EF406122;EU669177;S79541;S82034 | 0;10861294;11066077;12619163;14627986;15381384;1602790;16424875;16511515;18000862;2177642;7656208;8506309;8703835;8934541;9331569;9844920 |
ETV4 | EWSR1 | t(17;22)(q21.31;q12.2) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AB005538;HW906201;U35622 | 9858836 |
EWSR1 | ETV4 | t(17;22)(q21;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AB005538;HW906201;U35622 | 8605035;8834175;9738976 |
PAX3 | FOXO1 | t(2;13)(q36;q14) | Bortezomib | druggable | FOXO1;PAX3 | SARC | SARC | BC008826;EU446645;JX141474;JX141475;JX141476;U02308;U02368 | 11496344;11556833;12039929;12550764;17527077;17613043;20351326;21254373;22089931;22454413;23526739;23799156;24089019;26756883;27454570;28035744;8221646 |
TENM4 | NRG1 | dic(8;11)(p12;q14) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AF009227 | 10597312 |
TENM4 | NRG1 | t(8;11)(p12;q14) | Lapatinib | druggable | NRG1 | LUAD | BRCA,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AF009227 | 10523851;21622959 |
NUMA1 | RARA | t(11;17)(q13;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | AF012304 | 8618456;9288109 |
BRAF | SND1 | t(7;7)(q32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | JX013981 | 25204415;25417114;25500544;25985019;26314551;28783718 |
BCR | JAK2 | ins(22;9)(q11;p13p24) | Nilotinib;Pembrolizumab | druggable | BCR;JAK2 | alltypes | MPD | JN021381;JN021382 | 23432689 |
BCR | JAK2 | t(9;22)(p24;q11) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib;Imatinib;TKIs;Bosutinib;Sorafenib;AZD0530;Pembrolizumab | druggable | BCR;JAK2 | ALL,alltypes,CML,LAML | ALL,CML,LAML,MPD | JN021381;JN021382 | 16001431;18503828;22384256;22897847;25260694 |
BCR | JAK2 | t(9;22)(p24;q11.2) | Nilotinib;Pembrolizumab | druggable | BCR;JAK2 | alltypes | NEC | JN021381;JN021382 | 16001431 |
BCR | JAK2 | t(9;18;22)(p22;p11;q24) | Nilotinib;Pembrolizumab;AZ-960;Ruxolitinib | druggable | BCR;JAK2 | alltypes,DLBC | DLBC,MPD | JN021381;JN021382 | |
KMT2A | AFF1 | t(4;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,CML,DLBC,GBM,LAML,NB | AF024541;AF024543;AF029698;AF029700;AF031403;AF031404;AF177232;AF177234;AF177235;AF177236;AF177237;AF177238;AF177239;AF397907;AF487904;AF487905;AF487906;AF492831;AF492832;AF492835;AJ000159;AJ235354;AJ235373;AJ235378;AJ408891;AJ408893;AJ408905;AJ408906;AJ408916;AJ408921;AJ408923;AJ408936;AJ408938;AJ408939;AJ408946;AJ408950;AJ408952;AJ430598;AJ430599;AJ430602;AJ430604;AJ430605;AJ430606;AM050737;AM050738;AM050743;AM050744;AM050747;AM050751;AM050752;AM050754;AM050756;AM050757;AM050758;AM050762;AM050764;AM050766;AM050767;AM050768;AM050770;AM050772;AM050773;AM050774;AM050775;AM050777;AM050778;AM050779;AM050780;AM050781;AM050784;AM050785;AM050787;AM050788;AM050792;AM050794;AM050795;AM050796;AM050799;AM050802;AM050806;AM949685;AM949686;AM949687;AM949688;AM949690;AM949691;AM949692;AM949694;AM949695;AM949700;AM949703;AM949704;AM949706;AM949707;AM949708;AM949709;AM949711;AM949713;AM949714;AM949715;AM949719;AM949728;AM949729;AM949731;AM949733;AM949734;AM949735;AM949736;AM949738;AM949739;AM949740;AM949742;AM949746;AM949749;AM949750;AM949751;AM949752;AM949753;AY288757;AY288760;AY288761;AY288762;AY288766;AY288767;AY288768;AY288769;AY288771;AY288772;AY288773;AY839739;AY839740;AY839741;AY839742;AY839743;AY839745;AY839746;AY839747;AY839751;AY839753;AY839754;DQ284496;DQ284497;DQ284498;DQ451148;FM177515;JN169752;KT444624;KT444627;KT444628;KT444629;KT444630;KT444631;KT444632;L22179;MH401087;MH746808;S48045;S67825;S79285;X83605;Y16604;Y16605;Y16607;Y16608 | 10416593;10773450;11167741;11420702;11493704;11886378;11930009;12791662;12972812;1423625;15650057;16123216;16424875;16511515;17039234;17039237;17287854;17407135;17889710;19141862;19144982;19459927;1991161;20016535;20107154;21354057;21935650;23349309;23628958;24415536;26410102;27265895;27428428;28790105;3496135;7579356;7689231;7748964;7794749;7827204;8161794;8162575;8180386;8219184;8358709;8378328;8414518;8443374;8506309;8703835;9250788;9680349;9731046 |
ASPSCR1 | TFE3 | t(X;17)(p11;q25) | Pazopanib;Trabectedin | druggable | TFE3;ASPSCR1 | SARC | CESC,COADREAD,KICH,KIRC,KIRP,LUAD,NEC,OV,PAAD,PRAD,SARC,SKCM,STAD | AY034077;AY034078;HI518913 | 11244503;11358836;11438465;12769020;15138551;1684532;7656211 |
ETV6 | NTRK3 | ins(12;15)(p13;q25q21) | Midostaurin;Entrectinib;Larotrectinib;Merestinib;Crizotinib;Pazopanib | druggable | ETV6;NTRK3 | SARC,alltypes | SARC | AF041811;AF125808;AF125809;GM682734 | 15262440 |
ETV6 | NTRK3 | ins(12;15)(p13;q22q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | KICH | AF041811;AF125808;AF125809;GM682734 | 12165445 |
ETV6 | NTRK3 | t(12;15)(p13;q25) | Entrectinib;Midostaurin;Larotrectinib;Merestinib;Crizotinib;Pazopanib | druggable | ETV6;NTRK3 | GBM,LAML,LGG,SARC,alltypes | ALL,CESC,COADREAD,GBM,GIST,HES,HNSC,IMT,KICH,KIRC,LAML,LGG,LUAD,LUSC,NEC,OV,PAAD,PRAD,SARC,SKCM,STAD,UVM | AF041811;AF125808;AF125809;GM682734 | 12450787;12450792;12468912;12652616;14528441;14691916;15101049;15826836;16681692;20410810;21226763;21401966;21934478;22895193;23583981;24327398;24705251;25010205;25204415;25417114;25500544;26606880;26647767;27259007;27477320;27824051;28097808;28408464;28719468;29099951;29466156;29900760;30139830;9462753;9694736;9811336;9823307;9949179 |
EWSR1 | ATF1 | t(12;22)(q13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | CESC,COADREAD,LUAD,MESO,NEC,OV,PAAD,PRAD,SARC,SKCM,STAD | AF047022;JF290487;JF290488;JN202448;JN202449;JN624779 | 0;10816241;10849331;11063792;11709699;11826187;11992546;12021921;12218455;15884099;16021514;1606560;16273186;16327442;16517477;17188428;17724745;18094413;18300800;2009504;21185830;21484932;22154050;25359601;28009602;28505004;28559020;28783718;29143432;8223458;8401579;8552387;8637704;9160316;9247632;9306965;9824209 |
AGTRAP | BRAF | t(1;7)(p36;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | HM053972 | 20526349 |
PML | RARA | ins(15;17)(q22;q21q26) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 21529941 |
PML | RARA | der(7)(q?) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 20439630 |
RARA | PML | der(5)(?) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 20439630 |
PML | RARA | der(11)(q23) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 12161368;20439630 |
RARA | PML | inv(16)(p13q22) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 12161368;20439630;22915647 |
RARA | PML | ins(17;15)(q21;q22q22) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 12691149;9389704 |
PML | RARA | t(15;17)(q24;q21) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 1314166;1797083;1848017;2170850;2218500;24160850;26384238;7787753;8515790 |
PML | RARA | ins(15;17)(q22;q21q21) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 10091399;10484977;10552940;10553155;10602411;10609802;10688806;10699936;10702898;10797447;10867154;10874003;10897129;10913680;10942370;10942371;11066449;11068554;11120332;11122887;11172538;11212271;11243116;11358384;11552979;11587362;11593538;11699210;11704847;11704850;11753612;11781220;11807007;11929790;11987921;12060771;12505266;12642682;12691149;12935966;1312695;1320955;1337847;1453773;14612419;14642108;14706140;15124139;15160934;15179005;15223639;15278297;15308013;15359634;15448669;15572690;15604884;15748426;15771903;15860361;15899384;15988048;16056248;16077971;16112651;16132910;16140925;16209039;16228048;16251025;16273555;16330433;16331271;16375665;1650447;16630218;16637276;16638209;16772124;16788101;16835227;16849538;16925116;16928291;17007927;17008891;17172828;17217047;17284374;17286448;17317642;17342318;17361217;17454588;17456159;17459201;17561254;17581672;17688368;17712046;17929112;17934255;17988991;18371732;18445043;18509536;18543226;18558288;18780572;18953948;19041605;19065540;19075265;19109227;19194200;19273155;20155840;7500643;7507700;7519122;7529139;7534109;7536493;7539517;7628753;7638205;7648936;7682097;7697468;7719237;7719245;7759992;7831584;7858239;7858248;7920173;7934155;7935403;7987829;8018944;8095167;8136268;8142621;8144129;8152276;8152308;8161469;8208541;8238249;8260693;8274203;8293467;8296791;8385249;8393784;8394219;8394480;8394752;8395310;8402546;8525772;8536228;8580793;8605120;8605358;8608243;8654368;8674046;8684004;8703836;8721678;8727344;8755206;8773125;8867720;8923791;9002938;9031108;9096691;9096703;9122233;9136977;9156244;9206036;9207466;9209366;9242531;9242568;9354674;9369431;9372085;9389704;9401072;9530334;9531570;9535176;9577647;9636146;9680345;9691124;9694705;9734655;9737682;9772507;9834237;9864917;9864933 |
PML | RARA | t(15;17)(q21;q21) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 12691149;1311253;1652368;1652369;1720570 |
PML | RARA | t(15;17)(q22;q21) | ATRA + arsenic trioxide | druggable | PML;RARA | LAML | ALL,CML,LAML | AB067754;AJ417079;EF535849;M61110;M73779;M82827;S50916;S57796;S57797;S76370;S76372;S76373;S76375;S76379;S76382;S76387;S76389;S76395;S76399;S76402;S76405 | 10221524;10233384;10441338;10942370;10992301;11503965;11516096;11522536;11552979;11916515;12161368;12508246;12619167;12774933;1310153;1353379;1486033;15677559;15899774;16019491;16029447;1652368;1652369;17007927;1720570;17454588;17606455;17960172;18573113;18650449;19100514;19743516;19903674;20439630;20633765;21354057;2170850;22915647;25500544;8139100;8274203;9164186;9354674;9401072;9494608;9609531;9657758;9734655;9792292 |
BCR | ABL1 | ins(22;9)(q11;q21q34) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 26722598 |
ABL1 | BCR | r(9;22)(q34;q11) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 22744847 |
BCR | ABL1 | der(22)(?)t(9;22)(q34;q11)ins(22;9)(q11;q33q33) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 21338279 |
ABL1 | BCR | der(17)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 20409752 |
BCR | ABL1 | del(12)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
ABL1 | BCR | del(13)(q?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120;20409752 |
ABL1 | BCR | del(17)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
ABL1 | BCR | del(7)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
BCR | ABL1 | der(14)(q11) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
BCR | ABL1 | der(7)(p14) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
ABL1 | BCR | der(7)(q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17170120 |
BCR | ABL1 | der(11)(q23) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 17003380;17170120;17241927;18156492;18556413;18633615;19897583;20033052;20409752;20442364;22911440 |
ABL1 | BCR | del(6)(q?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 15650057;17170120 |
ABL1 | BCR | del(9)(q34) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12759927 |
ABL1 | BCR | der(9)(?) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12759927 |
ABL1 | BCR | der(9)(?)del(9)(q34)t(9;22)(q34;q11) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12716364 |
ABL1 | BCR | i(17)(q10) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12684401;15621825 |
BCR | ABL1 | del(7)(q?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12447959 |
ABL1 | BCR | del(9)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12447959;15650057;17170120 |
ABL1 | BCR | der(9)(p?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12447959 |
ABL1 | BCR | dup(1)(q?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12447959 |
ABL1 | BCR | der(22)(?)t(9;22)(?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Ruxolitinib | druggable | ABL1;BCR | ALL,alltypes | ALL | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12239143;12447959 |
ABL1 | BCR | der(22)(?)t(9;22)(q34;q11) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 12176881;12684401;15621825 |
BCR | ABL1 | ins(22;9)(q11;q34q21) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 11369063 |
ABL1 | BCR | der(9)(?)del(9)(q34q34)t(9;22)(q34;q11) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib;Ruxolitinib;TKIs;Sorafenib | druggable | ABL1;BCR | ALL,alltypes,CML | ALL,CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 10648381;11369654;11463449;11535505;11672777;11697340;11902139;12716364;12750153;12759927;12835719;15654903;16616113;16818283;17321324;17456720;17889708;18543309;19145090;21523765 |
ABL1 | BCR | ins(9;22)(q34;q11q11) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 9331565;9723035 |
BCR | ABL1 | ins(22;9)(q11;q34q34) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;AZD0530;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML,LAML | CML,LAML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 11530806;2201832;2237408 |
BCR | ABL1 | t(9;22)(q34;q11) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib;AZD0530;Ruxolitinib;TKIs;Sorafenib | druggable | ABL1;BCR | ALL,alltypes,CML,DLBC,LAML,MPD | ALL,CLL,CML,CTCL,DLBC,LAML,MM,MPD | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 10071072;10198617;10500826;10583263;10586207;10602422;10602428;10706851;10721774;11007054;11021760;11265676;11520571;11745870;12139745;12176881;12239143;12373087;12447959;12684401;12759927;12791662;12886230;14580766;14615910;14635208;1467514;15621825;15650057;15801953;15830009;16203287;16341042;16461299;16467199;16518848;16519699;16523310;16707599;16709931;16775234;16775235;16838024;16908206;16990591;17003380;17039237;17062730;17138817;17151364;17170120;17185463;17189410;17236224;17241927;17264298;17317857;17321991;17325889;17369142;17407135;17429836;17496201;17545610;17607681;17690698;17692911;17715389;17768128;17849425;17876770;17928051;18048643;18055996;18085610;18156492;18165644;18223280;18256322;18348307;18349402;18367490;18543309;18556413;18560751;18633615;18704417;18716134;18754032;18762338;18768781;18776928;1886421;19060245;19062090;19141862;19188180;19211938;19263190;19264678;19266256;19266352;19282457;19282833;1931706;1932753;19369231;19369233;19402171;19449194;19536906;19641300;19641527;19714331;19720924;19729517;19805687;19813250;19816207;19822896;19837975;1985699;19897583;19924787;20008620;20008621;20008622;20010620;20016535;20033052;20131302;20409752;20442364;2050600;20633771;2070054;2070081;2094324;21329980;21365622;2157692;22015493;22019726;2227945;2232886;22887688;22911440;22966847;23989431;24077846;24698424;25049327;25500544;26308885;26385387;2678002;2685476;2747638;27492792;2789335;2820585;2825022;2833755;28935844;29047122;29679774;2989692;2989703;30007093;3027581;3164637;3172839;3259155;3283653;3422329;3422516;3471171;3478595;3479997;3480400;3864009;7579406;7723398;7786776;7934165;7950925;8035604;8083188;8326735;8412311;8426467;8464245;8616789;8667652;8755665;8822944;8839830;8904895;8940193;9050373;9196135;9227927;9250788;9266939;9321394;9332474;9372010;9484838;9566916;9698220;9722319;9731070;9763557;9787174 |
BCR | ABL1 | t(9;22)(?) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib;Ruxolitinib;TKIs;Sorafenib | druggable | ABL1;BCR | ALL,alltypes,CML | ALL,CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | 1317490;1763041;1868241;1900918;2083218;2193202;2263470;2567002;2648256;2678002;2911461;2915904;2989703;3023859;3107980;3194194;3285291;3463934;6281890;6316147;6319012;7063411;7506601;7665185;8453102;8502487 |
BCR | ABL1 | t(9;22)(q34;q21) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | |
ABL1 | BCR | t(9;22)(q34.12;q11.23) | Nilotinib;Imatinib;Bosutinib;Dasatinib;Ponatinib;Asciminib;TKIs;Sorafenib | druggable | ABL1;BCR | alltypes,CML | CML | AB069693;AF113911;AF192533;AF487522;AF533988;AJ131466;AJ131467;AM400881;AM491359;AM491360;AM491361;AM491362;AM491363;AM600680;AM886138;AY043457;AY789120;DQ898313;DQ898314;DQ898315;DQ912588;DQ912589;DQ912590;EF158045;EF423615;EU216059;EU216060;EU216064;EU216066;EU216070;EU216071;EU236680;EU394716;EU394717;EU447303;FN820207;FN820208;FN820209;FN820210;FN820212;FN820213;FN820215;FN820216;FN820217;FN820218;FN820219;FN820221;FN820222;FN820223;FN820224;FN820225;FN820226;FN820227;FN820228;FN820229;FN820230;FN820231;FN820232;FN820233;FN820235;FN820236;FN820237;FN820238;FN820239;FN820240;FN820242;FN820243;FN820244;FN820245;FN820246;FN820247;FN820248;FN820249;FN820250;FN820251;FN820252;FN820255;FN820257;FN820258;FN820261;FN820262;FN820263;FN820264;FN820266;FN820267;FN869132;FN869133;FN869135;FN869136;FN869138;FN869140;FN869141;FN869142;FN869143;FN869144;FN869145;FN869146;FN869147;FN869148;FN869149;FN869151;FN869152;FN869153;FN869156;FN869157;FN869159;FN869160;FN869161;FN869162;FN869163;FN869164;FN869165;FN869166;FN869168;FN869169;FN869171;FN869172;FN869173;FN869174;FN869175;FN869176;JQ425238;JQ425239;JQ425240;JQ425241;JQ425243;JQ425244;JQ425245;JQ425248;JQ425249;JQ425250;JQ425252;JQ425253;KR091980;KR091981;KR091983;KR091984;KR091985;KR091986;KR091987;KR091988;KR091989;KR091990;KR091991;KR091992;KR091993;KR091994;KR091995;KR091996;KR091997;KR091998;KR091999;KR092000;KR092001;KR092002;KR092003;KR092004;KR092005;KR092006;KR092007;KR092008;KR092009;KR092010;KR092011;KR092012;KR092013;KR092014;KR092015;KR092016;KR092017;KR092018;KR092019;KR092020;KR092022;KR092023;KR092024;KT696168;KU234180;KU375572;KU705509;KU705510;M13096;M17541;M19695;M19730;M25946;M31759;MH743144;S72478;S72479;U19399;U19400;U19406;U19408;X06418;X07537 | |
FUS | ERG | t(16;21)(p11;q22) | YK-4-279;Eribulin | druggable | ERG;FUS | SARC | ALL,LAML,NEC,SARC | KY081286;KY081288;KY081289;KY081290;S77574;Y10001 | 10354136;10446493;10523652;10572083;10634649;12907633;1606569;16263589;19737655;2036642;2065316;20694842;2125791;23531517;2357684;27428428;3164243;3860282;7533529;7794765;7970732;8039166;8139114;8187069;8242597;8719898;9096702;9242552;9315104;9549830;9657758 |
GTF2I | RARA | t(7;17)(q11;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | KP100665 | 25284716 |
ETV6 | ACSL6 | t(5;12)(q31;p13) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | CML,LAML,MPD,NEC | AF102845 | 10502316;11861295;16572202;17889716;20107158 |
ACSL6 | ETV6 | t(5;12)(q31.1;p13.2) | Midostaurin | druggable | ETV6 | LAML | LAML | AF102845 | |
HOOK3 | RET | t(8;10)(p11;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | DQ104207 | 17639057 |
TPM3 | ALK | t(1;2)(q21;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,IMT,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,CTCL,IMT,LUAD,OV,PAAD,PRAD,STAD | AF112866;AF362886 | 10216106;10610119;10934142;12707379;24445538;24875859;26647767;26773439;26892443;29329131;29405994 |
SS18 | SSX4 | t(X;18)(p11;q11) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SS18 | SARC | SARC | AF114234;AF257500 | 10359553;10879732 |
TFG | ALK | t(2;3)(p23;q11-q12) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | AF125093;AF143407;AF390891;AF390893 | 11943732 |
TFG | ALK | t(2;3)(p23;q12) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,HNSC,IMT,KIRC,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | CESC,COADREAD,CTCL,HNSC,IMT,KIRC,KIRP,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | AF125093;AF143407;AF390891;AF390893 | 10556217;11943732;18083107;22496456;24875859 |
ALK | TFG | t(2;3)(p23;q21) | Ceritinib;Crizotinib | druggable | ALK | alltypes | NEC | AF125093;AF143407;AF390891;AF390893 | 10381534;10556217;10994999;11090048;11380391 |
ALK | TFG | t(2;3)(p23.2;q12.2) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | AF125093;AF143407;AF390891;AF390893 | |
KMT2A | CBL | t(11;11)(q23;q23.3) | Daunorubicin | druggable | KMT2A | LAML | LAML | AY125965 | 23628958 |
KMT2A | CBL | t(11;11)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AY125965 | 23628958;29279377 |
KMT2A | CBL | del(11)(q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AY125965 | 12696071;16341046 |
KMT2A | USP10 | t(11;16)(q23;q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | MH128093;MH128094 | 30107050 |
ESRP1 | RAF1 | t(3;8)(p25;q22) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | GU149302 | 20526349 |
SLC45A3 | BRAF | t(1;7)(q32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | GU149303 | 20526349 |
SLC45A3 | BRAF | t(1;7)(q32.1;q34) | PLX8394;MEK inhibitors;Sorafenib;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,PRAD,SKCM,STAD | PRAD,SKCM,STAD,UVM | GU149303 | 20526349 |
STRN | ALK | t(2;2)(p22;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | KJ162576 | 24475247;25204415;25417114;26536169;26848800;26933125 |
STRN | ALK | del(2)(p22p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes,HNSC,KIRC,LIHC,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | KJ162576 | 23661334 |
KMT2A | ACTN4 | t(11;19)(q23;q13) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | FM165187;FM165194;FM165195 | 18640063;19144982;19262598;23628958;24561789;25895667;26288717 |
TET1 | KMT2A | t(10;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | FM165188;FM165189;FM165190;FM165191;FM165196;FM165197;FM165198;FM165199 | 12124344;12646957;16341046;16511515;19144982;23100278;23628958;24323992 |
KMT2A | TET1 | t(10;11)(q22;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | FM165188;FM165189;FM165190;FM165191;FM165196;FM165197;FM165198;FM165199 | 12124344;12646957;19144982;9973924 |
NUTM1 | BRD4 | der(15)(q14) | Docetaxel;BET inhibitors;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4;NUTM1 | CESC,HNSC,KIRC,LIHC,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | AY166680 | 15483023 |
BRD4 | NUTM1 | t(15;19)(q13;p13.1) | BET inhibitors;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | HNSC,SKCM | HNSC,SKCM | AY166680 | 11733348;12543779 |
NUTM1 | BRD4 | t(15;19)(q14;p13) | Docetaxel;BET inhibitors;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4;NUTM1 | CESC,HNSC,KIRC,LIHC,LUSC,SKCM,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,SKCM,UCEC | AY166680 | 10944559;11571733;11733348;12543779;12796605;15483023;15994877;16435379;16542442;1785673;2040007;24655834;8374886 |
TMEM91 | TGFB1 | t(19;19)(q13;q13) | LY2109761 | druggable | TGFB1 | LGG | ALL,LGG | BE170483 | 25500544;28671688 |
ETV6 | BAZ2A | t(12;12)(p13;q13) | Midostaurin | druggable | ETV6 | LAML | ALL,CML,LAML | AM181353 | 12393285;16643428;18068531 |
TPM4 | ALK | t(2;19)(p23;p13) | Ceritinib;Crizotinib | druggable | ALK | alltypes,DLBC,IMT | CTCL,DLBC,IMT,NEC | AF186110;AF310722 | 10934142;11493472;16213362;24875859;26647767 |
ALK | TPM4 | t(2;19)(p23;p13.1) | Ceritinib;Crizotinib | druggable | ALK | alltypes | NEC | AF186110;AF310722 | 10383129;10934137 |
KMT2A | EP300 | t(11;22)(q23;q13) | Daunorubicin | druggable | KMT2A | LAML | DLBC,LAML | AY187920 | 20980053;9389684 |
KMT2A | EPS15 | t(1;11)(p32;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AY187922 | 10723246;11986937;12957285;14704037;15721641;16511515;16826222;19322738;19665789;19814798;20519822;21900057;23628958;2713498;3118100;3257157;3471701;3942833;7756657;8134107;9041173;9509513;9593290 |
TMPRSS2 | ETV1 | del(21)(q22q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204770;DQ204771;EU090249 | 16254181;17334343;18483239 |
ETV1 | TMPRSS2 | t(7;21)(p21.3;q22.3) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | PRAD | DQ204770;DQ204771;EU090249 | 16254181 |
TMPRSS2 | ETV1 | t(21;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204770;DQ204771;EU090249 | 16254181;17334343 |
TMPRSS2 | ETV1 | t(7;21)(p21;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204770;DQ204771;EU090249 | 16254181;17108102;17334343;18483239 |
ERG | TMPRSS2 | der(8)(q?) | PARP inhibitors;DNA-PKc inhibitors | druggable | ERG;TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204772;DQ204773;DQ831522;EF194202;EU090248;EU432099;FJ423744 | 21584900 |
ERG | TMPRSS2 | del(21)(q22q22) | PARP inhibitors;DNA-PKc inhibitors | druggable | ERG;TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204772;DQ204773;DQ831522;EF194202;EU090248;EU432099;FJ423744 | 16254181;16575875;16820092;16951139;16951141;17032499;17043636;17079440;17108102;17172822;17237811;17259299;17334343;17334351;17385188;17390040;17527075;17632455;17637754;17971772;17991527;18065961;18474293;18483239;18500259;18519767;18519769;18676740;19029822;19136943;19151660;19190343;19584163;19734849;20118910;20562851;20693979;21584900;21743434;23918607;24297949 |
ERG | TMPRSS2 | t(21;21)(q22;q22) | PARP inhibitors;DNA-PKc inhibitors | druggable | ERG;TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | DQ204772;DQ204773;DQ831522;EF194202;EU090248;EU432099;FJ423744 | 16254181;16575875;16951141;17032499;17043636;17059688;17079440;17108102;17237811;17259299;17334343;17334351;17385188;17390040;17527075;17632455;17637754;17971772;17991527;18065961;18474293;18483239;18500259;18519767;18519769;19029822;19151660;19190343;19584163;19734849;20118910;20562851;20693979;21584900;21743434;22736790;23918607;24297949;24815454;25252136;29099951 |
TMPRSS2 | ERG | t(7;21)(p21;q22) | PARP inhibitors;DNA-PKc inhibitors | druggable | ERG;TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | DQ204772;DQ204773;DQ831522;EF194202;EU090248;EU432099;FJ423744 | 16254181;17334343;18676740;19136943 |
IGH | BCL2 | der(8)(q24) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 16258503;18024371;19151788;20118770;22002575;25828389 |
IGH | BCL2 | t(3;14;18)(q27;q32;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 15899393;16194898 |
IGH | BCL2 | der(3)(q27) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 15815725;18024371 |
IGH | BCL2 | t(14;18)(q32.33;q21.3) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 9223330 |
IGH | BCL2 | t(14;18)(q32.33;q21.33) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 11781262;3186743 |
IGH | BCL2 | t(14;18)(q32;q21.3) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | DQ205508;X63227;X63232 | 3131717;8916960 |
IGH | BCL2 | t(8;14;18)(q24;q32;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | ALL,DLBC | DQ205508;X63227;X63232 | 10618414;10825742;10828038;11061567;11167744;11172955;11298531;11307316;11572760;11774219;11793448;11911399;11950920;12613529;1419624;15716988;16330451;1747446;17493380;18648008;18665753;2252103;7475272;7590697;7630186;7682098;7734714;7950908;8019967;8461469;8622046;8640906;8647513;8700536;8732086;9432035 |
IGH | BCL2 | t(14;18)(q32;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC,LAML | ALL,CLL,DLBC,HL,LAML,SARC | DQ205508;X63227;X63232 | 11895757;12405909;12529690;12691144;12796378;1390255;1427749;15026372;15215171;1555194;15815725;15894922;16258503;17074591;1711639;17169812;17519619;17652637;18024371;18470485;18940474;19151788;19295547;19471018;1958753;19905895;1999960;20022910;2009372;20118770;20976632;2123067;22002575;2284100;24048795;24687831;2538543;25828389;26200345;2682663;27134111;27766616;2848196;3129686;3874430;3929382;6093263;7579360;7727781;8090743;8174093;9218729;9531597;9547992 |
EWSR1 | FLI1 | der(22)(q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 16006796 |
EWSR1 | FLI1 | del(16)(q?) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 12087464 |
FLI1 | EWSR1 | del(1)(p?) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 12087464 |
EWSR1 | FLI1 | dup(1)(q?) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 12087464 |
FLI1 | EWSR1 | ins(11;22)(q24;q12q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 11890993 |
EWSR1 | FLI1 | t(12;22;22)(q14;p1;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | SARC | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 10493837;8040301 |
EWSR1 | FLI1 | t(11;22)(q24;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel;TK216 | druggable | EWSR1;FLI1 | SARC | GBM,MB,MPNST,NB,NEC,SARC,SKCM | AJ229253;AJ229255;AJ229256;AJ229259;AJ229260;AJ229262;AJ229263;AJ229264;AJ229265;AJ229266;AJ229267;AJ229268;AJ229269;AJ229270;AJ229271;AJ229272;AJ229274;AJ229275;AJ229276;AJ229277;AJ229279;AJ229280;AJ229281;AJ229336;AJ229337;DM166685;FW581412;GN033649;HV752995;HW906199;HZ415906;JB766953;JB771995;JF290489;JF290490;JX266448;JX266450;JX266452;JX266453;JX266454;JX266456;JX266457;JX266458;JX266459;JX266463;JX266464;JX266465;JX266467;JX266468;JX266469;JX266470;JX266471;JX266472;JX266473;JX266474;JX266475;JX266476;JX266477;JX266478;JX266479;JX266480;JX266481;JX266482;JX266484;JX266485;JX266486;JX266487;JX266488;JX266489;JX266490;JX266491;JX266493;JX266494;JX266495;JX266496;JX266497;JX266498;JX266499;JX266500;JX266501;JX266502;JX266505;JX266506;JX266510;JX266511;JX266512;JX266513;JX266514;JX266515;JX266516;JX266518;JX266519;JX266521;JX266522;JX266523;JX266524;JX266526;JX266527;JX266528;LF859357;LV708710;MA648624;MA900099;S62665;S72620 | 0;10088552;10197607;10493837;10561219;10565682;10702401;10897036;10999698;11000339;11349881;11391597;12087464;12170091;12683899;1330877;1522903;15929128;16006796;17163788;17557870;18602673;20308669;20308673;23441188;28199314;3163261;3163262;7503813;7506981;7524604;7542907;7700648;8022439;8040301;8063945;8076344;8223458;8238248;8246959;8307570;8339272;8516324;8577710;8644855;8963622;9135495;9224742;9552022;9559290;9586882;9751743;9808135;9822928 |
FIP1L1 | PDGFRA | del(4)(q12q12) | Imatinib;TKIs | druggable | PDGFRA | CML,HES | ALL,CML,HES,LAML,NEC | AY229892 | 12660384;12842979;14973504;15284118;15772698;17628645;18421057;19466970;21304535;22944561;23232855;23637631;24456122;24669761 |
KMT2A | GAS7 | t(11;17)(q23.3;p13.1) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF231993;AF231994;AF231995;AF231996;AF231997;AF231998;AF231999 | 10706619 |
KMT2A | GAS7 | t(11;17)(q23;p13)der(11)(?) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF231993;AF231994;AF231995;AF231996;AF231997;AF231998;AF231999 | 10706619 |
KMT2A | GAS7 | t(11;17)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF231993;AF231994;AF231995;AF231996;AF231997;AF231998;AF231999 | 10706619;16956839;23628958;9593286 |
KMT2A | MLLT10 | ins(11;10)(q23;p12p15) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 25475940 |
MLLT10 | KMT2A | ins(10;11)(p12;q23q14) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 15899395 |
MLLT10 | KMT2A | ins(10;11)(p12;q14q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 15262427 |
MLLT10 | KMT2A | ins(10;11)(p12;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 12886258;16213369;17074587 |
KMT2A | MLLT10 | ins(11;10)(q23;p12p12) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 12810254;19380030 |
MLLT10 | KMT2A | ins(10;11)(p12;q25q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 12810254 |
KMT2A | MLLT10 | ins(11;10)(q23;p12p?) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 11477655 |
KMT2A | MLLT10 | ins(11;10)(q23;p12p11) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 11477655 |
KMT2A | MLLT10 | ins(10;11)(p12;q23q13) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 11187895;11477655;16111539;16213369;16630339;17074587;17459201 |
MLLT10 | KMT2A | t(10;11)(p12;q14) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 9616163 |
MLLT10 | KMT2A | ins(10;11)(p12;q23q12) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 8896421 |
KMT2A | MLLT10 | t(10;11)(p12;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF242207;AF272375;AF272376;AF272383;AF272384;AF272385;AY187923;DQ525423;KF778381 | 10920186;11135434;11480574;11896537;12810254;16111539;16341046;23634996;25500544;28671688;7564531;7662954;7671224;7888665;9593284;9616163;9657758 |
KMT2A | ELL | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | ALL,CML,LAML,MPD | AF272373;AF272374;DQ437652;DQ437653;DQ437654;DQ437655;S77878;S77880;S77889 | 11157501;12377416;16341046;16990786;18617060;21900057;22927255;23628958;25500544;28671688;29279377;7718874;7991593;9277049;9593285 |
KMT2A | ELL | t(11;19)(q23;p13.1) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF272373;AF272374;DQ437652;DQ437653;DQ437654;DQ437655;S77878;S77880;S77889 | 10920186;12377416;7718874;7991593;8426468 |
EML4 | ALK | t(2;2)(p21;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,IMT,LUAD,LUSC,OV,PAAD,PRAD,STAD | CESC,COADREAD,IMT,LUAD,LUSC,OV,PAAD,PRAD,STAD | AB274722;AB275889;AB374361;AB374362;AB374364;AB374365;AB462411;AB462412;DI348820;EU236948;GU797894;GU797895;HC056544;HC056549;HC056650;HC056652;HC056672;HW349733;JQ828841 | 24277751;24296758;24633422;24875859;25204415;25417114;26933125;28535796;29329131 |
EML4 | ALK | del(2)(p21p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,HNSC,KIRC,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | CESC,COADREAD,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | AB274722;AB275889;AB374361;AB374362;AB374364;AB374365;AB462411;AB462412;DI348820;EU236948;GU797894;GU797895;HC056544;HC056549;HC056650;HC056652;HC056672;HW349733;JQ828841 | 18083107 |
EML4 | ALK | inv(2)(p21p23) | Crizotinib;Ceritinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib | druggable | ALK;EML4 | ALL,alltypes,COADREAD,DLBC,HNSC,IMT,KIRC,LIHC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD,UCEC | ALL,CESC,CLL,COADREAD,CTCL,DLBC,HL,HNSC,IMT,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD,UCEC | AB274722;AB275889;AB374361;AB374362;AB374364;AB374365;AB462411;AB462412;DI348820;EU236948;GU797894;GU797895;HC056544;HC056549;HC056650;HC056652;HC056672;HW349733;JQ828841 | 17625570;18083107;18166835;18320074;18593892;18594010;19147828;19383809;19667264;19671850;19734424;19737969;22124476;22736493;25706305;25723109 |
KMT2A | AFDN | der(11)(q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AY288776;DQ387205;DQ387206;HE805693;S82517;S82519;S82521 | 23008312 |
KMT2A | AFDN | t(6;11;7)(q27;q23;q22) | Daunorubicin | druggable | KMT2A | LAML | LAML | AY288776;DQ387205;DQ387206;HE805693;S82517;S82519;S82521 | 11587234 |
AFDN | KMT2A | t(6;11)(q27;q23.3) | Daunorubicin | druggable | KMT2A | LAML | LAML | AY288776;DQ387205;DQ387206;HE805693;S82517;S82519;S82521 | 8814454 |
KMT2A | AFDN | t(6;11)(q27;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AY288776;DQ387205;DQ387206;HE805693;S82517;S82519;S82521 | 10719372;10738298;10886213;11480574;16341046;16511515;16703585;22927255;23008312;23531517;25500544;8242616;8453597;8630416;8703846;8950979;9349501;9593282;9657758;9679199 |
MSN | ALK | t(X;2)(q12;p23.2) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | AF295078;AF295079;AF295356 | 15297972 |
MSN | ALK | t(X;2)(q11;p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL,NEC | AF295078;AF295079;AF295356 | 10994999;11090048;11310834;11380391;15297972 |
FUS | ATF1 | t(12;16)(q13;p11) | Eribulin | druggable | FUS | SARC | MESO,NEC,SARC | AJ295163 | 0;11063792;12218455;28505004 |
FUS | ATF1 | t(12;16)(?) | Eribulin | druggable | FUS | SARC | SARC | AJ295163 | |
PCM1 | RET | t(8;10)(p22;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AJ297349 | 10741739;10980597 |
KMT2A | GMPS | t(3;11)(q25;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF297746;AF297747;AF297748;AF297749 | 11110714;23628958 |
KMT2A | FRYL | t(4;11)(p12;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,GBM,LAML,MPD,NB | DQ299934;DQ299935;DQ299936;DQ299937;DQ299938;DQ299939;DQ299940 | 14623459;16061630;17854671;18195096 |
SS18 | SSX1 | ins(X;18)(p11;q11q21) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SS18 | SARC | SARC | AB300354;AB300355;AF402618;AF404831;AF500624;AY138487;S79325 | 11433527;9688183 |
SS18 | SSX1 | t(18;X)(q11.21;p11.23) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SS18 | SARC | SARC | AB300354;AB300355;AF402618;AF404831;AF500624;AY138487;S79325 | 12687023;7655467 |
SS18 | SSX1 | t(X;18)(p11;q11) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SS18 | SARC | SARC | AB300354;AB300355;AF402618;AF404831;AF500624;AY138487;S79325 | 10191774;10397263;10718206;10824918;10935649;11433527;11782370;12409719;12469233;15126828;15203764;15257548;15260852;15364967;15725802;16157200;16220269;16286044;17197895;19559255;24022186;27621063;7495284;7539744;7655467;7736791;9428816 |
SSX1 | SS18 | t(X;18)(p11.2;q11.2) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SS18 | SARC | SARC | AB300354;AB300355;AF402618;AF404831;AF500624;AY138487;S79325 | 0;12687023;19559255;7655467;9428816 |
SS18 | SSX2 | t(18;X)(q11.21;p11.21) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SSX2;SS18 | SARC | SARC | AB300356;AF230662;AY138488;AY138489;AY138490;AY138491;AY138493;AY138494;AY138495;S79332;X79200 | 12687023 |
SS18 | SSX2 | t(X;18)(p11.22;q11.2) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SSX2;SS18 | SARC | SARC | AB300356;AF230662;AY138488;AY138489;AY138490;AY138491;AY138493;AY138494;AY138495;S79332;X79200 | 15140553;7655467;7951320;9285793;9428816 |
SSX2 | SS18 | t(X;18)(p11.2;q11.2) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SSX2;SS18 | SARC | SARC | AB300356;AF230662;AY138488;AY138489;AY138490;AY138491;AY138493;AY138494;AY138495;S79332;X79200 | 11368913;12037676;12687023;16814213;18384223;7539744;7655467;7951320 |
SSX2 | SS18 | t(X;18)(p11;q11) | Dacarbazine;Doxorubicin;Ifosfamide;Methotrexate | druggable | SSX2;SS18 | SARC | SARC | AB300356;AF230662;AY138488;AY138489;AY138490;AY138491;AY138493;AY138494;AY138495;S79332;X79200 | 10070316;10397263;10718206;10824918;10935649;10935650;11433527;11782370;12409719;12469233;12683902;14669292;15257548;15364967;15725802;16226798;16430486;17355275;17509396;22743288;24022186;27621063;7495284;7539744;7655467;7736791;7951320;9428816 |
DDIT3 | FUS | der(12)(q13) | Eribulin | druggable | FUS | SARC | SARC | AJ301612;AJ301613;AJ301614;GU933437;S62138;S75762;S75763;X71427 | 11229517 |
DDIT3 | FUS | t(12;16)(q13.3;p11.2) | Eribulin | druggable | FUS | SARC | SARC | AJ301612;AJ301613;AJ301614;GU933437;S62138;S75762;S75763;X71427 | 11162437 |
FUS | DDIT3 | t(12;16)(q13;p11) | Eribulin | druggable | FUS | SARC | NEC,SARC | AJ301612;AJ301613;AJ301614;GU933437;S62138;S75762;S75763;X71427 | 10449603;10828883;11146553;11162437;11229517;11751490;11896599;12477932;1283316;15720420;16414544;17647282;2372777;3779625;7485386;7503811;7533529;7566973;7958914;7987849;8058726;8510758;8913727;8921363;9315104;9676855 |
BCR | PDGFRA | t(4;22)(q12;q11) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib;Imatinib;TKIs;Bosutinib;Sorafenib;AZD0530 | druggable | BCR;PDGFRA | ALL,alltypes,CML,LAML,HES,MPD | ALL,CML,HES,LAML,MPD | AY303970 | 12023981;12944919;20107158;21676437;26095243 |
PDGFRA | BCR | t(4;22)(q12;q11.2) | Nilotinib;Imatinib;TKIs | druggable | BCR;PDGFRA | alltypes,MPD | MPD | AY303970 | 10748292;12023981;12353319;12522257;12542482;12944919;15034867;2536372;8586421;9407086 |
TMPRSS2 | ETV5 | t(3;21)(q27;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | EU314929;EU314930;EU314931;FW581626;FW581627;FW581628;HZ416120;HZ416121;HZ416122;JB772367;JB772368;JB772369;LV708924;LV708925;LV708926;MA648838;MA648839;MA648840 | 18172298;29099951 |
ETV5 | TMPRSS2 | t(3;21)(q28;q22.3) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | PRAD | EU314929;EU314930;EU314931;FW581626;FW581627;FW581628;HZ416120;HZ416121;HZ416122;JB772367;JB772368;JB772369;LV708924;LV708925;LV708926;MA648838;MA648839;MA648840 | 18172298 |
KMT2A | NEBL | t(10;11)(p12;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | MH319861;MH319862 | 20362230;23628958 |
KMT2A | NEBL | ins(10;11)(p12;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | MH319861;MH319862 | 19262598 |
ALK | HIP1 | t(2;7)(p23;q11) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | KF360988 | 24496003;24518094 |
KMT2A | MLLT1 | t(11;19)(q23;p13.3) | Daunorubicin | druggable | KMT2A | LAML | ALL,CML,DLBC,LAML | AF373585;AF373586;AF373587;AM050746;AM050798;AM050801;AM949721;AM949722;AM949723;AM949724;AM949725;AY040555;AY187921;AY839729;AY839733;AY839735;DQ224340;DQ224341;DQ224342 | 10458233;10738298;10920186;11526240;1423624;16341046;16424875;16511515;17145626;19144982;20513125;21831428;22846743;26164398;8180386;8378076;8378328;8426468;8703835;9121396;9250666;9593285 |
KMT2A | MLLT1 | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | ALL,DLBC,LAML | AF373585;AF373586;AF373587;AM050746;AM050798;AM050801;AM949721;AM949722;AM949723;AM949724;AM949725;AY040555;AY187921;AY839729;AY839733;AY839735;DQ224340;DQ224341;DQ224342 | 10458233;10738298;10920186;11526240;1423624;16341046;17145626;20513125;21831428;22846743;26164398;8180386;8378076;8378328;9121396;9250666;9593285 |
PTPN12 | HSP90AA1 | t(7;14)(q11;q32) | Luminespib | druggable | HSP90AA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CN395126 | 24564548 |
KMT2A | CEP170B | t(11;14)(q23;q32) | Daunorubicin | druggable | KMT2A | LAML | LAML | AM422012;AM422013 | 18640063;19100518;19254855;23628958 |
PRKAR1A | RARA | t(17;17)(q21;q24) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML,NEC | EF428110;EF428111 | 17712046 |
SEPTIN6 | KMT2A | ins(X;11)(q24;q13q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 18492691 |
KMT2A | SEPTIN6 | ins(11;X)(q23;q24q22) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 16843108 |
SEPTIN6 | KMT2A | ins(X;11)(q24;q23q13) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 12874781 |
KMT2A | SEPTIN6 | t(11;X)(q23;q23-q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 12096348 |
KMT2A | SEPTIN6 | ins(X;11)(q24;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 11477664;11809673;20206559 |
KMT2A | SEPTIN6 | t(X;11)(q24;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | 11477664;11809673;12096348;12874781;14506700;15761502;16511515;16843108;16897742;18492691;9933140 |
KMT2A | SEPTIN6 | t(2;11)(q37;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF450279;AF512943;AF512944;AF512945;AF512946;AY246171 | |
AKT3 | PVT1 | t(1;8)(q44;q24) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | HNSC,KIRC,LIHC,LUAD,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,UCEC | KJ452456;KJ452457 | 25034695 |
KIF5B | ALK | inv(2)(p21p23) | Ceritinib;Crizotinib;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib;Cabozantinib | druggable | ALK;KIF5B | alltypes,LUAD,LUSC,NSCLC | LUAD,LUSC,NSCLC | AB462413;AB795238 | 19383809 |
KIF5B | ALK | t(2;10)(p23;p11) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib;Cabozantinib | druggable | ALK;KIF5B | alltypes,COADREAD,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD | AB462413;AB795238 | 19383809;21656749 |
KMT2A | PICALM | t(11;11)(q23;q14) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF477006;AF477007 | 23628958 |
PICALM | KMT2A | inv(11)(q14) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF477006;AF477007 | 12461747 |
KMT2A | PICALM | inv(11)(q14q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | AF477006;AF477007 | 12461747;16511515 |
PTEN | KIF20B | t(10;10)(q23;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,HNSC | BI492463 | 29099951 |
CDK6 | KMT2A | t(7;11)(q21-q22;q23) | Palbociclib | druggable | CDK6 | GBM | ALL,GBM,NB | AF492830;AF492834 | 11930009 |
NF1 | ATAD5 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BI494556 | 25500544 |
ETV6 | RUNX1 | t(12;21)(p13;q22) | Midostaurin | druggable | ETV6 | LAML | ALL,LAML | AJ494735;AJ494736;DQ100455;DQ100456;DQ100458;DQ207762;DQ207764;DQ207765;DQ207767;DQ207769;DQ224378;DQ224379;DQ224380;EU364772;MH401092 | 10049054;10049055;10086740;10354132;10483004;10557042;10870481;10910927;10914938;11091202;11106814;11157492;11328289;11328310;11343784;11368451;11432885;11559948;11726315;12048236;12506024;12526921;12621238;14752791;15217836;15289014;15356655;16020107;16157196;16424874;16493009;16763978;16965388;17003380;17215856;18241254;18388178;18556413;18633615;19713226;19998443;20010620;20010621;20010622;20016527;20016534;20016535;20016538;20085575;20409752;20442364;21869842;22521551;22699455;22911440;23636228;24415536;27265895;27428428;27506214;28598545;29064485;29589281;29778230;30115129;7492786;7761424;7780150;8609706;8639909;9163615;9226156;9373267;9389711;9473238;9539781;9628428;9639432;9665191;9823952;9845546 |
SEC31A | ALK | t(2;4)(p23;q21) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,DLBC,IMT,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,DLBC,IMT,LUAD,OV,PAAD,PRAD,STAD | KJ495955 | 16161041;20207848;21109691;24875859;25715771 |
KMT2A | MYO1F | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | AF499605 | 15897884;21620472;23628958 |
NR4A3 | EWSR1 | t(9;22)(q22;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AF524261;S81242 | 8634690 |
NR4A3 | EWSR1 | t(9;22)(q22-31;q11-12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AF524261;S81242 | 8570200 |
EWSR1 | NR4A3 | t(9;22)(q22;q11-12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AF524261;S81242 | 8570200 |
NR4A3 | EWSR1 | t(9;22)(q31;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | AF524261;S81242 | 22743288;23588370;24746215;8570200;8634690 |
FGFR1 | PLAG1 | r(8)(p12q12.1) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,HNSC,THCA | HNSC,KIRP,THCA | EF525170 | 18059337 |
FGFR1 | PLAG1 | r(8)(p11q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,PRAD | PRAD | EF525170 | 18059337 |
FGFR1 | PLAG1 | r(8)(p12q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,PRAD | PRAD | EF525170 | |
MPRIP | NTRK1 | t(17;1)(p11.2;q23.1) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK1 | alltypes,LUAD | LUAD,LUSC,NSCLC | HG532017;KF724384 | 24162815 |
CD74 | NTRK1 | t(5;1)(q32;q23.1) | Crizotinib;Entrectinib;Larotrectinib;Merestinib | druggable | CD74;NTRK1 | alltypes,LUAD | LUAD,LUSC,NSCLC | HG532018;KF724385 | 24162815 |
CREB3L2 | FUS | r(7;16)(q34;p11) | Eribulin | druggable | FUS | SARC | SARC | AJ549093;AJ549094;AJ549095;AJ549096;AJ549097 | 20471519 |
CREB3L2 | FUS | t(7;16)(q33;p11) | Eribulin | druggable | FUS | SARC | SARC | AJ549093;AJ549094;AJ549095;AJ549096;AJ549097 | 15139001;28939748 |
CREB3L2 | FUS | t(7;16)(q34;p11) | Eribulin | druggable | FUS | SARC | SARC | AJ549093;AJ549094;AJ549095;AJ549096;AJ549097 | 12915480;15139001;15640831;17721195;21406083 |
SMARCA4 | C19orf38 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | HNSC | CESC,HNSC | EC558601 | 25500544 |
EWSR1 | NFATC2 | r(20;22)(q11-q13.1;q10-q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | FJ573259;FJ573260;FJ573261 | 19318479 |
NFATC2 | EWSR1 | r(20;22)(q13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | FJ573259;FJ573260;FJ573261 | 19318479 |
EWSR1 | NFATC2 | t(20;22)(q13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | FJ573259;FJ573260;FJ573261 | 19318479;24993903 |
RET | GOLGA5 | t(10;14)(q11;q32) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | HI579037;X15786 | 10741739;24445538 |
SQSTM1 | ALK | t(2;5)(p23.1;q35.3) | Ceritinib;Crizotinib | druggable | ALK | alltypes,DLBC | DLBC | AB583922 | 21134980 |
SQSTM1 | ALK | t(2;5)(p23;q35) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,DLBC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,DLBC,LUAD,NEC,OV,PAAD,PRAD,STAD | AB583922 | 11852044;19502794;19524504;19713972;20153326;20814791;21134980;22078874;25413595;25813404;29329131;29747676 |
TBL1XR1 | RARA | t(3;17)(q26;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | KF589333 | 24782508 |
BCOR | RARA | t(X;17)(p11;q12) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | HM597846 | 20807888 |
BCOR | RARA | t(X;17)(p11;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML,NEC | HM597846 | 20807888;25790901 |
PPFIBP1 | ALK | t(2;10)(p23;p11) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | AB600939;AB795401 | 21430068 |
PPFIBP1 | ALK | t(2;12)(p23;p11) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | AB600939;AB795401 | 21430068;23957430 |
BCR | RALGPS1 | der(22)(?)t(9;22)(q34;q11)ins(22;9)(q11;q33q33) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib | druggable | BCR | ALL,alltypes | ALL | HQ622706 | 21338279 |
BCR | RALGPS1 | t(22;9;9)(q11.23) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib | druggable | BCR | ALL,alltypes | ALL | HQ622706 | |
PDGFRB | CCDC6 | t(5;10)(q32;q21) | Imatinib | druggable | PDGFRB | MPD | CML,HES,MPD | KY623718 | 10910073;11389034;17211520;20107158 |
PDGFRB | CCDC6 | t(5;10)(q33.1;q21) | Imatinib | druggable | PDGFRB | MPD | CML,HES,MPD | KY623718 | 10190953;10910073;11389034;17211520;20107158 |
TFG | ADGRG7 | t(3;3)(q12;q12) | Foretinib | druggable | TFG | LGG | ALL,CESC,COADREAD,GBM,LAML,LGG,LUAD,MM,OV,PAAD,PRAD,STAD | DA624159;DA629346;DB085707;DB089999 | 19797732;22496456;23634996;23917401;26536169;27165744;28512242;28671688;29196615 |
NDRG1 | ERG | t(8;21)(q24;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,NEC,OV,PAAD,PRAD,STAD | FJ627786;FJ627787 | 19649210;20118910;20964841;21036922 |
NDRG1 | ERG | t(8;21)(q24.3;q22.3) | PARP inhibitors | druggable | ERG | PRAD | PRAD | FJ627786;FJ627787 | 19649210 |
PAX3 | NCOA1 | t(2;2)(p23;q36) | Bortezomib | druggable | PAX3 | SARC | SARC | AY633656 | 15313887;19953635;27454570 |
PAX3 | NCOA1 | t(2;2)(q35;p23) | Bortezomib | druggable | PAX3 | SARC | SARC | AY633656 | 15313887;19953635 |
ETV4 | TMPRSS2 | t(17;21)(q21;q22.3) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | PRAD | EU693079 | 18794152 |
TMPRSS2 | ETV4 | del(21)(q22q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | EU693079 | 17079440;17334343;18483239 |
TMPRSS2 | ETV4 | t(17;21)(q21;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | EU693079 | 16585160;17079440;17334343;18483239 |
ETV4 | TMPRSS2 | t(17;21)(q21.31;q22.3) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | PRAD | EU693079 | 16585160 |
ROS1 | EZR | t(6;6)(q22;q25) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698667;AB795246;JB625495 | 24469108;25079552;25204415;25230898 |
EZR | ROS1 | inv(6)(q22q25) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698667;AB795246;JB625495 | 22327623;23426121 |
RET | CCDC6 | t(10;10)(q11;q21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698668;AB698669;AF395885;D90075;KU254649;M31213 | 25204415;25500544;26078337 |
CCDC6 | RET | inv(10)(p11q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698668;AB698669;AF395885;D90075;KU254649;M31213 | 23150706 |
CCDC6 | RET | inv(10)(q11q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698668;AB698669;AF395885;D90075;KU254649;M31213 | 12720532 |
CCDC6 | RET | inv(10)(q11q21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB698668;AB698669;AF395885;D90075;KU254649;M31213 | 11443191;12720532;1384673;1542652;1569189;16595592;22327623;23154560 |
CUX1 | RET | t(7;10)(q22.1;q11.22) | Cabozantinib;Vandetanib;BLU-667;LOXO-292 | druggable | RET | LUAD,NSCLC | LUAD,LUSC,NSCLC | AB703464;AB703465;KF421948 | |
ETV6 | PRDM16 | t(1;12)(p36;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | FR719953 | 22050763 |
PAX3 | MAML3 | t(2;4)(q35;q31.1) | Bortezomib | druggable | PAX3 | SARC | SARC | KF727276;KF727277 | 24859338 |
BCR | FGFR1 | t(8;22)(p11;q11) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib;Imatinib;TKIs;Bosutinib;Sorafenib;AZD0530;AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | BCR;FGFR1 | ALL,alltypes,CML,LAML,PAAD,COADREAD,LUAD,OV,PRAD,STAD | ALL,CESC,CML,COADREAD,LAML,LUAD,MPD,OV,PAAD,PRAD,STAD | AB742170;AB742171;AJ298916;AJ298917;AJ298918 | 11739186;11746971;18615682;20594995;21239058;23171834;24564548;29119847 |
FLNA | KMT2A | ins(X;11)(q28;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | KJ754384;KJ754385 | 25892123 |
FLNA | KMT2A | t(X;11)(q28;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | KJ754384;KJ754385 | 23628958 |
KMT2A | FLNA | ins(11;X)(q23;q28q12) | Daunorubicin | druggable | KMT2A | LAML | LAML | KJ754384;KJ754385 | 19622092;28253492 |
KMT2A | FLNA | ins(11;X)(q23;q13q28) | Daunorubicin | druggable | KMT2A | LAML | LAML | KJ754384;KJ754385 | 19262598 |
PDGFRB | NIN | t(5;14)(q32;q22) | Imatinib | druggable | PDGFRB | MPD | MPD | AY764156;AY764157 | 15087377 |
NIN | PDGFRB | t(5;14)(q33;q24) | Imatinib | druggable | PDGFRB | MPD | CML,HES,MPD | AY764156;AY764157 | 12542482;15087377 |
ALK | KLC1 | t(2;14)(p23;q32) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB781674 | 22347464;28741662 |
KLC1 | ALK | t(2;14)(p23;q32.3) | Ceritinib;Crizotinib;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,LUAD | LUAD | AB781674 | 22347464 |
TPM3 | ROS1 | t(1;6)(q21;q22) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB795239;JB625501 | 22327623;24445538;25742289 |
ROS1 | SDC4 | t(6;20)(q22;q12) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB795240;AB795241;AB795242;JB625487;JB625489;JB625491 | 22327623;22919003 |
SLC34A2 | ROS1 | t(4;6)(p15;q22) | Crizotinib;Crizotinib (ALK/MET/ROS1 TKI) | druggable | ROS1 | alltypes,COADREAD,HNSC,KIRC,LIHC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD,UCEC | CESC,COADREAD,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD,UCEC | AB795243;EU236946;EU236947;FU269871;FU269872;HW611946;HW611947;JB625497;LX092649;LX092650 | 18083107;22327623;22661537;22919003;22975805;24296758 |
CD74 | ROS1 | t(5;6)(q33;q22) | Crizotinib | druggable | CD74;ROS1 | alltypes,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | AB795244;AB795245;EU236945;HI637154;HV688672;HZ779675;JB625493;LQ575605 | 18083107;22327623;22661537;22919003;22975805;22980975;23426121 |
ROS1 | LRIG3 | t(6;12)(q22;q14) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB795247;AB795248;JB625499 | 22327623;25742289 |
KIF5B | RET | t(10;10)(p11;q11) | Cabozantinib;Vandetanib | druggable | KIF5B;RET | LUAD | CESC,COADREAD,HNSC,LUAD,LUSC,OV,PAAD,PRAD,STAD | AB795249;AB795250;AB795251;AB795252;AB795253;AB795254;AB795255;AB795256;AB795257;HW088349;HW088350;HW088351;HW088352;JB417295;JB417297 | 24445538;27683183;28783718 |
KIF5B | RET | inv(10)(p11q11) | Cabozantinib;Vandetanib;BLU-667;LOXO-292 | druggable | KIF5B;RET | LUAD,NSCLC | CESC,COADREAD,HNSC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,SKCM,STAD | AB795249;AB795250;AB795251;AB795252;AB795253;AB795254;AB795255;AB795256;AB795257;HW088349;HW088350;HW088351;HW088352;JB417295;JB417297 | 22194472;22327622;22327623;22327624;22797671;22975805;23052255;23150706;23378251;30653139 |
AKAP9 | BRAF | t(7;7)(q21;q34) | PLX8394;Dabrafenib;PLX-4720;Sorafenib;MEK inhibitors;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,LGG,SKCM | LGG,SKCM,UVM | AY803272;FN170090 | 26314551;29464327 |
AKAP9 | BRAF | inv(7)(q21q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AY803272;FN170090 | 15630448 |
AKAP9 | BRAF | inv(7)(?) | PLX8394;Dabrafenib;PLX-4720;Dabrafenib+Trametinib | druggable | BRAF | alltypes,THCA | THCA | AY803272;FN170090 | 15630448 |
AHCYL1 | FGFR2 | t(1;10)(p13;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AB821309;LP131425 | 24122810 |
FGFR2 | BICC1 | t(10;10)(q21;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | AB821310;LP131423 | 23558953;24122810;24550739;24563076;28783718 |
PAX7 | FOXO1 | t(1;13)(p36;q14) | Bortezomib | druggable | FOXO1 | SARC | NEC,SARC | HQ824715 | 10439042;10491019;10700864;11063797;11452933;11496344;11556833;11607823;11807989;12039929;1283318;15688409;16365729;16607381;1663783;16645206;16849537;17311532;17527077;17613043;1777415;18701482;19147825;19422036;21254373;22089931;22447499;22454413;23526739;26756883;28035744;8187070;8789435;8826957;9164192;9223312;9482420 |
FGFR3 | TACC3 | del(4)(p16p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,HNSC | CESC,HNSC | JE837674;JE837676;JE837680;JE837682 | 23661334 |
FGFR3 | TACC3 | t(4;4)(p16.3;p16.3) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074;FGFR inhibitors | druggable | FGFR3 | alltypes,BLCA | BLCA | JE837674;JE837676;JE837680;JE837682 | 23298836;24121792;25294908;25535896;26425723;27345413 |
FGFR3 | TACC3 | t(4;4)(p16;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074;FGFR inhibitors | druggable | FGFR3;TACC3 | alltypes,BLCA,COADREAD,GBM,HNSC,KIRC,LGG,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | BLCA,CESC,COADREAD,GBM,HNSC,KIRC,KIRP,LGG,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | JE837674;JE837676;JE837680;JE837682 | 22837387;23175443;23558953;23583981;23917401;24120142;24121792;24261984;24508317;25204415;25294908;25500544;25535896;25609060;26373574;26425723;26869289 |
FGFR3 | BAIAP2L1 | t(4;7)(p16;q22) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074;FGFR inhibitors | druggable | FGFR3 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | JE837678;JE837684 | 23175443;23558953 |
INSL6 | JAK2 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BF890967;BF890982;BI025699 | 27907167 |
KMT2A | TCF12 | t(11;15)(q23;q21) | Daunorubicin | druggable | KMT2A | LAML | LAML | JF938533 | 28701730 |
GCC2 | ALK | t(2;2)(p23;q12) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | KU954549 | 28741662;29290262 |
ALK | PHACTR1 | t(2;6)(p23;p24) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | KU954551 | 28741662 |
KIAA1217 | RET | t(10;10)(p12;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | KU954552 | 27150058 |
KMT2A | MAML2 | inv(11)(q21q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | AJ972402;DQ084492;DQ084493;DQ084494;DQ886023;DQ886024;EF139426;EF139427;KY584083 | 17551948;18337764;25031740 |
KMT2A | MLLT6 | t(11;17)(q23;q12) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | MH973313;MH973314;S72604 | 15676155;16105757;16511515;16897742;21252984;21900057;23531517;23628958;26952838;28671687;28671688;8058765 |
MLLT6 | KMT2A | t(11;17)(q23;q21) | Daunorubicin | druggable | KMT2A | LAML | LAML | MH973313;MH973314;S72604 | 8058765 |
KIAA1549 | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,GBM,LGG,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,GBM,IMT,KICH,LGG,LUAD,OV,PAAD,PRAD,STAD | AM989472;AM989473;AM989474;AM989475;AM989476;AM989477;FR799512;FR799513;FR799514;FR799516;FR799518;FR799520;FR799521;FR799522;FR799523;FR799524;FR799525;FR799526;FR799529;FR799532;FR799533;FR799534;FR799535;FR799537;FR799541;FR799542;FR799543;FR799546;FR799548;FR799549;FR799550 | 25382612;25500544;26083571;26314551;28783718;29915264 |
KIAA1549 | BRAF | del(7)(q34q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | AM989472;AM989473;AM989474;AM989475;AM989476;AM989477;FR799512;FR799513;FR799514;FR799516;FR799518;FR799520;FR799521;FR799522;FR799523;FR799524;FR799525;FR799526;FR799529;FR799532;FR799533;FR799534;FR799535;FR799537;FR799541;FR799542;FR799543;FR799546;FR799548;FR799549;FR799550 | 25040262 |
KIAA1549 | BRAF | dup(7)(q34q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,GBM,LGG | GBM,LGG | AM989472;AM989473;AM989474;AM989475;AM989476;AM989477;FR799512;FR799513;FR799514;FR799516;FR799518;FR799520;FR799521;FR799522;FR799523;FR799524;FR799525;FR799526;FR799529;FR799532;FR799533;FR799534;FR799535;FR799537;FR799541;FR799542;FR799543;FR799546;FR799548;FR799549;FR799550 | 18974108;19016743;19373855;20454969;21610142;22157620;22591444;22710963;23278243;25720745;26945035 |
DCTN1 | ALK | t(2;2)(p13;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | HQ993071 | 24445538;25813404;28167572 |
DCTN1 | ALK | t(2;12)(p23;q11)t(3;11)(p11;q23) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | HQ993071 | |
KRAS | ETFRF1 | t(12;12)(p12;p12) | Binimetinib;Cobimetinib;Trametinib | druggable | KRAS | alltypes | SKCM,UVM | NM;001001660 | 28783718 |
RAF1 | MTAP | t(3;9)(p25;p21) | Cobimetinib | druggable | RAF1 | SARC | SARC | | 30314519 |
TMF1 | RAF1 | t(3;3)(p14;p25) | Cobimetinib | druggable | RAF1 | SARC | SARC | | 30276917 |
NTRK2 | SPECC1L | t(9;22)(q21;q11) | Entrectinib;Larotrectinib;Merestinib;Pazopanib | druggable | NTRK2 | alltypes,SARC | SARC | | 30276917 |
SLMAP | RAF1 | t(3;3)(p14;p25) | Cobimetinib | druggable | RAF1 | SARC | SARC | | 30276917 |
PDZRN3 | RAF1 | t(3;3)(p13;p25) | Cobimetinib | druggable | RAF1 | SARC | SARC | | 30276917 |
KHDRBS1 | NTRK3 | t(1;15)(p35;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | IMT | | 30187166 |
ABL1 | AIF1L | t(9;9)(q34;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 29726059 |
NUTM1 | CIC | t(15;19)(q14;q13) | Docetaxel | druggable | NUTM1 | CESC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | | 29700887 |
ARHGEF25 | NTRK1 | t(12;1)(q13.3;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1;ARHGEF25 | alltypes,GBM | GBM | | 29617662 |
MLPH | ALK | t(2;2)(p23;q37) | Ceritinib;Crizotinib | druggable | ALK | alltypes | | | 29329131 |
ALK | PRKAR2A | t(2;3)(p23;p21) | Ceritinib;Crizotinib | druggable | ALK | alltypes | | | 29329131 |
JAK2 | MYH9 | t(9;22)(p24;q12) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 29279377 |
ABL1 | ZBTB16 | t(9;11)(q34;q23) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 29279377 |
IKZF1 | NOTCH1 | t(7;9)(p12;q34) | Gamma secretase inhibitors | druggable | NOTCH1 | ALL | ALL | | 29279377 |
IGK | CD74 | t(2;5)(p11;q33) | Crizotinib | druggable | CD74 | alltypes | MM | | 29196615 |
FGFR3 | NOC4L | t(4;12)(p16;q24) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
ATF3 | FGFR3 | t(1;4)(q32;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
NF1 | IGLL5 | t(17;22)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | MM | | 29196615 |
FGFR3 | PIDD1 | t(4;11)(p16;p15) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
FGFR3 | OAZ1 | t(4;19)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
IGK | FGFR3 | t(2;4)(p11;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
FGFR3 | DOT1L | t(4;19)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
JAK2 | IGH | t(9;14)(p24;q32) | Pembrolizumab | druggable | JAK2 | alltypes | MM | | 29196615 |
CD74 | IGH | t(5;14)(q33;q32) | Crizotinib | druggable | CD74 | alltypes | MM | | 29196615 |
FGFR3 | KLF2 | t(4;19)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 29196615 |
EGFR | HMGA2 | t(7;12)(p11;q14) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM | GBM | | 29193056 |
PDGFRB | PCM1 | t(5;8)(q32;p22) | Imatinib | druggable | PDGFRB | MPD | MPD | | 29169164 |
BRAF | GIT2 | t(7;12)(q34;q24) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 29141672 |
P2RY8 | CRLF2 | t(X;X)(p22;p22) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL,LAML | | 29140408 |
FGFR2 | ATE1 | t(10;10)(q26;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BCR | GNAZ | t(22;22)(q11;q11) | Nilotinib | druggable | BCR | alltypes | CESC,HNSC | | 29099951 |
ARHGAP12 | KIF5B | t(10;10)(p11;p11) | Cabozantinib | druggable | KIF5B | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BRAF | CUL1 | t(7;7)(q34;q36) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ARID1A | RPS6KA1 | t(1;1)(p36;p36) | LJI308 | druggable | RPS6KA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CEP170 | AKT3 | t(1;1)(q43;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | SKCM | SKCM,UVM | | 29099951 |
MET | CAV1 | t(7;7)(q31;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TNKS2 | HECTD2 | t(10;10)(q23;q23) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PSMD9 | MAP2K2 | t(12;19)(q24;p13) | PD-0325901;Trametinib | druggable | MAP2K2 | HNSC | CESC,HNSC | | 29099951 |
CASC3 | ERBB2 | t(17;17)(q21;q12) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | HNSC | CESC,HNSC | | 29099951 |
AKT3 | ADSS | t(1;1)(q44;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MIB2 | ACVR1B | t(1;12)(p36;q13) | SB505124 | druggable | ACVR1B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | ERBB3 | t(5;12)(q33;q13) | Crizotinib;Sapitinib | druggable | CD74;ERBB3 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PARP1 | MACROD1 | t(1;11)(q42;q13) | Niraparib;Olaparib;Talazoparib | druggable | PARP1 | SKCM | SKCM,UVM | | 29099951 |
PLPP1 | MAPK1 | t(5;22)(q11;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BEND2 | SMARCA2 | t(X;9)(p22;p24) | PFI-3 | druggable | SMARCA2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
JAK2 | RCL1 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,HNSC | CESC,HNSC | | 29099951 |
NF1 | IKZF3 | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BRCA1 | NF1 | t(17;17)(q21;q11) | Niraparib;Olaparib;Rucaparib;Cobimetinib;Trametinib | druggable | BRCA1;NF1 | OV,alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
WRN | NRG1 | t(8;8)(p12;p12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | ITGB2 | t(5;21)(q33;q22) | Crizotinib | druggable | CD74 | alltypes | CESC,HNSC | | 29099951 |
KIF5B | EPC1 | t(10;10)(p11;p11) | Cabozantinib | druggable | KIF5B | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GRHL2 | ERG | t(8;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
OCIAD1 | KIT | t(4;4)(p11;q12) | Cediranib;Dasatinib;Sorafenib;Imatinib | druggable | KIT | SKCM | SKCM,UVM | | 29099951 |
PTEN | ARHGEF7 | t(10;13)(q23;q34) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
EZH2 | TMEM176B | t(7;7)(q36;q36) | GSK343 | druggable | EZH2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CDK12 | CACNB1 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KCNQ3 | ZHX2 | t(8;8)(q24;q24) | Sorafenib | druggable | ZHX2 | SKCM | SKCM | | 29099951 |
SYK | AUH | t(9;9)(q22;q22) | Entospletinib;PRT062607 | druggable | SYK | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ALK | SCEL | t(2;13)(p23;q22) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CAPZB | CDKN2A | t(1;9)(p36;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | BLCA,KIRC,KIRP | | 29099951 |
ERBB3 | ARHGDIA | t(12;17)(q13;q25) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
KIT | FAR1 | t(4;11)(q12;p15) | Cediranib;Dasatinib;Sorafenib;Imatinib | druggable | KIT | SKCM | SKCM,UVM | | 29099951 |
GSK3A | CNFN | t(19;19)(q13;q13) | SB216763 | druggable | GSK3A | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NTRK1 | DYNC2H1 | t(1;11)(q23;q22) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes | | | 29099951 |
PTEN | SHC2 | t(10;19)(q23;p13) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | SKCM,UVM | | 29099951 |
PLEKHH1 | ERG | t(14;21)(q24;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CA10 | TOP1 | t(17;20)(q22;q12) | Camptothecin;Irinotecan | druggable | TOP1 | HNSC | CESC,HNSC | | 29099951 |
BTBD2 | DOT1L | t(19;19)(p13;p13) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FBXO28 | FGFR3 | t(1;4)(q42;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,LGG | LGG | | 29099951 |
ERBB3 | EEF2 | t(12;19)(q13;p13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NRG1 | STMN2 | t(8;8)(p12;q21) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
IGF1R | WDR93 | t(15;15)(q26;q26) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TOP1 | SLC2A10 | t(20;20)(q12;q13) | Camptothecin;Irinotecan | druggable | TOP1 | HNSC | CESC,HNSC | | 29099951 |
RAF1 | PHC3 | t(3;3)(p25;q26) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ABL1 | SLC38A10 | t(9;17)(q34;q25) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PDE9A | TMPRSS2 | t(21;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
WEE1 | ACLY | t(11;17)(p15;q21) | Adavosertib;MK-1775 | druggable | WEE1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
USP47 | ARID3B | t(11;15)(p15;q24) | P22077 | druggable | USP47 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ALDH3A1 | NF1 | t(17;17)(p11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | SKCM | | 29099951 |
BRD9 | TERT | t(5;5)(p15;p15) | BIBR-1532;I-BRD9 | druggable | TERT;BRD9 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AGTR1 | NF1 | t(3;17)(q24;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,HNSC | | 29099951 |
PIK3CB | SEMA5B | t(3;3)(q22;q21) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SUPT16H | ERBB2 | t(14;17)(q11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ACTG2 | ALK | t(2;2)(p13;p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes | | | 29099951 |
CD74 | TNFRSF6B | t(5;20)(q33;q13) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GSK3B | RASSF2 | t(3;20)(q13;p13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ENPP2 | FGFR2 | t(8;10)(q24;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NARS2 | TOP1 | t(11;20)(q14;q12) | Camptothecin;Irinotecan | druggable | TOP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PAN3 | FLT3 | t(13;13)(q12;q12) | Cediranib | druggable | FLT3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB2 | DNAJC7 | t(17;17)(q12;q21) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TP53 | CHD3 | t(17;17)(p13;p13) | MIRA-1 | druggable | TP53 | SKCM | SKCM,UVM | | 29099951 |
CD74 | SUPT16H | t(5;14)(q33;q11) | Crizotinib | druggable | CD74 | alltypes | DLBC | | 29099951 |
ABCC4 | ERG | t(13;21)(q32;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NOTCH3 | BRD4 | t(19;19)(p13;p13) | Docetaxel;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB2 | TCAP | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | HNSC | CESC,HNSC | | 29099951 |
S100A6 | ERBB3 | t(1;12)(q21;q13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NF1 | RPTOR | t(17;17)(q11;q25) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | | | 29099951 |
ZC3H15 | BRD4 | t(2;19)(q32;p13) | Docetaxel;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NPHP4 | CDKN2A | t(1;9)(p36;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | SKCM,UVM | | 29099951 |
CD74 | NDUFV1 | t(5;11)(q33;q13) | Crizotinib | druggable | CD74 | alltypes | SKCM | | 29099951 |
ARSG | CDK12 | t(17;17)(q24;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FAT1 | NTRK3 | t(4;15)(q35;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | CESC,HNSC | | 29099951 |
SOBP | CDKN2A | t(6;9)(q21;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AKT2 | SRRM5 | t(19;19)(q13;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | LGG | LGG | | 29099951 |
CDK12 | IKZF3 | t(17;17)(q12;q21) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
VRK3 | TGFB1 | t(19;19)(q13;q13) | LY2109761 | druggable | TGFB1 | HNSC | CESC,HNSC | | 29099951 |
PRPS1 | IGF1R | t(X;15)(q22;q26) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SHB | CDKN2A | t(9;9)(p13;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | MESO | | 29099951 |
ALK | DDX6 | t(2;11)(p23;q23) | Ceritinib;Crizotinib;PF2341066 | druggable | ALK | alltypes,SKCM | SKCM | | 29099951 |
AP3D1 | DOT1L | t(19;19)(p13;p13) | EPZ004777;Pinometostat | druggable | DOT1L | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
CDKN2A | EXD2 | t(9;14)(p21;q24) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | BLCA,KIRC,KIRP | | 29099951 |
ATM | CARD18 | t(11;11)(q22;q22) | Olaparib | druggable | ATM | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KIT | SLC4A4 | t(4;4)(q12;q13) | Cediranib;Dasatinib;Sorafenib | druggable | KIT | HNSC | CESC,HNSC | | 29099951 |
GFPT1 | NF1 | t(2;17)(p13;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TRIM33 | CSDE1 | t(1;1)(p13;p13) | Cabozantinib | druggable | TRIM33 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PTEN | GRID1 | t(10;10)(q23;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SMARCA4 | KDM4B | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | HNSC | CESC,HNSC | | 29099951 |
BRD4 | AKAP8L | t(19;19)(p13;p13) | Docetaxel;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SLC1A1 | SMARCA2 | t(9;9)(p24;p24) | PFI-3 | druggable | SMARCA2 | HNSC | CESC,HNSC | | 29099951 |
ERBB3 | TPT1 | t(12;13)(q13;q14) | Sapitinib | druggable | ERBB3 | SKCM | SKCM | | 29099951 |
AFDN | SYK | t(6;9)(q27;q22) | Entospletinib;PRT062607 | druggable | SYK | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PTPRN2 | ABL1 | t(7;9)(q36;q34) | Nilotinib | druggable | ABL1 | alltypes | | | 29099951 |
MTOR | GARNL3 | t(1;9)(p36;q33) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
THRA | CDK12 | t(17;17)(q21;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
EPHB2 | NTRK1 | t(1;1)(p36;q23) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes,LGG | LGG | | 29099951 |
TMPRSS2 | SETD4 | t(21;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ARID1B | IGF1R | t(6;15)(q25;q26) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ACVR1B | CS | t(12;12)(q13;q13) | SB505124 | druggable | ACVR1B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PHF12 | TMPRSS2 | t(17;21)(q11;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB3 | GRN | t(12;17)(q13;q21) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
IGF1R | ADPGK | t(15;15)(q26;q24) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
OS9 | ERBB3 | t(12;12)(q13;q13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
YPEL5 | NF1 | t(2;17)(p23;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
DOT1L | LSM7 | t(19;19)(p13;p13) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NRP1 | PTEN | t(10;10)(p11;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
WRB | ERG | t(21;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KRT6A | ERBB3 | t(12;12)(q13;q13) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
ADAMTS16 | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GUCA2A | TMPRSS2 | t(1;21)(p34;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PIK3CB | RASA2 | t(3;3)(q22;q23) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CEP85L | JAK2 | t(6;9)(q22;p24) | Pembrolizumab | druggable | JAK2 | alltypes | | | 29099951 |
ROCK2 | NCOA1 | t(2;2)(p25;p23) | AZD-5363 | druggable | ROCK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | DDX27 | t(5;20)(q33;q13) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GSK3B | TSC22D2 | t(3;3)(q13;q25) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
LYN | SHB | t(8;9)(q12;p13) | Dasatinib | druggable | LYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PLGRKT | JAK2 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,HNSC | CESC,HNSC | | 29099951 |
R3HDM4 | JAK3 | t(19;19)(p13;p13) | AZ-960 | druggable | JAK3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB2 | IKZF3 | t(17;17)(q12;q21) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | HNSC | CESC,HNSC | | 29099951 |
RPS6KA3 | PISD | t(X;22)(p22;q12) | LJI308 | druggable | RPS6KA3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PCNP | ATR | t(3;3)(q12;q23) | Berzosertib;Ceralasertib;VE-821 | druggable | ATR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AKT3 | PTPRR | t(1;12)(q44;q15) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | SKCM | SKCM,UVM | | 29099951 |
CD74 | IQCE | t(5;7)(q33;p22) | Crizotinib | druggable | CD74 | alltypes | LGG | | 29099951 |
NFYA | AKT2 | t(6;19)(p21;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ATR | R3HDM2 | t(3;12)(q23;q13) | Berzosertib;Ceralasertib;VE-821 | druggable | ATR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PARP1 | MDK | t(1;11)(q42;p11) | Niraparib;Olaparib;Talazoparib | druggable | PARP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AKT1 | ZNF461 | t(14;19)(q32;q13) | Afuresertib;AT-13148;AZD-5363;Ipatasertib;MK-2206;Uprosertib;AZD5363 | druggable | AKT1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
HRASLS2 | SMARCB1 | t(11;22)(q12;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RTN4RL1 | BRD1 | t(17;22)(p13;q13) | OF-1 | druggable | BRD1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
JAK2 | PKNOX2 | t(9;11)(p24;q24) | Pembrolizumab | druggable | JAK2 | alltypes | | | 29099951 |
NF1 | SPACA3 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
LYST | EGFR | t(1;7)(q42;p11) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
USP7 | ACTG1 | t(16;17)(p13;q25) | P22077 | druggable | USP7 | HNSC | CESC,HNSC | | 29099951 |
EGFR | TEAD2 | t(7;19)(p11;q13) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | HNSC | CESC,HNSC | | 29099951 |
CD74 | MYH9 | t(5;22)(q33;q12) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RAPGEFL1 | CDK12 | t(17;17)(q21;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
LBH | FLT4 | t(2;5)(p23;q35) | Cediranib | druggable | FLT4 | SKCM | SKCM,UVM | | 29099951 |
NRAS | CLDN14 | t(1;21)(p13;q22) | Cetuximab;Panitumumab | druggable | NRAS | STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CDK6 | ANKIB1 | t(7;7)(q21;q21) | Palbociclib | druggable | CDK6 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FRK | BEND3 | t(6;6)(q22;q21) | Dasatinib | druggable | FRK | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PTEN | RNLS | t(10;10)(q23;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | BLCA,KIRC,KIRP | | 29099951 |
EZH2 | NF1 | t(7;17)(q36;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | MPNST | | 29099951 |
CDK12 | PLXDC1 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
BGN | ERBB3 | t(X;12)(q28;q13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ZBTB17 | MTOR | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ALK | GALNT14 | t(2;2)(p23;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PPM1B | ZHX2 | t(2;8)(p21;q24) | Sorafenib | druggable | ZHX2 | SKCM | SKCM | | 29099951 |
EIF4G2 | ERBB3 | t(11;12)(p15;q13) | Sapitinib | druggable | ERBB3 | LGG | LGG | | 29099951 |
SIPA1L1 | NF1 | t(14;17)(q24;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB3 | PKM | t(12;15)(q13;q23) | Sapitinib | druggable | ERBB3 | LGG | LGG | | 29099951 |
LELP1 | ZHX2 | t(1;8)(q21;q24) | Sorafenib | druggable | ZHX2 | HNSC | CESC,HNSC | | 29099951 |
TERT | SLC7A2 | t(5;8)(p15;p22) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SNW1 | SMARCB1 | t(14;22)(q24;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
NOL10 | ROCK2 | t(2;2)(p25;p25) | AZD-5363 | druggable | ROCK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
HDAC1 | VTI1A | t(1;10)(p35;q25) | Entinostat;PCI-34051 | druggable | HDAC1 | SKCM | SKCM | | 29099951 |
COL3A1 | ERBB3 | t(2;12)(q32;q13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ITCH | SRC | t(20;20)(q11;q11) | Dasatinib | druggable | SRC | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TMPRSS2 | MRPS6 | t(21;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB3 | SUOX | t(12;12)(q13;q13) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
NRG1 | CDK1 | t(8;10)(p12;q21) | Dinaciclib | druggable | CDK1 | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
IGF1R | C15orf41 | t(15;15)(q26;q14) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RPL30 | ERBB3 | t(8;12)(q22;q13) | Sapitinib | druggable | ERBB3 | SKCM | SKCM,UVM | | 29099951 |
DSTYK | BRAF | t(1;7)(q32;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 29099951 |
C1QA | CD74 | t(1;5)(p36;q33) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ATP1B1 | NRG1 | t(1;8)(q24;p12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TMEFF2 | TMPRSS2 | t(2;21)(q32;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RAF1 | C9orf153 | t(3;9)(p25;q21) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ABL1 | FCHSD2 | t(9;11)(q34;q13) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,SKCM | SKCM | | 29099951 |
FGFR2 | CCDC186 | t(10;10)(q26;q25) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
WEE1 | CHRNA3 | t(11;15)(p15;q25) | Adavosertib;MK-1775 | druggable | WEE1 | HNSC | CESC,HNSC | | 29099951 |
USP47 | RRAS2 | t(11;11)(p15;p15) | P22077 | druggable | USP47 | SKCM | SKCM,UVM | | 29099951 |
BRD9 | STARD3 | t(5;17)(p15;q12) | I-BRD9 | druggable | BRD9 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SMARCA2 | USP7 | t(9;16)(p24;p13) | PFI-3;P22077 | druggable | SMARCA2;USP7 | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
HSP90AA1 | MOK | t(14;14)(q32;q32) | Luminespib | druggable | HSP90AA1 | HNSC | CESC,HNSC | | 29099951 |
GRB7 | ERBB2 | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
PIK3CB | ESYT3 | t(3;3)(q22;q22) | AZD-8186;Buparlisib | druggable | PIK3CB | HNSC | CESC,HNSC | | 29099951 |
DNPEP | TNKS | t(2;8)(q35;p23) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS | HNSC | CESC,HNSC | | 29099951 |
CD74 | ACP2 | t(5;11)(q33;p11) | Crizotinib | druggable | CD74 | alltypes | CESC,HNSC | | 29099951 |
GSK3B | PLA1A | t(3;3)(q13;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PEX1 | CDK6 | t(7;7)(q21;q21) | Palbociclib | druggable | CDK6 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TNKS2 | ATRN | t(10;20)(q23;p13) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS2 | HNSC | CESC,HNSC | | 29099951 |
CSN2 | BRD4 | t(4;19)(q13;p13) | Docetaxel;BET inhibitors;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | CESC,HNSC | CESC,HNSC | | 29099951 |
ERBB2 | NEUROD2 | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | HNSC | CESC,HNSC | | 29099951 |
TP53 | KIAA0753 | t(17;17)(p13;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CASC3 | CDK12 | t(17;17)(q21;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AKT3 | ZEB2 | t(1;2)(q44;q22) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | SKCM | SKCM,UVM | | 29099951 |
USP33 | CDK12 | t(1;17)(p31;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | MPNST | | 29099951 |
BCR | PPIL2 | t(22;22)(q11;q11) | Nilotinib | druggable | BCR | alltypes | BLCA,KIRC,KIRP | | 29099951 |
CD74 | UTRN | t(5;6)(q33;q24) | Crizotinib | druggable | CD74 | alltypes | LGG | | 29099951 |
ICE1 | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERG | SON | t(21;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NOTCH1 | MAPK1 | t(9;22)(q34;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | HNSC | CESC,HNSC | | 29099951 |
PARP1 | SPON2 | t(1;4)(q42;p16) | Niraparib;Olaparib;Talazoparib | druggable | PARP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PRKCA | NF1 | t(17;17)(q24;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
TGFBR1 | COL15A1 | t(9;9)(q22;q22) | SB505124 | druggable | TGFBR1 | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERCC2 | NOVA2 | t(19;19)(q13;q13) | Cisplatin | druggable | ERCC2 | BLCA | BLCA,KIRC,KIRP | | 29099951 |
NF1 | MAP2K4 | t(17;17)(q11;p12) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NDUFS4 | TMPRSS2 | t(5;21)(q11;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BRCA1 | ZNF675 | t(17;19)(q21;p12) | Niraparib;Olaparib;Rucaparib | druggable | BRCA1 | OV | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SLC25A42 | SMARCA4 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | SKCM | SKCM,UVM | | 29099951 |
CD74 | GCN1 | t(5;12)(q33;q24) | Crizotinib | druggable | CD74 | alltypes | DLBC | | 29099951 |
AKT2 | YIF1B | t(19;19)(q13;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CDK12 | FAM20A | t(17;17)(q12;q24) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SARS | TMPRSS2 | t(1;21)(p13;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TAF8 | ERG | t(6;21)(p21;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ALK | STK39 | t(2;2)(p23;q24) | Ceritinib;Crizotinib;PF2341066 | druggable | ALK | alltypes,SKCM | SKCM,UVM | | 29099951 |
CDKN2A | MYH10 | t(9;17)(p21;p13) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | | | 29099951 |
ERBB3 | P4HB | t(12;17)(q13;q25) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KIT | DNAJB14 | t(4;4)(q12;q23) | Cediranib;Dasatinib;Sorafenib | druggable | KIT | HNSC | CESC,HNSC | | 29099951 |
RNF216 | SMARCA4 | t(7;19)(p22;p13) | PFI-3 | druggable | SMARCA4 | SKCM | SKCM | | 29099951 |
TMLHE | CDK12 | t(X;17)(q28;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
LNPEP | FLT4 | t(5;5)(q15;q35) | Cediranib | druggable | FLT4 | SKCM | SKCM,UVM | | 29099951 |
PTEN | PYGB | t(10;20)(q23;p11) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | LGG | | 29099951 |
CHEK2 | C22orf31 | t(22;22)(q12;q12) | AZD-7762;MK-8776 | druggable | CHEK2 | HNSC | CESC,HNSC | | 29099951 |
SMARCA4 | SLC44A2 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
SYNE1 | ESR1 | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ELK3 | AKT2 | t(12;19)(q23;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | SKCM | SKCM,UVM | | 29099951 |
ERBB3 | DYNC1H1 | t(12;14)(q13;q32) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
SUZ12 | NF1 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RAF1 | GXYLT2 | t(3;3)(p25;p13) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MLLT3 | TMPRSS2 | t(9;21)(p21;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ABL1 | FUBP3 | t(9;9)(q34;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
LDLR | SMARCA4 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FAM134B | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ACVR1B | SUPT16H | t(12;14)(q13;q11) | SB505124 | druggable | ACVR1B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FASTKD3 | CDKN2A | t(5;9)(p15;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | MESO | | 29099951 |
PIK3CB | HHLA2 | t(3;3)(q22;q13) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
IGF1R | TRIP4 | t(15;15)(q26;q22) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
OSCP1 | NF1 | t(1;17)(p34;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | MESO | | 29099951 |
MYH11 | BCR | t(16;22)(p13;q11) | Nilotinib | druggable | BCR | alltypes | CESC,HNSC | | 29099951 |
ZBTB7A | MAP2K2 | t(19;19)(p13;p13) | PD-0325901;Trametinib | druggable | MAP2K2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | ACADVL | t(5;17)(q33;p13) | Crizotinib | druggable | CD74 | alltypes | CESC,HNSC | | 29099951 |
GSK3B | ATP11B | t(3;3)(q13;q26) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NCOA1 | ALK | t(2;2)(p23;p23) | Ceritinib;Crizotinib;PF2341066 | druggable | ALK | alltypes,SKCM | SKCM,UVM | | 29099951 |
LCK | CAMTA2 | t(1;17)(p35;p13) | Dasatinib | druggable | LCK | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ZBTB5 | SMARCA2 | t(9;9)(p13;p24) | PFI-3 | druggable | SMARCA2 | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
GUCA2A | ERG | t(1;21)(p34;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PLS1 | PIK3CB | t(3;3)(q23;q22) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PCNX3 | ERBB3 | t(11;12)(q13;q13) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
SH3BP4 | MST1R | t(2;3)(q37;p21) | Foretinib | druggable | MST1R | HNSC | CESC,HNSC | | 29099951 |
TP53 | ECSIT | t(17;19)(p13;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
AGAP1 | ERBB4 | t(2;2)(q37;q34) | Afatinib;Lapatinib | druggable | ERBB4 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BCR | HIC2 | t(22;22)(q11;q11) | Nilotinib | druggable | BCR | alltypes | SKCM | | 29099951 |
CD74 | CD40 | t(5;20)(q33;q13) | Crizotinib | druggable | CD74 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
EIF2AK3 | NBAS | t(2;2)(p11;p24) | GSK2606414 | druggable | EIF2AK3 | SKCM | SKCM,UVM | | 29099951 |
LYN | VPS13B | t(8;8)(q12;q22) | Dasatinib | druggable | LYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ALG14 | JAK1 | t(1;1)(p21;p31) | Pembrolizumab;Ruxolitinib | druggable | JAK1 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
ERBB2 | PSMB3 | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RPS6KA3 | BMX | t(X;X)(p22;p22) | LJI308 | druggable | RPS6KA3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NSRP1 | CDK12 | t(17;17)(q11;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | CXCR5 | t(5;11)(q33;q23) | Crizotinib | druggable | CD74 | alltypes | DLBC | | 29099951 |
CDK2 | UBE3A | t(12;15)(q13;q11) | Dinaciclib;MK-8776 | druggable | CDK2 | SKCM | SKCM,UVM | | 29099951 |
FAM129B | ERBB3 | t(9;12)(q34;q13) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NF1 | ADAP2 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CDK12 | TAF15 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
ANKS1A | AKT1 | t(6;14)(p21;q32) | Afuresertib;AT-13148;AZD-5363;Ipatasertib;MK-2206;Uprosertib | druggable | AKT1 | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
EGFR | GRB10 | t(7;7)(p11;p12) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
MYO18A | NF1 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MAPK1 | PRODH | t(22;22)(q11;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ZCCHC7 | TEK | t(9;9)(p13;p21) | Foretinib | druggable | TEK | BLCA,KIRC | BLCA,KIRC,KIRP | | 29099951 |
INPP4B | TMPRSS2 | t(4;21)(q31;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KIT | HOPX | t(4;4)(q12;q12) | Cediranib;Dasatinib;Sorafenib | druggable | KIT | LGG | LGG | | 29099951 |
TRIM33 | BCAR3 | t(1;1)(p13;p22) | Cabozantinib | druggable | TRIM33 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PTEN | BTRC | t(10;10)(q23;q24) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,HNSC | | 29099951 |
KIF26B | AKT3 | t(1;1)(q44;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | HNSC | CESC,HNSC | | 29099951 |
MDK | ERBB3 | t(11;12)(p11;q13) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
GRAP2 | BRD1 | t(22;22)(q13;q13) | OF-1 | druggable | BRD1 | SKCM | SKCM,UVM | | 29099951 |
SPECC1L | SMARCB1 | t(22;22)(q11;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB3 | RPN2 | t(12;20)(q13;q11) | Sapitinib | druggable | ERBB3 | HNSC | CESC,HNSC | | 29099951 |
HDAC8 | PHKA1 | t(X;X)(q13;q13) | PCI-34051 | druggable | HDAC8 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ESR1 | PDE7B | t(6;6)(q25;q23) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TERT | CCDC47 | t(5;17)(p15;q23) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
BRAF | TMPRSS2 | t(7;21)(q34;q22) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib;DNA-PKc inhibitors | druggable | BRAF;TMPRSS2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
HDAC1 | EIF3I | t(1;1)(p35;p35) | Entinostat;PCI-34051 | druggable | HDAC1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MTOR | MAD2L2 | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | SKCM | | 29099951 |
TMPRSS2 | MORC3 | t(21;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
VPS18 | NTRK3 | t(15;15)(q15;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB3 | COX4I2 | t(12;20)(q13;q11) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
NRG1 | GPRC5A | t(8;12)(p12;p13) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
IGF1R | RAB27A | t(15;15)(q26;q21) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
DLG5 | RET | t(10;10)(q22;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
DOT1L | PLEKHF1 | t(19;19)(p13;q12) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ABL1 | PRDM12 | t(9;9)(q34;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
FGFR2 | KLK2 | t(10;19)(q26;q13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,SKCM | SKCM,UVM | | 29099951 |
BRD9 | CBFB | t(5;16)(p15;q22) | I-BRD9 | druggable | BRD9 | HNSC | CESC,HNSC | | 29099951 |
RPS6KA1 | RASGRP3 | t(1;2)(p36;p22) | LJI308 | druggable | RPS6KA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
HSP90AA1 | MYH9 | t(14;22)(q32;q12) | Luminespib | druggable | HSP90AA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GRB7 | CDK12 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PIK3CB | GRM7 | t(3;3)(q22;p26) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
KIF1B | NF1 | t(1;17)(p36;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | BLCA,KIRC,KIRP | | 29099951 |
ROCK2 | ASAP2 | t(2;2)(p25;p25) | AZD-5363 | druggable | ROCK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CD74 | THSD4 | t(5;15)(q33;q23) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
GSK3B | SEMA5B | t(3;3)(q13;q21) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
THAP3 | LCK | t(1;1)(p36;p35) | Dasatinib | druggable | LCK | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ERBB2 | CLDN7 | t(17;17)(q12;p13) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CREM | FUS | t(10;16)(p11;p11) | Eribulin | druggable | FUS | SARC | SARC | | 28939748 |
SEPTIN7 | BRAF | t(7;7)(p14;q34) | PLX8394;Cobimetinib | druggable | BRAF | alltypes,SARC | SARC | | 28877062 |
NF1 | ASIC2 | t(17;17)(q11;q12) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718;29099951 |
FAM134C | BRCA1 | t(17;17)(q21;q21) | Niraparib;Olaparib;Rucaparib | druggable | BRCA1 | OV | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
DNAJC1 | BRCA1 | t(10;17)(p12;q21) | Niraparib;Olaparib;Rucaparib | druggable | BRCA1 | OV | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
ACPP | PIK3CB | t(3;3)(q22;q22) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
BCAP29 | BRAF | t(7;7)(q22;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
GLIS3 | NF1 | t(9;17)(p24;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
KAT6A | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
TP53 | CELSR1 | t(17;22)(p13;q13) | MIRA-1 | druggable | TP53 | HNSC,KIRC,LIHC,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | | 28783718 |
GOSR1 | NF1 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
PTEN | SGMS1 | t(10;10)(q11;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
TAOK1 | NF1 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 28783718;29099951 |
TP53 | NKIRAS2 | t(17;17)(p13;q21) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
PLCD3 | NF1 | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
NF1 | BCAS3 | t(17;17)(q11;q23) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | BLCA,KIRC,KIRP | | 28783718 |
NBPF1 | IGF1R | t(1;15)(p36;q26) | BMS-536924;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | STAD | GIST,STAD | | 28783718 |
BBS9 | BRAF | t(7;7)(p14;q34) | PLX8394 | druggable | BRAF | alltypes | | | 28783718 |
KDM6B | TP53 | t(17;17)(p13;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
NRF1 | NF1 | t(7;17)(q32;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
UBN2 | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
PHRF1 | AKT1 | t(11;14)(p15;q32) | Afuresertib;AT-13148;AZD-5363;Ipatasertib;MK-2206;Uprosertib;AZD5363 | druggable | AKT1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
TP53 | IGFL2 | t(17;19)(p13;q13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
TSPAN18 | NF1 | t(11;17)(p11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
PRAMEF2 | PTEN | t(1;10)(p36;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
NF1 | RNF135 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,HNSC,TGCT | | 28783718;29099951 |
RBM39 | SMARCB1 | t(20;22)(q11;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | SKCM | | 28783718 |
ACLY | NF1 | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | SKCM | | 28783718 |
PTEN | CRTC3 | t(10;15)(q23;q26) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
EZH2 | ZNF425 | t(7;7)(q36;q36) | GSK343 | druggable | EZH2 | SKCM | SKCM | | 28783718 |
SLC12A7 | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718;29099951 |
FRMD4A | PTEN | t(10;10)(p13;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
TP53 | SMYD4 | t(17;17)(p13;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
NF1 | CCR7 | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
ALK | CCDC61 | t(2;19)(p23;q13) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
ATM | ARFGAP3 | t(11;22)(q22;q13) | Olaparib | druggable | ATM | alltypes | HNSC | | 28783718 |
RUNX1 | ERG | t(21;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
NUBPL | NF1 | t(14;17)(q12;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | SARC | | 28783718 |
TP53 | MYBBP1A | t(17;17)(p13;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
CDC16 | TP53 | t(13;17)(q34;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28783718 |
DIAPH1 | PDGFRB | t(5;5)(q31;q32) | Imatinib | druggable | PDGFRB | MPD | MPD | | 28751768 |
ALK | LMO7 | t(2;13)(p23;q22) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28741662 |
NR2F1 | PTEN | t(5;10)(q15;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | MB | | 28726821 |
THAP9 | PTEN | t(4;10)(q21;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | MB | | 28726821 |
KMT2A | CLTC | t(11;17)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 28701730 |
BRAF | TOM1L2 | t(7;17)(q34;p11) | PLX8394;Cobimetinib | druggable | BRAF | alltypes,SARC | SARC | | 28692601 |
MBNL1 | ABL1 | t(3;9)(q25;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 28671688 |
ABL1 | SLC9A3R1 | t(9;17)(q34;q25) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 28671688 |
EDF1 | NOTCH1 | t(9;9)(q34;q34) | Gamma secretase inhibitors | druggable | NOTCH1 | ALL | ALL | | 28671688 |
CD99 | JAK2 | t(X;9)(p22;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 28671688 |
GAB1 | ABL1 | t(4;9)(q31;q34) | Nilotinib | druggable | ABL1 | alltypes | | | 28639284 |
KANK1 | NTRK3 | t(9;15)(p24;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | SKCM | | 28595733 |
IGH | BCL2A1 | t(14;15)(q32;q25) | ABT-737;Sabutoclax | druggable | BCL2A1 | DLBC | DLBC | | 28595732 |
SEPTIN14 | KMT2A | t(7;11)(p11;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 28573893 |
CREB3L3 | EWSR1 | t(19;22)(p13;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 28569045;30136738 |
DLG1 | BRAF | t(3;7)(q29;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28512242 |
RET | RRBP1 | t(10;20)(q11;p12) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28512242 |
TBL1XR1 | PDGFRB | t(3;5)(q26;q32) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | LAML | LAML | | 28509585 |
EML4 | NTRK3 | t(2;15)(p21;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib;Midostaurin;Pazopanib | druggable | NTRK3;EML4 | alltypes,GBM,SARC | CESC,COADREAD,GBM,IMT,LUAD,OV,PAAD,PRAD,SARC,STAD | | 28507274;28512242;28877062;29617662;29915264;30175468 |
CCDC186 | RET | t(10;10)(q11;q25) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28507274 |
RET | UEVLD | t(10;11)(q11;p15) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28507274 |
OSBPL9 | BRAF | t(1;7)(p32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28507274 |
ALK | HNRNPA1 | t(2;12)(p23;q13) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 28504207 |
SETD2 | NF1 | t(3;17)(p21;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | SARC | | 28498454 |
ALK | TIMP3 | t(2;22)(p23;q12) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 28490045 |
IGFBP5 | ALK | t(2;2)(p23;q35) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 28490045 |
ALK | THBS1 | t(2;15)(p23;q14) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 28490045 |
NUP153 | ABL1 | t(6;9)(p22;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 28408464 |
KIF13B | NRG1 | t(8;8)(p12;p12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28391773 |
RET | PPFIBP2 | t(10;11)(q11;p15) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28351223 |
SQSTM1 | NTRK3 | t(5;15)(q35;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28351223;28507274 |
AFAP1L2 | RET | t(10;10)(q11;q25) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28351223 |
FNDC3B | RARA | t(3;17)(q26;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 28314734 |
TMEM106B | BRAF | t(7;7)(p21;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 28299358 |
NF1 | RAB11FIP4 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | MPNST | | 28162975 |
BRAF | RUNDC1 | t(7;17)(q34;q21) | PLX8394 | druggable | BRAF | alltypes | MPNST | | 28162975 |
MLLT10 | MAP2K2 | t(10;19)(p12;p13) | PD-0325901;Trametinib | druggable | MAP2K2 | LAML | LAML | | 28112737 |
TFG | NTRK3 | t(3;15)(q12;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib;Midostaurin;Pazopanib | druggable | NTRK3 | alltypes,SARC | SARC | | 28097808 |
ERBB2 | JUP | t(17;17)(q12;q21) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 28052061 |
STAT5B | RARA | del(17)(q21q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 27911132 |
CRLF2 | IGHM | t(X;14)(p22;q32) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 27903646 |
EXTL2 | PTEN | t(1;10)(p21;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | ALL | | 27903646 |
JAK2 | TERF2 | t(9;16)(p24;q22) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27894077 |
ABL1 | ZMIZ1 | t(9;10)(q34;q22) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 27894077;28408464 |
ALK | EEF1G | t(2;11)(p23;q12) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | | 27840423 |
JAK2 | ATF7IP | t(9;12)(p24;p13) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051 |
RFX3 | JAK2 | t(9;9)(p24;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051;28408464 |
JAK2 | ZNF430 | t(9;19)(p24;p12) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051 |
JAK2 | USP25 | t(9;21)(p24;q21) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051;28408464 |
ABL1 | LSM14A | t(9;19)(q34;q13) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 27824051;28408464 |
CENPC | ABL1 | t(4;9)(q13;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 27824051;28408464 |
HOOK3 | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | ALL | | 27824051 |
JAK2 | ZNF274 | t(9;19)(p24;q13) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051;28408464 |
HMBOX1 | JAK2 | t(8;9)(p21;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051 |
SMU1 | JAK2 | t(9;9)(p21;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27824051 |
CLIP2 | MET | t(7;7)(q11.23;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET;CLIP2 | alltypes,LGG | LGG | | 27748748 |
SQSTM1 | RET | t(5;10)(q35;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27683183 |
MYO5A | NTRK3 | t(15;15)(q21;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | SKCM | | 27477320;28433076 |
NTRK3 | MYH9 | t(15;22)(q25;q12) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | SKCM | | 27477320 |
FN1 | ALK | inv(2)(p23q35) | Ceritinib;Crizotinib | druggable | ALK | alltypes | | | 27469327 |
ABL1 | PRRC2B | t(9;9)(q34;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 27428428 |
IGK | CDKN2A | t(2;9)(p11;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 27428428 |
EBF1 | JAK2 | t(5;9)(q33;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27428428 |
CD74 | PDGFRB | t(5;5)(q32;q33) | Crizotinib | druggable | CD74 | alltypes | ALL | | 27428428 |
PRRC2B | BCR | t(9;22)(q34;q11) | Dasatinib;Nilotinib;Ponatinib;Ruxolitinib | druggable | BCR | ALL,alltypes | ALL | | 27428428 |
JAK2 | SNX29 | t(9;16)(p24;p13) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 27428428;27824051 |
CD74 | HBA1 | t(5;16)(q33;p13) | Crizotinib | druggable | CD74 | alltypes | ALL | | 27428428 |
TPD52L1 | ROS1 | t(6;6)(q22;q22) | Crizotinib | druggable | ROS1 | alltypes,HNSC | CESC,HNSC | | 27237027 |
HOOK1 | ALK | t(1;2)(p32;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27225638 |
CSF2RA | CRLF2 | t(X;X)(p22;p22) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 27176795 |
ABL1 | SNX1 | t(9;15)(q34;q22) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 27176795 |
TGFB1 | HNRNPUL1 | t(19;19)(q13;q13) | LY2109761 | druggable | TGFB1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27165744 |
EXOSC10 | MTOR | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27165744 |
TP63 | NTRK2 | t(3;9)(q28;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes | CESC,HNSC | | 27158780 |
EGFR | PURB | t(7;7)(p11;p13) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27102076 |
EGFR | RAD51 | t(7;15)(p11;q15) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 27102076 |
LYN | ETV6 | t(8;12)(q12;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 27058227;29153093 |
PPP1R21 | ALK | t(2;2)(p16;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
MAPRE3 | ALK | t(2;2)(p23;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
CENPF | ALK | t(1;2)(q41;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
ALK | PRKAR1B | t(2;7)(p23;p22) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
WDCP | ALK | t(2;2)(p23;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
CAD | ALK | t(2;2)(p23;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26933125 |
IGF1R | TTC23 | t(15;15)(q26;q26) | BMS-536924;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | BLCA,KIRC | BLCA,KIRC,KIRP | | 26898937 |
BAIAP2L1 | BRAF | t(7;7)(q22;q34) | PLX8394 | druggable | BRAF | alltypes | | | 26892443 |
EML4 | BRAF | t(2;7)(p21;q34) | PLX8394 | druggable | BRAF | alltypes | | | 26892443 |
RPS6KA2 | NFIB | t(6;9)(q27;p22) | LJI308 | druggable | RPS6KA2 | OV | OV | | 26862087 |
OGDH | FGFR2 | t(7;10)(p13;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,HNSC,KIRC,LIHC,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | | 26680454 |
CAD | ALK | inv(2)(p23p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26633560 |
ANLN | ETV6 | t(7;12)(p14;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 26584717 |
LMNA | NTRK1 | t(1;1)(q22;q23) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib;Pazopanib | druggable | NTRK1 | alltypes,COADREAD,LUAD,SARC | CESC,COADREAD,IMT,KICH,LUAD,MB,OV,PAAD,PRAD,SARC,STAD | | 26563356;26716414;26863915;27259011;28097808;29915264;30134855;30276917 |
ELK4 | ERG | t(1;21)(q32;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26544944 |
LPXN | ETV6 | t(11;12)(q12;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 26542893 |
JAK3 | INSL3 | t(19;19)(p13;p13) | AZ-960 | druggable | JAK3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26536169 |
TNKS | RHOT1 | t(8;17)(p23;q11) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26536169 |
OFD1 | JAK2 | t(X;9)(p22;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 26404892;27176795 |
FGFR3 | WHSC1 | t(4;4)(p16;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26373574 |
FGFR1 | NTM | t(8;11)(p11;q25) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 26373574 |
FGFR3 | JAKMIP1 | t(4;4)(p16;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074;FGFR inhibitors | druggable | FGFR3 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 26373574 |
FGFR2 | NOL4 | t(10;18)(q26;q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26373574 |
NCALD | FGFR2 | t(8;10)(q22;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26373574 |
NPM1 | FGFR2 | t(5;10)(q35;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Ceritinib;Crizotinib | druggable | FGFR2;NPM1 | alltypes,COADREAD,HNSC,KIRC,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC,NSCLC | CESC,COADREAD,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,OV,PAAD,PRAD,STAD,UCEC | | 26373574 |
FGFR3 | TNIP2 | t(4;4)(p16;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074;FGFR inhibitors | druggable | FGFR3 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 26373574 |
FGFR2 | PLPP4 | t(10;10)(q26;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26373574 |
FGFR2 | CCDC7 | t(10;10)(p11;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26373574 |
PDGFRB | CPSF6 | t(5;12)(q32;q15) | Imatinib | druggable | PDGFRB | MPD | MPD | | 26355392 |
GOLGB1 | PDGFRB | t(3;5)(q13;q32) | Imatinib | druggable | PDGFRB | MPD | MPD | | 26355392 |
PDGFRB | MPRIP | t(5;17)(q32;p11) | Imatinib | druggable | PDGFRB | MPD | MPD | | 26355392 |
FOXP1 | PDGFRA | t(3;4)(p13;q12) | Imatinib | druggable | PDGFRA | HES | HES | | 26319757 |
BRAF | NUP214 | t(7;9)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
MYRIP | BRAF | t(3;7)(p22;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
NUB1 | BRAF | t(7;7)(q34;q36) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
BRAF | STK35 | t(7;20)(q34;p13) | PLX8394 | druggable | BRAF | alltypes | MESO | | 26314551 |
SLC12A7 | BRAF | t(5;7)(p15;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
ARMC10 | BRAF | t(7;7)(q22;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 26314551;27864876 |
BTF3L4 | BRAF | t(1;7)(p32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
AGAP3 | BRAF | t(7;7)(q34;q36) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 26314551;28512242 |
KLHL7 | BRAF | t(7;7)(p15;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
BRAF | CCDC91 | t(7;12)(q34;p11) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
ZNF767P | BRAF | t(7;7)(q34;q36) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
RBMS3 | BRAF | t(3;7)(p24;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
BRAF | CCDC6 | t(7;10)(q34;q21) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,GBM | GBM | | 26314551 |
CUX1 | BRAF | t(7;7)(q22;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SARC,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SARC,SKCM,STAD,UVM | | 26314551;28877062;29099951 |
BRAF | ETFA | t(7;15)(q34;q24) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
ZKSCAN1 | BRAF | t(7;7)(q22;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
GHR | BRAF | t(5;7)(p13;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
TANK | BRAF | t(2;7)(q24;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
RAD18 | BRAF | t(3;7)(p25;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
EPS15 | BRAF | t(1;7)(p32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26314551 |
BRAF | MZT1 | t(7;13)(q34;q21) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
DYNC1I2 | BRAF | t(2;7)(q31;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 26314551 |
GTF2I | BRAF | t(7;7)(q11;q34) | PLX8394;Dabrafenib;PLX-4720;Sorafenib;MEK inhibitors;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,LGG,SKCM | LGG,SKCM,UVM | | 26314551;28448514 |
GFPT1 | ALK | t(2;2)(p13;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26295973 |
VTCN1 | NRG1 | t(1;8)(p12;p12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26227178 |
FNDC11 | PTK6 | t(20;20)(q13;q13) | Dasatinib | druggable | PTK6 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26227178 |
MSL1 | CDK12 | t(17;17)(q12;q21) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26227178 |
CREB3L2 | EWSR1 | t(7;22)(q33;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 26212576;28939748 |
NRG1 | VAMP2 | t(8;17)(p12;p13) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26134228 |
FYN | TRAF3IP2 | t(6;6)(q21;q21) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26017449;29099951 |
BIRC6 | ALK | t(2;2)(p22;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26001147 |
JAK2 | SPAG9 | t(9;17)(p24;q21) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 25951811 |
STK3 | ETV6 | t(8;12)(q22;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 25933678 |
NOS2 | ERBB2 | t(17;17)(q11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25889497 |
ZNF207 | ERBB2 | t(17;17)(q11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25889497 |
MDK | ERBB2 | t(11;17)(p11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25889497 |
FGFR3 | IGH | dup(1)(q?) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 25812994 |
CCDC88A | ALK | del(2)(p16p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes,LGG | LGG | | 25795305 |
ALK | KTN1 | t(2;14)(p23;q22) | Ceritinib;Crizotinib | druggable | ALK | alltypes,LGG | LGG | | 25795305 |
SKIL | TMPRSS2 | t(3;21)(q26;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25749039 |
BCAM | AKT2 | t(19;19)(q13;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25733895 |
KMT2A | KRAS | t(11;12)(q23;p12) | Cobimetinib;Binimetinib;Trametinib | druggable | KRAS | ALL,alltypes | ALL | | 25730765 |
BICD2 | JAK2 | t(9;9)(p24;q22) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 25730765 |
FGFR2 | PPHLN1 | t(10;12)(q26;q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25608663 |
IRF2BP2 | RARA | t(1;17)(q42;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 25583766;27193600 |
RET | MYH13 | t(10;17)(q11;p13) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25546157 |
SQSTM1 | FGFR1 | t(5;8)(q35;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | LAML | | 25501022 |
SWAP70 | WEE1 | t(11;11)(p15;p15) | Adavosertib;MK-1775 | druggable | WEE1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
STAG2 | XIAP | t(X;X)(q25;q25) | AZD5582;LCL-161 | druggable | XIAP | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ATP2B4 | NFASC | t(1;1)(q32;q32) | Entrectinib;Larotrectinib | druggable | NFASC | GBM | GBM,LGG | | 25500544;29099951 |
PPP3CA | BRD2 | t(4;6)(q24;p21) | Birabresib;I-BET-762 | druggable | BRD2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AHI1 | CHEK2 | t(6;22)(q23;q12) | AZD-7762;MK-8776 | druggable | CHEK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDS5B | NF1 | t(13;17)(q13;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ATR | DBR1 | t(3;3)(q22;q23) | Berzosertib;Ceralasertib;VE-821 | druggable | ATR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TRMT61B | NF1 | t(2;17)(p23;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | LGG | | 25500544 |
BRAF | CIITA | t(7;16)(q34;p13) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDK12 | SMG6 | t(17;17)(p13;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDCD6 | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TPRG1 | FGFR3 | t(3;4)(q28;p16) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,HNSC | CESC,HNSC | | 25500544 |
NFASC | LRRN2 | t(1;1)(q32;q32) | Entrectinib;Larotrectinib | druggable | NFASC | GBM | GBM,LGG | | 25500544 |
MAPK1 | TOP3B | t(22;22)(q11;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
DDI2 | MTOR | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CLOCK | PDGFRA | t(4;4)(q12;q12) | Dasatinib;Imatinib | druggable | PDGFRA | STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDK6 | HEPACAM2 | t(7;7)(q21;q21) | Palbociclib | druggable | CDK6 | BLCA,KIRC | BLCA,KIRC,KIRP | | 25500544 |
KIT | UGT2B7 | t(4;4)(q12;q13) | Cediranib;Dasatinib;Sorafenib;Imatinib | druggable | KIT | SKCM | SKCM,UVM | | 25500544 |
FRK | DTNBP1 | t(6;6)(p22;q22) | Dasatinib | druggable | FRK | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RARA | CDK12 | t(17;17)(q12;q21) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MRVI1 | BCR | t(11;22)(p15;q11) | Nilotinib | druggable | BCR | alltypes,PAAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ABL1 | KYAT1 | t(9;9)(q34;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,HNSC | CESC,HNSC | | 25500544 |
ESR1 | ASPH | t(6;8)(q25;q12) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TERT | SLC2A13 | t(5;12)(p15;q12) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
EPS15L1 | BRD4 | t(19;19)(p13;p13) | Docetaxel;Apabetalone;Birabresib;I-BET-762 | druggable | BRD4 | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HDAC1 | PEPD | t(1;19)(p35;q13) | Entinostat;PCI-34051 | druggable | HDAC1 | BLCA,KIRC | BLCA,KIRC,KIRP | | 25500544 |
FGFR2 | USP10 | t(10;16)(q26;q24) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MET | WNT2 | t(7;7)(q31;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MST1R | FNDC3B | t(3;3)(p21;q26) | Foretinib | druggable | MST1R | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CABIN1 | SMARCB1 | t(22;22)(q11;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GSK3B | MAATS1 | t(3;3)(q13;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
SMARCA2 | DMRT1 | t(9;9)(p24;p24) | PFI-3 | druggable | SMARCA2 | HNSC | CESC,HNSC | | 25500544 |
MYRFL | MDM2 | t(12;12)(q15;q15) | Nutlin-3a (-) | druggable | MDM2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;29099951 |
FYN | LAMA4 | t(6;6)(q21;q21) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PIK3CB | KCNAB1 | t(3;3)(q22;q25) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MBOAT1 | FYN | t(6;6)(p22;q21) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NF1 | ANKFN1 | t(17;17)(q11;q22) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;26926675 |
ROCK2 | DTNB | t(2;2)(p23;p25) | AZD-5363 | druggable | ROCK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
USP1 | SGIP1 | t(1;1)(p31;p31) | ML323 | druggable | USP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
VAV3 | ZHX2 | t(1;8)(p13;q24) | Sorafenib | druggable | ZHX2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
LYN | MCM5 | t(8;22)(q12;q12) | Dasatinib | druggable | LYN | LUAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
JAK1 | HSD11B1 | t(1;1)(p31;q32) | Pembrolizumab;Ruxolitinib | druggable | JAK1 | alltypes,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RNH1 | HRAS | t(11;11)(p15;p15) | Tipifarnib | druggable | HRAS | HNSC | CESC,HNSC | | 25500544 |
AKAP13 | IGF1R | t(15;15)(q25;q26) | BMS-536924;BMS-754807;GSK1904529A;Linsitinib;NVP-ADW742 | druggable | IGF1R | COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544;28783718 |
AKT3 | PPP2R2A | t(1;8)(q44;p21) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MCL1 | CTSS | t(1;1)(q21;q21) | MIM1;Obatoclax Mesylate;Sabutoclax;UMI-77 | druggable | MCL1 | COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ARFGEF2 | TMPRSS2 | t(20;21)(q13;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NEDD4L | BCL2 | t(18;18)(q21;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ERG | ZNRF3 | t(21;22)(q22;q12) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
UAP1 | MDM2 | t(1;12)(q23;q15) | Nutlin-3a (-) | druggable | MDM2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PKM | USP7 | t(15;16)(q23;p13) | P22077 | druggable | USP7 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
SARAF | TNKS | t(8;8)(p12;p23) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
C2orf61 | ALK | t(2;2)(p21;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
WWTR1 | ATR | t(3;3)(q23;q25) | Berzosertib;Ceralasertib;VE-821 | druggable | ATR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RNF40 | PLK1 | t(16;16)(p11;p12) | MK-1775 | druggable | PLK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
EGFR | MDM2 | t(7;12)(p11;q15) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib;Nutlin-3a (-) | druggable | EGFR;MDM2 | GBM,LGG | GBM,LGG | | 25500544 |
PCM1 | NRG1 | t(8;8)(p12;p22) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BRD1 | MAPK12 | t(22;22)(q13;q13) | OF-1 | druggable | BRD1 | GBM,LGG | GBM,LGG | | 25500544 |
CDK6 | STXBP6 | t(7;14)(q21;q12) | Palbociclib | druggable | CDK6 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
EZH2 | AUTS2 | t(7;7)(q11;q36) | GSK343 | druggable | EZH2 | HNSC | CESC,HNSC | | 25500544 |
BRAF | HIBADH | t(7;7)(p15;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 25500544 |
CUX1 | MAP2K1 | t(7;15)(q22;q22) | PD-0325901;Trametinib;Cobimetinib | druggable | MAP2K1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ERBB3 | FOXA1 | t(12;14)(q13;q21) | Sapitinib | druggable | ERBB3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ESR1 | BNC2 | t(6;9)(q25;p22) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDE4B | JAK1 | t(1;1)(p31;p31) | Pembrolizumab;Ruxolitinib | druggable | JAK1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HDAC1 | SERINC2 | t(1;1)(p35;p35) | Entinostat;PCI-34051 | druggable | HDAC1 | GBM,LGG | GBM,LGG | | 25500544 |
ABL1 | DDX27 | t(9;20)(q34;q13) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 25500544 |
FGFR1 | SLC20A2 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
DOCK8 | JAK2 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 25500544;29099951 |
NRG1 | AKAP13 | t(8;15)(p12;q25) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TNS2 | ACVR1B | t(12;12)(q13;q13) | SB505124 | druggable | ACVR1B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RAF1 | TMEM40 | t(3;3)(p25;p25) | Cobimetinib;MEK inhibitors;Sorafenib | druggable | RAF1 | ALL,PRAD | ALL,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;27824051 |
LRRK2 | GXYLT1 | t(12;12)(q12;q12) | GSK2578215A | druggable | LRRK2 | LGG | LGG | | 25500544 |
FGGY | RPS6KA1 | t(1;1)(p32;p36) | LJI308 | druggable | RPS6KA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NUAK2 | LEMD1 | t(1;1)(q32;q32) | WZ4003 | druggable | NUAK2 | HNSC | CESC,HNSC | | 25500544 |
PIK3CB | PCCB | t(3;3)(q22;q22) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TRIM24 | NTRK2 | t(7;9)(q34;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RET | ANK3 | t(10;10)(q11;q21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TP53 | RBBP8 | t(17;18)(p13;q11) | MIRA-1 | druggable | TP53 | BLCA,KIRC | BLCA,KIRC,KIRP | | 25500544 |
MRE11A | YAP1 | t(11;11)(q21;q22) | Mirin | druggable | MRE11A | LGG | LGG | | 25500544 |
GSK3B | LSAMP | t(3;3)(q13;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
DROSHA | TERT | t(5;5)(p13;p15) | BIBR-1532 | druggable | TERT | SKCM | SKCM,UVM | | 25500544 |
ERBB2 | SLC39A11 | t(17;17)(q12;q25) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
JAK2 | CDK12 | t(9;17)(p24;q12) | Pembrolizumab;AZ-960;Ruxolitinib;Cemiplimab;Nivolumab | druggable | JAK2;CDK12 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NF1 | CACNA1G | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AKT3 | GCSAML | t(1;1)(q44;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | GBM,LGG | GBM,LGG | | 25500544 |
EXOC6 | CHEK1 | t(10;11)(q23;q24) | Adavosertib;AZD-7762;MK-8776 | druggable | CHEK1 | COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BCR | MOV10L1 | t(22;22)(q11;q13) | Nilotinib | druggable | BCR | alltypes,PAAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
SLC29A3 | ERBB2 | t(10;17)(q22;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ARID2 | TMPRSS2 | t(12;21)(q12;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PZP | TOP1 | t(12;20)(p13;q12) | Camptothecin;Irinotecan | druggable | TOP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RPS6KA2 | MCHR2 | t(6;6)(q16;q27) | LJI308 | druggable | RPS6KA2 | LGG | LGG | | 25500544 |
KANSL1L | ERBB4 | t(2;2)(q34;q34) | Afatinib;Lapatinib | druggable | ERBB4 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;29099951 |
TTC13 | JAK2 | t(1;9)(q42;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BRD1 | APOL5 | t(22;22)(q12;q13) | OF-1 | druggable | BRD1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
C1orf226 | PTEN | t(1;10)(q23;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ANK3 | CDK1 | t(10;10)(q21;q21) | Dinaciclib | druggable | CDK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BRAF | SLC26A4 | t(7;7)(q22;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,HNSC | CESC,HNSC | | 25500544 |
CDK12 | AKAP1 | t(17;17)(q12;q22) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CTDSP2 | MDM2 | t(12;12)(q14;q15) | Nutlin-3a (-) | druggable | MDM2 | GBM,LGG | GBM,LGG | | 25500544 |
MAPK1 | KCNJ4 | t(22;22)(q11;q13) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDGFRB | FAR1 | t(5;11)(q32;p15) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
KIT | RCOR1 | t(4;14)(q12;q32) | Cediranib;Dasatinib;Sorafenib;Imatinib;Regorafenib;Sunitinib | druggable | KIT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TRIM33 | COL24A1 | t(1;1)(p13;p22) | Cabozantinib | druggable | TRIM33 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
KRAS | LMNTD1 | t(12;12)(p12;p12) | Binimetinib;Cobimetinib;Trametinib;Cetuximab;Panitumumab;Regorafenib | druggable | KRAS | alltypes,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ESR1 | TFB1M | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | HNSC | CESC,HNSC | | 25500544 |
WHSC1L1 | FGFR1 | t(8;8)(p11;p12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ABL1 | EXOSC2 | t(9;9)(q34;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,HNSC | CESC,HNSC | | 25500544 |
SMARCA4 | DOCK6 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NRG1 | RAB3IL1 | t(8;11)(p12;q12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ZNF586 | SRC | t(19;20)(q13;q11) | Dasatinib | druggable | SRC | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ESR1 | USP25 | t(6;21)(q25;q21) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TNKS | ASAH1 | t(8;8)(p22;p23) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
FARP2 | TP53 | t(2;17)(q37;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MTOR | CR1L | t(1;1)(p36;q32) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | LGG | | 25500544 |
TGFB1 | CCDC97 | t(19;19)(q13;q13) | LY2109761 | druggable | TGFB1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TMEM135 | CHEK1 | t(11;11)(q14;q24) | Adavosertib;AZD-7762;MK-8776 | druggable | CHEK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ATF7IP | TMPRSS2 | t(12;21)(p13;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HIVEP3 | DOT1L | t(1;19)(p34;p13) | EPZ004777;Pinometostat | druggable | DOT1L | SKCM | SKCM,UVM | | 25500544 |
MET | DYNC1I1 | t(7;7)(q21;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
OCEL1 | SMARCA4 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
DOT1L | ONECUT3 | t(19;19)(p13;p13) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GSK3B | FSTL1 | t(3;3)(q13;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NTRK2 | PAN3 | t(9;13)(q21;q12) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes | CESC,HNSC | | 25500544 |
RPS6KA1 | LIN28A | t(1;1)(p36;p36) | LJI308 | druggable | RPS6KA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
FYN | PTPRZ1 | t(6;7)(q21;q31) | Crizotinib;Foretinib | druggable | PTPRZ1 | LGG | LGG | | 25500544 |
PIK3CB | TSPO | t(3;22)(q22;q13) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
JAK2 | CSTF3 | t(9;11)(p24;p13) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NF1 | PSMD11 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | ALL,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;28671687 |
KDM4C | JAK2 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ROCK2 | NTSR2 | t(2;2)(p25;p25) | AZD-5363 | druggable | ROCK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NLK | NF1 | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ZNF587 | SRC | t(19;20)(q13;q11) | Dasatinib | druggable | SRC | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
USP1 | EFCAB7 | t(1;1)(p31;p31) | ML323 | druggable | USP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BCR | TOM1 | t(22;22)(q11;q12) | Nilotinib | druggable | BCR | alltypes | CESC,HNSC | | 25500544 |
KDM6A | ANOS1 | t(X;X)(p11;p22) | Tazemetostat | druggable | KDM6A | BLCA | BLCA,KIRC,KIRP | | 25500544 |
BAZ2A | ACVR1B | t(12;12)(q13;q13) | SB505124 | druggable | ACVR1B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
LYN | NTRK3 | t(8;15)(q12;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | CESC,HNSC | | 25500544 |
ATP2B4 | ERBB4 | t(1;2)(q32;q34) | Afatinib;Lapatinib | druggable | ERBB4 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RFX3 | SMARCA2 | t(9;9)(p24;p24) | PFI-3 | druggable | SMARCA2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDKAL1 | HSP90AA1 | t(6;14)(p22;q32) | Luminespib | druggable | HSP90AA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ATR | ADGRV1 | t(3;5)(q23;q14) | Berzosertib;Ceralasertib;VE-821 | druggable | ATR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ALK | KCNQ5 | t(2;6)(p23;q13) | Ceritinib;Crizotinib;PF2341066 | druggable | ALK | alltypes,SKCM | SKCM,UVM | | 25500544 |
C17orf64 | TOP1 | t(17;20)(q23;q12) | Camptothecin;Irinotecan | druggable | TOP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
KIF5B | HPS4 | t(10;22)(p11;q12) | Cabozantinib | druggable | KIF5B | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GRHL2 | TMPRSS2 | t(8;21)(q22;q22) | DNA-PKc inhibitors | druggable | TMPRSS2 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDK6 | BICD1 | t(7;12)(q21;p11) | Palbociclib | druggable | CDK6 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RARA | STAT3 | t(17;17)(q21;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | CESC,COADREAD,LAML,LUAD,OV,PAAD,PRAD,STAD | | 25500544;29237593 |
STK3 | ZHX2 | t(8;8)(q22;q24) | Sorafenib | druggable | ZHX2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HIVEP1 | MAPK1 | t(6;22)(p24;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
FRS2 | MDM2 | t(12;12)(q15;q15) | Nutlin-3a (-) | druggable | MDM2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BCL2A1 | EPB41L1 | t(15;20)(q25;q11) | ABT-737;Sabutoclax | druggable | BCL2A1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GSK3A | ZNF564 | t(19;19)(p13;q13) | SB216763 | druggable | GSK3A | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ESR1 | MTHFD1L | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TULP4 | ESR1 | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | HNSC | CESC,HNSC | | 25500544 |
ECHDC1 | FYN | t(6;6)(q21;q22) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HDAC1 | KPNA6 | t(1;1)(p35;p35) | Entinostat;PCI-34051 | druggable | HDAC1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CAMKK1 | MAP2K2 | t(17;19)(p13;p13) | PD-0325901;Trametinib | druggable | MAP2K2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
FGFR1 | ADAM18 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MCOLN2 | CDK1 | t(1;10)(p22;q21) | Dinaciclib | druggable | CDK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDC42SE1 | TNKS | t(1;8)(q21;p23) | AZ6102;MN-64;WIKI4;XAV-939 | druggable | TNKS | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TOP1 | CDH4 | t(20;20)(q12;q13) | Camptothecin;Irinotecan | druggable | TOP1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GSK3B | COL8A1 | t(3;3)(q12;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
WEE1 | HEATR6 | t(11;17)(p15;q23) | Adavosertib;MK-1775 | druggable | WEE1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ATRX | BCL2 | t(X;18)(q21;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | LGG | LGG | | 25500544 |
BRD9 | CEP72 | t(5;5)(p15;p15) | I-BRD9 | druggable | BRD9 | HNSC | CESC,HNSC | | 25500544 |
EPB41L2 | DOT1L | t(6;19)(q23;p13) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
FYN | KMT2A | t(6;11)(q21;q23) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PABPN1 | BCL2L2 | t(14;14)(q11;q11) | ABT-737;Navitoclax;Obatoclax Mesylate | druggable | BCL2L2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDK2 | CDK12 | t(17;17)(q12;q21) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NARS2 | ERBB2 | t(11;17)(q14;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ABCB5 | NF1 | t(7;17)(p21;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
JAK2 | SIK2 | t(9;11)(p24;q23) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NF1 | CLTC | t(17;17)(q11;q23) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
C7orf73 | BRAF | t(7;7)(q33;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AKAP13 | NTRK3 | t(15;15)(q25;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes,LGG | LGG | | 25500544 |
PGS1 | BIRC5 | t(17;17)(q25;q25) | YM155 (Sepantronium Bromide) | druggable | BIRC5 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AKT3 | ACVR2A | t(1;2)(q44;q22) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MTMR12 | TERT | t(5;5)(p13;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ERG | KCNJ6 | t(21;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RPS6KA2 | PSMG4 | t(6;6)(p25;q27) | LJI308 | druggable | RPS6KA2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
EGFR | DYM | t(7;18)(p11;q21) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | HNSC | CESC,HNSC | | 25500544 |
BRD1 | MLC1 | t(22;22)(q13;q13) | OF-1 | druggable | BRD1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AKT2 | UPF1 | t(19;19)(p13;q13) | Afuresertib;AZD-5363;MK-2206;Uprosertib | druggable | AKT2 | LGG | LGG | | 25500544 |
HHAT | KIF5B | t(1;10)(q32;p11) | Cabozantinib | druggable | KIF5B | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PTEN | CTNNA3 | t(10;10)(q21;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PHC2 | HSP90AA1 | t(1;14)(p35;q32) | Luminespib | druggable | HSP90AA1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BRAF | SUGCT | t(7;7)(p14;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ST7 | MET | t(7;7)(q31;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,LGG | LGG | | 25500544 |
TUBD1 | CDK12 | t(17;17)(q12;q23) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
BSDC1 | HDAC1 | t(1;1)(p35;p35) | Entinostat;PCI-34051 | druggable | HDAC1 | HNSC | CESC,HNSC | | 25500544 |
BRD2 | CALR | t(6;19)(p21;p13) | Birabresib;I-BET-762 | druggable | BRD2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CDKN2A | MGA | t(9;15)(p21;q15) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | BLCA,KIRC,KIRP | | 25500544 |
KRAS | RERGL | t(12;12)(p12;p12) | Binimetinib;Cobimetinib;Trametinib;Cetuximab;Panitumumab;Regorafenib | druggable | KRAS | alltypes,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ESR1 | ARMT1 | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MTHFS | BCL2A1 | t(15;15)(q25;q25) | ABT-737;Sabutoclax | druggable | BCL2A1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
HDAC1 | LRRC42 | t(1;1)(p32;p35) | Entinostat;PCI-34051 | druggable | HDAC1 | LGG | LGG | | 25500544 |
ABL1 | ADAMTSL2 | t(9;9)(q34;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
SMARCA4 | ICAM1 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
CMTM8 | RAF1 | t(3;3)(p22;p25) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NRG1 | SDC4 | t(8;20)(p12;q12) | Lapatinib | druggable | NRG1 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
MDM2 | NUP107 | t(12;12)(q15;q15) | Nutlin-3a (-) | druggable | MDM2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RAF1 | XPC | t(3;3)(p25;p25) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TGFB1 | FXYD5 | t(19;19)(q13;q13) | LY2109761 | druggable | TGFB1 | BLCA,KIRC | BLCA,KIRC,KIRP | | 25500544 |
SBF2 | MDM2 | t(11;12)(p15;q15) | Nutlin-3a (-) | druggable | MDM2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TTLL7 | TERT | t(1;5)(p31;p15) | BIBR-1532 | druggable | TERT | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ACADM | EGFR | t(1;7)(p31;p11) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | HNSC | CESC,HNSC | | 25500544 |
NUAK2 | CYB5R1 | t(1;1)(q32;q32) | WZ4003 | druggable | NUAK2 | LGG | LGG | | 25500544 |
PAK1 | ERG | t(11;21)(q14;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
LAP3 | NTRK2 | t(4;9)(p15;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 25500544 |
TP53 | GID4 | t(17;17)(p11;p13) | MIRA-1 | druggable | TP53 | LGG | LGG | | 25500544 |
JARID2 | ATM | t(6;11)(p22;q22) | Olaparib | druggable | ATM | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AR | MCL1 | t(X;1)(q12;q21) | MIM1;Obatoclax Mesylate;Sabutoclax;UMI-77 | druggable | MCL1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ARHGEF7 | MAPK1 | t(13;22)(q34;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GSK3B | GPR156 | t(3;3)(q13;q13) | SB216763 | druggable | GSK3B | COADREAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
NTRK2 | RASEF | t(9;9)(q21;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PDSS2 | SMARCA4 | t(6;19)(q21;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TPMT | NF1 | t(6;17)(p22;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ERBB2 | CDK12 | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab;Cemiplimab;Nivolumab;Pembrolizumab | druggable | ERBB2;CDK12 | COADREAD,LUAD,OV,PAAD,PRAD,STAD,alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PIK3CB | COPB2 | t(3;3)(q22;q23) | AZD-8186;Buparlisib | druggable | PIK3CB | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
JAK2 | GLDC | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,HNSC | CESC,HNSC | | 25500544 |
NF1 | ACACA | t(17;17)(q11;q12) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GALNT11 | EZH2 | t(7;7)(q36;q36) | GSK343 | druggable | EZH2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AKT3 | RGS7 | t(1;1)(q43;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | GBM,LGG | GBM,LGG | | 25500544 |
BCR | UPB1 | t(22;22)(q11;q11) | Nilotinib | druggable | BCR | alltypes | CESC,HNSC | | 25500544 |
SRGAP2 | CDKN2A | t(1;9)(q32;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | CESC,HNSC | | 25500544 |
AURKA | PCK1 | t(20;20)(q13;q13) | Alisertib | druggable | AURKA | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
WHSC1L1 | NUTM1 | t(8;15)(p11;q14) | Docetaxel | druggable | NUTM1 | CESC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | | 25466466;25500544;29099951 |
ALK | MALAT1 | t(2;11)(p23;q13) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25417114 |
BRAF | CCNY | t(7;10)(q34;p11) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25417114;25500544 |
BRAF | ERC1 | t(7;12)(q34;p13) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25417114 |
VCL | FGFR2 | t(10;10)(q22;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25417114;25500544 |
SVOPL | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25417114;26314551 |
SOBP | MET | t(6;7)(q21;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25407104 |
LACE1 | MET | t(6;7)(q21;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25407104 |
CHTOP | NTRK1 | t(1;1)(q21.3;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1;CHTOP | alltypes,GBM | GBM | | 25384085 |
FN1 | FGFR1 | t(2;8)(q35;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | | | 25319834;27443518 |
ZFC3H1 | MDM2 | t(12;12)(q15;q21) | Milademetan Tosylate;RO5045337 | druggable | MDM2 | SARC | SARC | | 25300797 |
RUNX2 | MDM2 | t(6;12)(p21;q15) | Milademetan Tosylate;RO5045337 | druggable | MDM2 | SARC | SARC | | 25300797 |
MTOR | TP53BP1 | t(1;15)(p36;q15) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25238935 |
CREB3L2 | EWSR1 | t(7;22)(q34;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 25231134 |
FGFR3 | AES | t(4;19)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
TFG | MET | t(3;7)(q12;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET;TFG | alltypes,COADREAD,LGG,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LGG,LUAD,OV,PAAD,PRAD,SARC,STAD | | 25204415;25417114;25500544;27748748;28510278 |
FGFR1 | RHOT1 | t(8;17)(p11;q11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
FKBP15 | RET | t(9;10)(q32;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
RAF1 | AGGF1 | t(3;5)(p25;q13) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
CPD | ERBB2 | t(17;17)(q11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
FAM114A2 | BRAF | t(5;7)(q33;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
BCL2L11 | BRAF | t(2;7)(q13;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
RBPMS | NTRK3 | t(8;15)(p12;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
NTRK1 | SSBP2 | t(1;5)(q23;q14) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
MET | C8orf34 | t(7;8)(q31;q13) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;26536169;29099951 |
ZC3HAV1 | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544;26314551 |
ALK | GTF2IRD1 | t(2;7)(p23;q11) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
SQSTM1 | NTRK2 | t(5;9)(q35;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 25204415 |
MAP2K2 | INSR | t(19;19)(p13;p13) | PD-0325901;Trametinib | druggable | MAP2K2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
FGFR3 | ELAVL3 | t(4;19)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;PD-173074 | druggable | FGFR3 | alltypes,LGG | LGG | | 25204415;25500544 |
ATG7 | BRAF | t(3;7)(p25;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 25204415;25500544 |
FGFR1 | ZNF577 | t(8;19)(p11;q13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
TBL1XR1 | RET | t(3;10)(q26;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
RAF1 | PAPD7 | t(3;5)(p25;p15) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
PPP4R3B | ALK | t(2;2)(p16;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
TRIM24 | BRAF | t(7;7)(q33;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 25204415;26314551;29099951 |
RET | AKAP13 | t(10;15)(q11;q25) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
ANK1 | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
IRF2BP2 | NTRK1 | t(1;1)(q23;q42) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
BAIAP2L1 | MET | t(7;7)(q22;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
KIT | PDGFRA | t(4;4)(q12;q12) | Cediranib;Dasatinib;Sorafenib;Imatinib;Regorafenib;Sunitinib | druggable | KIT;PDGFRA | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
WHSC1L1 | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
NTRK1 | TRG | t(1;7)(q23;p14) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
FGFR2 | TACC2 | t(10;10)(q26;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;26373574;29099951 |
MET | OXR1 | t(7;8)(q31;q23) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
ALK | TPM1 | t(2;15)(p23;q22) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,BLCA,COADREAD,KIRC,LUAD,OV,PAAD,PRAD,STAD | BLCA,CESC,COADREAD,KIRC,KIRP,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
CASZ1 | MTOR | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
BRAF | AGK | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,GBM,LGG,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,GBM,LGG,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 25204415;25417114;25500544;26314551;27864876;29099951 |
MTSS1 | ERBB2 | t(8;17)(q24;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
NTRK1 | SQSTM1 | t(1;5)(q23;q35) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib;Pazopanib | druggable | NTRK1 | alltypes,COADREAD,LUAD,SARC | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SARC,STAD | | 25204415;25417114;25500544;28097808 |
AFAP1 | NTRK2 | t(4;9)(p16;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 25204415;25500544 |
FGFR1 | ZNF791 | t(8;19)(p11;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
KDM7A | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544;26314551 |
MET | KIF5B | t(7;10)(q31;p11) | Cabozantinib;Crizotinib;Foretinib;Savolitinib | druggable | KIF5B;MET | LUAD,alltypes,COADREAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25500544 |
KAZN | MTOR | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
TRIM24 | NTRK2 | t(7;9)(q33;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
RET | SPECC1L | t(10;22)(q11;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
AP3B1 | BRAF | t(5;7)(q14;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415;25417114;25500544 |
ACBD5 | RET | inv(10)(p12q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25175022 |
SMARCA4 | DNM2 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25136073;25500544 |
PTPRZ1 | MET | t(7;7)(q31;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET;PTPRZ1 | alltypes,GBM,LGG | GBM,LGG | | 25135958;25204415;27748748;30343896 |
NR4A3 | FUS | t(9;16)(q31;p11) | Eribulin | druggable | FUS | SARC | SARC | | 25130955 |
RCSD1 | ABL2 | inv(1)(q24q25) | Dasatinib | druggable | RCSD1 | ALL | ALL | | 25098428 |
RCSD1 | ABL2 | t(1;1)(q24;q25) | Dasatinib | druggable | RCSD1 | ALL | ALL | | 25098428;27824051;27855558;27894077;28408464 |
ROS1 | CLTC | t(6;17)(q22;q23) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25079552;25204415;25500544 |
FUS | NFATC2 | t(16;20)(p11;q13) | Eribulin | druggable | FUS | SARC | SARC | | 25010205 |
ALK | A2M | t(2;12)(p23;p13) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT,SARC | | 24965693;28705706 |
CSF2RA | CRLF2 | del(X)(p22p22) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 24935070 |
ROS1 | YWHAE | t(6;17)(q22;p13) | Crizotinib | druggable | ROS1 | alltypes,IMT | IMT | | 24875859 |
ALK | PRKAR1A | t(2;17)(p23;q24) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 24875859 |
TFG | ROS1 | t(3;6)(q12;q22) | Crizotinib;Foretinib | druggable | ROS1;TFG | alltypes,IMT,LGG | IMT,LGG | | 24875859;25723109;28449809 |
FN1 | ALK | t(2;2)(p23;q35) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 24875859;25682942;27469327;28490045 |
LMNA | ALK | t(1;2)(q22;p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT | | 24875859 |
TPR | ALK | t(1;2)(q31;p23) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24736082 |
NTRK2 | VCL | t(9;10)(q21;q22) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2;VCL | alltypes,GBM,LGG | GBM,LGG | | 24705251 |
AGBL4 | NTRK2 | t(1;9)(p33;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2;AGBL4 | alltypes,GBM,LGG | GBM,LGG | | 24705251 |
BTBD1 | NTRK3 | t(15;15)(q25;q25) | Entrectinib;Larotrectinib;Merestinib;Crizotinib | druggable | NTRK3;BTBD1 | alltypes,GBM,LGG | GBM,LGG | | 24705251 |
FAM76A | FGFR2 | t(1;10)(p35;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24563622 |
RABGAP1L | NTRK1 | t(1;1)(q23;q25) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24563076 |
FGFR2 | SHTN1 | t(10;10)(q25;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24563076;26373574;29099951 |
TACC3 | FGFR2 | t(4;10)(p16;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24550739;24563076 |
FGFR2 | MGEA5 | t(10;10)(q24;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24550739 |
DIP2B | ERBB2 | t(12;17)(q13;q12) | Afatinib;Lapatinib;Sapitinib | druggable | ERBB2 | BLCA,KIRC | BLCA,KIRC,KIRP | | 24476821 |
CD74 | NRG1 | t(5;8)(q33;p12) | Crizotinib;Lapatinib | druggable | CD74;NRG1 | alltypes,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24469108;24913807 |
LMNA | NTRK1 | del(1)(q22q23) | Entrectinib;Larotrectinib;Merestinib;pan-TRK inhibitor;Crizotinib | druggable | NTRK1 | alltypes,COADREAD,LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24445538;26563355 |
BRAF | CEP89 | t(7;19)(q34;q13) | PLX8394 | druggable | BRAF | alltypes | | | 24445538 |
ROS1 | PPFIBP1 | t(6;12)(q22;p11) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
PWWP2A | ROS1 | t(5;6)(q33;q22) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
ROS1 | ZCCHC8 | t(6;12)(q22;q24) | Crizotinib | druggable | ROS1 | alltypes,GBM | GBM | | 24445538;27121553 |
BRAF | LSM14A | t(7;19)(q34;q13) | PLX8394 | druggable | BRAF | alltypes | | | 24445538 |
ROS1 | ERC1 | t(6;12)(q22;p13) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
NTRK1 | TP53 | t(1;17)(q23;p13) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1 | alltypes | | | 24445538 |
ROS1 | SHTN1 | t(6;10)(q22;q25) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
ROS1 | MYO5A | t(6;15)(q22;q21) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
HLA-A | ROS1 | t(6;6)(p22;q22) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
ROS1 | CLIP1 | t(6;12)(q22;q24) | Crizotinib | druggable | ROS1 | alltypes | | | 24445538 |
LASP1 | CDK12 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24395524 |
BCAS4 | AURKA | t(20;20)(q13;q13) | Alisertib | druggable | AURKA | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24395524 |
TPM3 | JAK2 | t(1;9)(q21;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 24367274 |
CDKN2A | IFNWP19 | t(9;9)(p21;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 24367274 |
BRAF | MRPS33 | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,BLCA,KIRC | BLCA,KIRC,KIRP | | 24345920;25500544 |
PAPSS1 | BRAF | t(4;7)(q25;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 24345920 |
TAX1BP1 | BRAF | t(7;7)(p15;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 24345920;25204415;29099951 |
BRAF | CDC27 | t(7;17)(q34;q21) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM,UVM | | 24345920;25204415;29099951 |
EGFR | PSPHP1 | t(7;7)(p11;p11) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 24261984 |
NFASC | PRELP | t(1;1)(q32;q32) | Entrectinib;Larotrectinib | druggable | NFASC | GBM | GBM,LGG | | 24261984;25500544 |
EGFR | PPM1H | t(7;12)(p11;q14) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 24261984;25500544 |
NFASC | RTN3 | t(1;11)(q32;q13) | Entrectinib;Larotrectinib | druggable | NFASC | GBM | GBM,LGG | | 24261984 |
TERT | NAA30 | t(5;14)(p15;q22) | BIBR-1532 | druggable | TERT | GBM,LGG | GBM,LGG | | 24261984;25500544 |
MGAT1 | FLT4 | t(5;5)(q35;q35) | Cediranib | druggable | FLT4 | GBM,LGG | GBM,LGG | | 24261984 |
NFASC | SOX13 | t(1;1)(q32;q32) | Entrectinib;Larotrectinib | druggable | NFASC | GBM | GBM,LGG | | 24261984;25500544 |
CAPZA2 | MET | t(7;7)(q31;q31) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24240688;25500544;26536169;26689674;27158780 |
FGFR2 | CD44 | t(10;11)(q26;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24240688 |
MED1 | CDK12 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 24240688;25500544;29099951 |
ALK | TRAF1 | t(2;9)(p23;q33) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | | 23999969;25501114;26187744 |
NF1 | CDK5RAP3 | t(17;17)(q11;q21) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23972288;25500544 |
REV3L | FYN | t(6;6)(q21;q21) | Dasatinib | druggable | FYN | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD,UVM | | 23972288;25500544;25567983 |
NF1 | NLE1 | t(17;17)(q11;q12) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23972288;25500544 |
SEC61G | EGFR | t(7;7)(p11;p11) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401;24261984;29092923 |
EGFR | VOPP1 | t(7;7)(p11;p11) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401 |
CCDC127 | TERT | t(5;5)(p15;p15) | BIBR-1532 | druggable | TERT | GBM,LGG | GBM,LGG | | 23917401;25500544 |
LANCL2 | SEPTIN14 | t(7;7)(p11;p11) | Erlotinib;Lapatinib | druggable | SEPTIN14 | GBM | GBM,LGG | | 23917401;24261984 |
BCAN | NTRK1 | t(1;1)(q23;q23) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1;BCAN | alltypes,GBM,LGG | GBM,LGG | | 23917401;24261984 |
METTL21B | MAPK1 | t(12;22)(q14;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | GBM,LGG | GBM,LGG | | 23917401 |
CASK | EML4 | t(X;2)(p11;p21) | Entrectinib;Larotrectinib | druggable | EML4 | GBM | GBM,LGG | | 23917401;24261984 |
EGFR | ERP44 | t(7;9)(p11;q31) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401;25500544 |
NFASC | NTRK1 | t(1;1)(q23;q32) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK1;NFASC | alltypes,GBM,LGG | GBM,LGG | | 23917401;24261984;25204415;25500544 |
COBL | SEPTIN14 | t(7;7)(p11;p12) | Erlotinib;Lapatinib | druggable | SEPTIN14 | GBM | GBM,LGG | | 23917401;25500544 |
MDM2 | PPM1H | t(12;12)(q14;q15) | Nutlin-3a (-) | druggable | MDM2 | GBM,LGG | GBM,LGG | | 23917401;24261984 |
EGFR | PSPH | t(7;7)(p11;p11) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401;24261984 |
EGFR | CAND1 | t(7;12)(p11;q14) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401 |
C12orf49 | MDM2 | t(12;12)(q15;q24) | Nutlin-3a (-) | druggable | MDM2 | GBM,LGG | GBM,LGG | | 23917401;24261984 |
MTOR | CAMTA1 | t(1;1)(p36;p36) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | GBM,LGG | | 23917401;24261984 |
EGFR | SEPTIN14 | t(7;7)(p11;p11) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR;SEPTIN14 | GBM,LGG | GBM,LGG | | 23917401;24261984;25204415;25500544 |
EGFR | GNS | t(7;12)(p11;q14) | Erlotinib;Lapatinib;Afatinib;AZD-3759;Foretinib;Gefitinib;Osimertinib;Sapitinib | druggable | EGFR | GBM,LGG | GBM,LGG | | 23917401;25500544 |
MKRN1 | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,HNSC,KIRC,LGG,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | CESC,COADREAD,HNSC,KIRC,KIRP,LGG,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | | 23817572;25204415;25417114;25500544;26314551;26680454 |
RNF130 | BRAF | t(5;7)(q35;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 23817572 |
QKI | NTRK2 | t(6;9)(q26;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 23817572 |
GNAI1 | BRAF | t(7;7)(q21;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 23817572 |
NACC2 | NTRK2 | t(9;9)(q21;q34) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 23817572 |
CLCN6 | BRAF | t(1;7)(p36;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 23817572 |
FGD4 | LRRK2 | t(12;12)(p11;q12) | GSK2578215A | druggable | LRRK2 | GBM,LGG | GBM,LGG | | 23796897;25500544 |
RIC1 | JAK2 | t(9;9)(p24;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,HNSC,KIRC,LIHC,LUAD,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,UCEC | | 23716474 |
FAM133B | CDK6 | t(7;7)(q21;q21) | Palbociclib | druggable | CDK6 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | ALL,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23637631;25500544 |
PPARGC1A | EGFR | t(4;7)(p15;p11) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | HNSC | CESC,HNSC | | 23637631 |
ATG7 | RAF1 | t(3;3)(p25;p25) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23637631;27624885 |
ABL1 | CBFB | t(9;16)(q34;q22) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,GBM,LGG | GBM,LGG | | 23637631 |
CEP85L | ROS1 | t(6;6)(q22;q22) | Crizotinib | druggable | ROS1 | alltypes,GBM,LGG | GBM,LGG,SARC | | 23637631;24261984;25204415;25500544 |
PSMD3 | CDK12 | dup(17)(q12q21) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23636398 |
DOT1L | CSNK1G2 | dup(19)(p13p13) | EPZ004777;Pinometostat | druggable | DOT1L | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23636398 |
CDK12 | EIF4A3 | inv(17)(q12q25) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23636398 |
TSPAN11 | ERBB2 | t(12;17)(p11;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23636398 |
MTOR | CHD1 | t(1;5)(p36;q21) | Everolimus;Temsirolimus | druggable | MTOR | alltypes | LAML | | 23634996;25500544 |
NF1 | LRRC37B | t(17;17)(q11;q11) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | LAML | | 23634996 |
KMT2A | AP2A2 | t(11;11)(p15;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | ME2 | t(11;18)(q23;q21) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958;26556690 |
KMT2A | C2CD3 | t(11;11)(q13;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | VAV1 | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | ARHGEF12 | t(11;11)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 23628958;27428428 |
KMT2A | MYH11 | t(11;16)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958;25552680 |
KMT2A | AKAP13 | t(11;15)(q23;q25) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | DCPS | t(11;11)(q23;q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | BUD13 | t(11;11)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
KMT2A | NRIP3 | t(11;11)(p15;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23628958 |
NRF1 | BRAF | t(7;7)(q32;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23622249;27624885 |
CRKL | MAPK1 | t(22;22)(q11;q11) | SCH772984;Ulixertinib;VX-11e | druggable | MAPK1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23622249 |
FGFR3 | IGL | t(4;22)(p16;q11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | CLL | | 23584505 |
MACF1 | BRAF | t(1;7)(p34;q34) | PLX8394;Dabrafenib;PLX-4720;MEK inhibitors;Sorafenib;Cobimetinib;Trametinib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | druggable | BRAF | alltypes,COADREAD,LGG,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LGG,LUAD,OV,PAAD,PRAD,STAD | | 23583981;25204415;25417114;25500544 |
FAM131B | BRAF | t(7;7)(q34;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 23583981;23817572 |
NAV1 | NTRK2 | t(1;9)(q32;q21) | Entrectinib;Larotrectinib;Merestinib | druggable | NTRK2 | alltypes,LGG | LGG | | 23583981 |
FXR1 | BRAF | t(3;7)(q26;q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 23583981 |
FGFR2 | CASP7 | t(10;10)(q25;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23558953;25204415 |
ERLIN2 | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23558953;25204415 |
OFD1 | FGFR2 | t(X;10)(p22;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,HNSC,KIRC,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | CESC,COADREAD,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,OV,PAAD,PRAD,STAD,UCEC | | 23558953;25417114;25500544 |
AFF3 | FGFR2 | t(2;10)(q11;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23558953;28783718 |
SLC45A3 | FGFR2 | t(1;10)(q32;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23558953 |
BAG4 | FGFR1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,HNSC | CESC,HNSC | | 23558953;25204415;25500544 |
FGFR2 | CCDC6 | t(10;10)(q21;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23558953;25204415;25500544 |
CCAR2 | FGFR2 | t(8;10)(p21;q26) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,HNSC | CESC,HNSC | | 23558953;25204415;25500544 |
CDKN2A | MTAP | t(9;9)(p21;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23334668;25500544 |
PATJ | AGBL4 | t(1;1)(p31;p33) | Entrectinib | druggable | AGBL4 | LGG | LGG | | 23334667 |
RNF214 | KMT2A | t(11;11)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 23299548 |
NABP1 | RARA | t(2;17)(q32;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 23287866 |
ROS1 | KDELR2 | t(6;7)(q22;p22) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22980976 |
KRAS | CDH13 | t(12;16)(p12;q23) | Binimetinib;Cobimetinib;Trametinib;Cetuximab;Panitumumab;Regorafenib | druggable | KRAS | alltypes,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22975805 |
FGFR2 | CIT | t(10;12)(q26;q24) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547 | druggable | FGFR2 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22975805 |
PDGFRA | SCAF11 | t(4;12)(q12;q12) | Dasatinib;Imatinib | druggable | PDGFRA | STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22975805 |
ROS1 | CCDC6 | t(6;10)(q22;q21) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22975805 |
CHCHD3 | MET | t(7;7)(q31;q33) | Crizotinib;Foretinib;Savolitinib | druggable | MET | alltypes,HNSC | CESC,HNSC | | 22960745 |
USP24 | CDK1 | t(1;10)(p32;q21) | Dinaciclib | druggable | CDK1 | HNSC | CESC,HNSC | | 22960745 |
CDKN2A | FOCAD | t(9;9)(p21;p21) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 22960745;25500544;29099951 |
PIK3CB | BFSP2 | t(3;3)(q22;q22) | AZD-8186;Buparlisib | druggable | PIK3CB | HNSC | CESC,HNSC | | 22960745;25500544 |
ROCK2 | SH3YL1 | t(2;2)(p25;p25) | AZD-5363 | druggable | ROCK2 | HNSC | CESC,HNSC | | 22960745 |
EIF2AK3 | PRKD3 | t(2;2)(p11;p22) | GSK2606414 | druggable | EIF2AK3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22952423 |
EGFR | POLD1 | t(7;19)(p11;q13) | Afatinib;AZD-3759;Erlotinib;Foretinib;Gefitinib;Lapatinib;Osimertinib;Sapitinib | druggable | EGFR | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22952423 |
MPRIP | TP53 | t(17;17)(p11;p13) | MIRA-1 | druggable | TP53 | HNSC,KIRC,LIHC,LUAD,LUSC,UCEC | CESC,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,UCEC | | 22941188 |
JAK2 | STRN3 | t(9;14)(p24;q12) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 22897847 |
RANBP2 | ABL1 | t(2;9)(q13;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 22897847;28408464 |
NUP214 | ABL1 | t(9;9)(q34;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1;NUP214 | ALL,alltypes | ALL | | 22897847;24367274;27428428;27824051;28671687;28671688 |
PAX5 | JAK2 | t(9;9)(p13;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 22897847;27176795;27265895;27428428;27824051 |
CHEK2 | PARVB | inv(22)(q12q13) | AZD-7762;MK-8776 | druggable | CHEK2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22895193 |
FGFR1 | TACC1 | t(8;8)(p11;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074;Ponatinib | druggable | FGFR1;TACC1 | alltypes,GBM,LGG | GBM,LGG | | 22837387;23583981;24705250;29617662 |
MAGI3 | AKT3 | t(1;1)(p13;q44) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib | druggable | AKT3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22722202 |
TPR | FGFR1 | t(1;8)(q31;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 22619110;25037443 |
ANXA4 | ABL1 | t(2;9)(p13;q34) | Nilotinib;Dasatinib | druggable | ABL1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22553170 |
RPS6KA3 | PTPRF | t(X;1)(p22;p34) | LJI308 | druggable | RPS6KA3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22553170 |
RPS6KA3 | DDX53 | t(X;X)(p22;p22) | LJI308 | druggable | RPS6KA3 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22553170 |
RET | BCR | t(10;22)(q11;q11) | Nilotinib;Imatinib;TKIs;Bosutinib;Dasatinib;Ponatinib;Sorafenib | druggable | BCR;RET | alltypes,CML | CML | | 22513837 |
FGFR1OP | RET | t(6;10)(q27;q11) | Sorafenib | druggable | RET | CML | CML | | 22513837;24315414 |
ESR1 | CCDC170 | t(6;6)(q25;q25) | Brilanestrant;Fulvestrant;Tamoxifen | druggable | ESR1 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22496636;23972288;25500544 |
TRIM33 | POSTN | t(1;13)(p13;q13) | Cabozantinib | druggable | TRIM33 | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22496456 |
CD74 | MBD6 | t(5;12)(q33;q13) | Crizotinib | druggable | CD74 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22496456 |
UBA1 | CDK4 | t(X;12)(p11;q14) | Palbociclib | druggable | CDK4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22496456 |
ALK | PTPN3 | t(2;9)(p23;q31) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,LUSC,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,LUSC,OV,PAAD,PRAD,STAD | | 22334442 |
WDCP | ALK | dup(2)(p23p24) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22327622;24296758;24691006;25469238 |
KMT2A | ABI2 | t(2;11)(q33;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 22304832;23628958 |
SQSTM1 | NUP214 | t(5;9)(q31;q34) | Imatinib | druggable | NUP214 | ALL | ALL | | 22237106 |
KMT2A | PDS5A | t(4;11)(p14;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 22230297;23628958 |
SMARCA4 | CARM1 | t(19;19)(p13;p13) | PFI-3 | druggable | SMARCA4 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22101766;22496636;23119097 |
FBXL20 | CDK12 | t(17;17)(q12;q12) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22101766;22952423;25500544 |
SEC16A | NOTCH1 | t(9;9)(q34;q34) | Gamma secretase inhibitors | druggable | NOTCH1 | ALL,BRCA | ALL,BRCA,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22101766;22424054;25104330;25500544;26561834;27372070;28671687 |
SMARCB1 | MARK3 | t(14;22)(q32;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 22101766;22952423 |
KMT2A | TOP3A | t(11;17)(q23;p11) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 22050635;23628958 |
FGFR3 | IGH | del(13)(q14) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 22023516 |
IGH | FGFR3 | del(17)(p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 22023516 |
EWSR1 | CREB3L1 | t(11;22)(p11;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 21987447;23588368;24441665;24896634;25123073 |
NT5C2 | KMT2A | t(1;11;10)(p32;q23;q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 21900057 |
MEF2C | KMT2A | t(5;11)(q14;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 21900057 |
FOXO1 | FGFR1 | t(8;13;9)(p11;q14;q32) | AZD4547;BGJ398;Debio1347;Erdafitinib;Bortezomib | druggable | FGFR1;FOXO1 | alltypes,SARC | SARC | | 21666686 |
SMARCB1 | WASF2 | t(1;22)(p36;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | SARC | | 21625565 |
ERBB2 | PGAP3 | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,HNSC,LUAD,OV,PAAD,PRAD,STAD | | 21625565;29099951 |
INPP5D | ABL1 | t(2;9)(q37;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 21625237 |
TMEM104 | CDK12 | t(17;17)(q12;q25) | Cemiplimab;Nivolumab;Pembrolizumab | druggable | CDK12 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21622959;22101766;22952423 |
SEC22B | NOTCH2 | t(1;1)(p12;q21) | Gamma secretase inhibitors | druggable | NOTCH2 | BRCA | BRCA,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21622959;22101766;27372070 |
WIPF2 | ERBB2 | t(17;17)(q12;q21) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21622959;22101766 |
PML | ADAMTS17 | ins(15;17)(q22;q21q26) | ATRA + arsenic trioxide | druggable | PML | LAML | LAML | | 21529941 |
ADAMTS17 | RARA | ins(15;17)(q22;q21q26) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 21529941 |
FAM131B | BRAF | del(7)(q34q34) | PLX8394;Dabrafenib;PLX-4720 | druggable | BRAF | alltypes,LGG | LGG | | 21424530;25040262 |
CNTRL | KIT | t(4;9)(q12;q33) | Cediranib;Dasatinib;Sorafenib | druggable | KIT | LAML | LAML | | 21403647 |
SNX2 | ABL1 | t(5;9)(q23;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 21391972 |
FOXP1 | ABL1 | t(3;9)(p13;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 21391972;27894077 |
RALGPS1 | ABL1 | der(22)(?)t(9;22)(q34;q11)ins(22;9)(q11;q33q33) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 21338279 |
CUX1 | FGFR1 | t(7;8)(q22;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | ALL | | 21330321 |
SEC31A | JAK2 | t(4;9)(q21;p24) | Pembrolizumab;AZ-960;Ruxolitinib | druggable | JAK2 | alltypes,DLBC | DLBC,HL | | 21325169 |
ESR1 | CCDC170 | t(6;6)(q25.1;q25.1) | anti-estrogens;Brilanestrant;Fulvestrant;Tamoxifen;AZD9496 | druggable | ESR1 | BRCA,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BRCA,CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21272361;22496636;23972288;25099679;25500544;25923108;27489248 |
HDAC8 | CITED1 | t(X;X)(q13;q13) | PCI-34051 | druggable | HDAC8 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21261984 |
GOPC | ROS1 | t(6;6)(q22;q22) | Crizotinib | druggable | ROS1 | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | | 21253578;22661537;23052255;25231053 |
KMT2A | SUGP2 | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 21252984 |
EWSR1 | SMARCA5 | t(4;22)(q31;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 21113140 |
VCL | ALK | t(2;10)(p23;q22) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,SKCM,STAD | | 21076462;21213368;24698962;25413595;29329131 |
FKBP5 | ERG | t(6;21)(p21;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21036922 |
GMPR | ERG | t(6;21)(p22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 20964841 |
CIP2A | KMT2A | t(3;11)(q13;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 20943269;23628958 |
KMT2A | CT45A2 | ins(X;11)(q26;q23q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 20920256 |
SQSTM1 | NUP214 | t(5;9)(q35;q34) | Imatinib | druggable | NUP214 | ALL | ALL,LAML | | 20851865;22237106;27766616 |
NUP98 | KMT2A | inv(11)(p15q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 20558618 |
NUP98 | KMT2A | t(11;11)(p15;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 20558618 |
KMT2A | SACM1L | t(3;11)(p21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 20553989 |
FGFR3 | IGH | del(1)(p21) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 20537706 |
RANBP2 | ALK | inv(2)(p23q13) | Ceritinib;Crizotinib;PF2341066 | druggable | ALK | alltypes,LAML | LAML,MPD | | 20428197;24307515;24613277;25766836 |
PARP1 | MIXL1 | t(1;1)(q42;q42) | Niraparib;Olaparib;Talazoparib | druggable | PARP1 | SKCM | SKCM,UVM | | 20179022 |
KANK1 | PDGFRB | t(5;9)(q32;p24) | Imatinib | druggable | PDGFRB | MPD | MPD,NEC | | 20164854;21685469 |
PAX5 | JAK2 | del(9)(p13p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 20160164 |
CDC6 | RARA | ins(15;17)(q22;q21q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 20155840 |
PML | CDC6 | ins(15;17)(q22;q21q21) | ATRA + arsenic trioxide | druggable | PML | LAML | LAML | | 20155840 |
SLC45A3 | ERG | del(21)(q22q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 20118910 |
SLC45A3 | ERG | t(21;21)(q22;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 20118910 |
PDGFRB | BIN2 | t(5;12)(q32;q13) | Imatinib | druggable | PDGFRB | MPD | MPD | | 20085582 |
WDR48 | PDGFRB | t(1;3;5)(p36;p22;q32) | Imatinib | druggable | PDGFRB | MPD | MPD | | 20085582 |
GOLGA4 | PDGFRB | t(3;5)(p22;q32) | Cediranib;Dasatinib;Foretinib;Sorafenib;Imatinib | druggable | PDGFRB | DLBC,MPD | DLBC,MPD | | 20085582 |
RAF1 | DAZL | t(3;3)(p24;p25) | MEK inhibitors;Sorafenib | druggable | RAF1 | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 20033038;25418731 |
ETV6 | SETBP1 | t(12;18)(p13;q12) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | LAML,MPD | | 19965692 |
ETV1 | ERG | t(7;21)(p21.2;q22.3) | PARP inhibitors | druggable | ERG | PRAD | PRAD | | 19962179 |
PAX3 | NCOA2 | t(2;8)(q36;q13) | Bortezomib | druggable | PAX3 | SARC | SARC | | 19953635 |
CRLF2 | IGH | t(X;14)(p22;q34) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 19838194 |
KMT2A | CASP8AP2 | t(6;11)(q15;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 19837277;23628958 |
P2RY8 | CRLF2 | del(Y)(p11p11) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 19641190;19838194;20378752;22484421;23091296;23145900 |
P2RY8 | CRLF2 | del(X)(p22p22) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 19641190;19838194;20378752;22484421;23091296;23145900;27637012 |
IGH | CRLF2 | t(Y;14)(p11;q32) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 19641190;19838194 |
IGH | CRLF2 | t(X;14)(p22;q32) | mTOR inhibitors | druggable | CRLF2 | ALL | ALL | | 19641190 |
HERPUD1 | ERG | t(16;21)(q13;q22.3) | PARP inhibitors | druggable | ERG | PRAD | PRAD | | 19592507 |
SMG6 | ERG | t(17;21)(p13.1;q22.3) | PARP inhibitors | druggable | ERG | PRAD | PRAD | | 19592507 |
HERPUD1 | ERG | t(16;21)(q13;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 19592507 |
KMT2A | NRIP3 | inv(11)(p15q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 19454493 |
IGH | FGFR3 | del(13)(q?) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 19324902;25812994 |
KMT2A | VAV1 | ins(11;19)(q23;p13p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 19262598 |
KMT2A | C2CD3 | inv(11)(q13q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 19262598 |
KMT2A | LAMC3 | t(9;11)(q34;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 19262598;23628958 |
SET | NUP214 | del(9)(q34.11) | Imatinib | druggable | NUP214 | ALL | ALL | | 19166587 |
TRA | NOTCH1 | t(9;14)(q34;q11) | Gamma secretase inhibitors | druggable | NOTCH1 | ALL | ALL | | 19151773 |
PAX5 | JAK2 | inv(9)(p13p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL | | 19020546 |
MYO18A | PDGFRB | t(5;17)(q32;q11) | Imatinib | druggable | PDGFRB | MPD | HES,MPD | | 19006078;20107158 |
SLC45A3 | ERG | t(1;21)(q32;q22) | PARP inhibitors | druggable | ERG | PRAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 18794152;19649210;20118910 |
SLC45A3 | ERG | t(1;21)(q31.2;q22.3) | PARP inhibitors | druggable | ERG | PRAD | PRAD | | 18794152 |
TTC6 | ESR2 | del(14)(q21.1) | Brilanestrant | druggable | ESR2 | PRAD | PRAD | | 18794142 |
ETV1 | TP53 | t(7;17)(p21.3;p13.1) | MIRA-1 | druggable | TP53 | PRAD | PRAD | | 18794142 |
TP53 | ETV1 | t(7;17)(p21;p13) | MIRA-1 | druggable | TP53 | COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 18794142 |
AFF3 | BCL2 | t(2;18)(q11;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | | 18622426 |
SSBP2 | JAK2 | t(5;9)(q14;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes | ALL,LAML | | 18618714;27824051 |
IGH | FGFR3 | dup(8)(q24q24) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 18418408 |
ETV6 | NCOA2 | t(8;12)(q13;p13) | Midostaurin | druggable | ETV6 | LAML | ALL,LAML | | 18281529;22373549;24367274 |
NF1 | ASIC2 | del(17)(q11.2) | Cobimetinib;Trametinib | druggable | NF1 | alltypes | | | 18265407 |
SPTBN1 | PDGFRB | t(2;5)(p21;q33) | Imatinib | druggable | PDGFRB | MPD | MPD | | 18262053 |
SPTBN1 | PDGFRB | t(2;5)(p16;q32) | Imatinib | druggable | PDGFRB | MPD | MPD | | 18262053 |
SFPQ | ABL1 | t(1;9)(p34;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;AZD0530 | druggable | ABL1 | ALL,alltypes,LAML | ALL,LAML | | 18205209;21388681 |
CPSF6 | FGFR1 | t(8;12)(p11;q15) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 18205209 |
PRKG2 | PDGFRB | t(4;5)(q21.1;q31.3) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | KIRC | KICH,KIRC,KIRP | | 18166785 |
ZMIZ1 | ABL1 | t(9;10)(q34;q23) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 18007576 |
BRD3 | NUTM1 | t(9;15)(q34;q14) | Birabresib;I-BET-762;Docetaxel | druggable | BRD3;NUTM1 | HNSC,KIRC,LIHC,LUSC,UCEC,CESC | CESC,HNSC,KIRC,KIRP,LIHC,LUSC,UCEC | | 17934517 |
PAX5 | PML | t(9;15)(p13;q22) | ATRA + arsenic trioxide | druggable | PML | LAML | ALL,LAML | | 17897302 |
FGFR3 | IGH | del(1)(p21p21) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 17854306;18676019 |
CREB3L1 | FUS | t(11;16)(p11;q34) | Eribulin | druggable | FUS | SARC | SARC | | 17721195 |
PDGFRB | ERC1 | t(5;12)(q32;p13) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | LAML | LAML | | 17690697 |
ERC1 | PDGFRB | t(5;12)(q33;p13) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | LAML | LAML,NEC | | 17690697 |
EWSR1 | SP3 | t(2;22)(q31;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | NEC,SARC | | 17690209 |
SMARCB1 | ETV1 | t(7;22)(p21;q11) | Tazemetostat | druggable | SMARCB1 | alltypes | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 17671502 |
ALK | RANBP2 | inv(2)(p23) | Ceritinib;Crizotinib | druggable | ALK | alltypes | TGCT | | 17656252 |
FUS | FEV | t(2;16)(q35;p11) | Eribulin | druggable | FUS | SARC | SARC | | 17620387;22387997 |
ESR1 | NOTCH1 | t(6;9)(q22-23;p23-24) | anti-estrogens;Brilanestrant;Fulvestrant;Tamoxifen;AZD9496;Gamma secretase inhibitors | druggable | ESR1;NOTCH1 | BRCA | BRCA | | 17591932;17640550;18084325;19921709;22522925;22722201;22722202 |
STRN | PDGFRA | t(2;4)(p22;q12) | Imatinib;TKIs | druggable | PDGFRA | HES,MPD | HES,MPD | | 17555450 |
RCSD1 | ABL1 | t(1;9)(q24;q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;AZD0530 | druggable | ABL1;RCSD1 | ALL,alltypes,LAML | ALL,LAML | | 17541395;19794096;21863287 |
GOPC | ROS1 | del(6)(q22) | Crizotinib | druggable | ROS1 | alltypes,LGG | LGG | | 17361217 |
FCHSD1 | BRAF | t(5;7)(q31;q34) | PLX8394;Sorafenib;MEK inhibitors;Dabrafenib;PLX-4720;Binimetinib+Encorafenib;Cobimetinib;Cobimetinib+Vemurafenib;Dabrafenib+Trametinib;Trametinib;Vemurafenib | druggable | BRAF | alltypes,SKCM | SKCM | | 17301836 |
FIP1L1 | RARA | t(4;17)(q12;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | CLL,CML,LAML,NEC | | 17301809;18603554;21750086 |
CAPRIN1 | PDGFRB | ins(11;5)(p13;q15q32) | Imatinib | druggable | PDGFRB | MPD | HES,MPD | | 17296564;20107158 |
PDGFRB | CAPRIN1 | t(5;11)(q33;p13) | Imatinib | druggable | PDGFRB | MPD | MPD | | 17296564 |
GIT2 | PDGFRB | t(5;12)(q32;q24) | Imatinib | druggable | PDGFRB | MPD | HES,MPD | | 17296564;20107158 |
PDGFRB | GIT2 | t(5;12)(q33;q24) | Imatinib | druggable | PDGFRB | MPD | MPD | | 17296564 |
IGH | FGFR3 | der(8)(q24) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 17209057 |
CREB1 | EWSR1 | t(2;22)(q33;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 17000668;17724745;18094413;19561568;21997693;23252871;28009602 |
CREB1 | EWSR1 | t(2;22)(q34;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | NEC,SARC | | 17000668;17724745;18094413;18666823;19561568;21997693 |
FGFR3 | IGH | dup(1)(q21q21) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 16996589;17854306;20537706;20739955;21523726;21836613;22023516;22426624;22547600;22641455 |
CDK5RAP2 | PDGFRA | ins(9;4)(q33;q12q25) | Imatinib | druggable | PDGFRA | HES | HES | | 16845659;20107158 |
KMT2A | SORBS2 | t(4;11)(q35;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | | 16628191 |
KMT2A | DCPS | del(11)(q23q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 16511515 |
KIF5B | PDGFRA | t(4;10)(q12;p11) | Imatinib;TKIs | druggable | PDGFRA | HES,MPD | HES,MPD | | 16498388;20107158 |
CCDC94 | KMT2A | t(9;11;19)(p21;q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 16450356 |
EXOC4 | PTEN | t(7;10)(q33;q23) | AZD8186;GSK2636771 | druggable | PTEN | alltypes | | | 15834588 |
PCM1 | JAK2 | t(8;9)(p22;p24) | Ruxolitinib;Pembrolizumab | druggable | JAK2 | ALL,alltypes,HES | ALL,CML,CTCL,HES,LAML,MPD | | 15805263;16007127;16034466;16091753;16424865;16564930;18594780;22288769;23400675;23701125;28671688;29279377 |
FGFR1 | MYO18A | t(8;17)(p11;q11) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 15800673 |
EWSR1 | POU5F1 | t(6;22)(p21;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | CESC,HNSC,KIRC,SARC,SKCM | | 15729702;18338330;20815032;21962892 |
EML1 | ABL1 | t(9;14)(q34;q32) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1 | ALL,alltypes | ALL | | 15713800 |
NUP214 | ABL1 | ins(2;9)(q23-24;q34q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1;NUP214 | ALL,alltypes | ALL | | 15674415 |
FUS | CREB3L1 | t(11;16)(p11;p11) | Eribulin | druggable | FUS | SARC | SARC | | 15640831;17721195 |
KMT2A | TIRAP | del(11)(q23q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 15626757 |
KMT2A | SMAP1 | t(6;11)(q13;q23) | Daunorubicin | druggable | KMT2A | LAML | CML,LAML | | 15626757;23628958 |
KMT2A | ACACA | t(11;17)(q23;q12) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 15626757;16897742;23628958 |
KMT2A | EEFSEC | t(3;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,CML,LAML | | 15626757;23628958 |
ETV6 | FRK | t(6;12)(q22;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 15611931 |
TRIM24 | FGFR1 | t(7;8)(q34;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | LAML,MPD,NEC | | 15609342 |
FGFR1 | MYO18A | t(8;17)(p11.2;q11.2) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 15582604;15800673;15835906 |
CCDC88C | PDGFRB | t(5;14)(q33;q32) | Imatinib | druggable | PDGFRB | MPD | MPD,NEC | | 15496975 |
PDGFRB | CCDC88C | t(5;14)(q32;q32) | Imatinib | druggable | PDGFRB | MPD | HES,MPD | | 15496975;24772479 |
TP53BP1 | PDGFRB | t(5;15)(q32;q15) | Imatinib | druggable | PDGFRB | MPD | MPD | | 15492236 |
KMT2A | ARHGAP26 | ins(5;11)(q31;q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 15382263 |
NUP214 | ABL1 | r(9)(q34q34) | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib | druggable | ABL1;NUP214 | ALL,alltypes | ALL | | 15361874;16873673;18987655 |
KMT2A | SARNP | t(11;12)(q23;q13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 15284855 |
FGFR1OP2 | FGFR1 | ins(12;8)(p11;p11p22) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | LAML,MPD | | 15034873 |
FGFR1 | FGFR1OP2 | t(8;12)(p12;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,DLBC | DLBC,MPD | | 15034873 |
KMT2A | SEPTIN11 | t(4;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | | 14999297;20633769;23628958 |
NGB | BCL2 | t(14;18)(q32;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | | 14987231 |
DAB2IP | KMT2A | t(9;11)(q33.1;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 14978793 |
DAB2IP | KMT2A | t(9;11)(q33;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 14978793 |
MECOM | CDK6 | t(3;7)(q26;q21) | Palbociclib | druggable | CDK6 | LAML | LAML | | 14551738;15322764;22887804 |
PDE4DIP | PDGFRB | t(1;5)(q21;q32) | Imatinib | druggable | PDGFRB | MPD | MPD | | 12907457 |
ERBB2 | PPP1R1B | t(17;17)(q12;q12) | Afatinib;Lapatinib;Sapitinib;Trastuzumab | druggable | ERBB2 | BLCA,COADREAD,KIRC,LUAD,OV,PAAD,PRAD,STAD | BLCA,CESC,COADREAD,KIRC,KIRP,LUAD,OV,PAAD,PRAD,STAD | | 12883659;24276243;25204415;25500544;26360582 |
MYH9 | ALK | t(2;22)(p23;q11.2) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL,NEC | | 12800156 |
ALK | MYH9 | t(2;22)(p23;q12) | Ceritinib;Crizotinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib | druggable | ALK | alltypes,COADREAD,LUAD,OV,PAAD,PRAD,STAD | CESC,COADREAD,CTCL,LUAD,OV,PAAD,PRAD,STAD | | 12800156;24564548 |
RANBP2 | ALK | t(2;2)(p23;q13) | Ceritinib;Crizotinib | druggable | ALK | alltypes,DLBC,IMT | CLL,CML,DLBC,IMT | | 12661011;18701132;20428197;24470379;24875859;26647767 |
ETV6 | PER1 | t(12;17)(p13;p13) | Midostaurin | druggable | ETV6 | LAML | LAML,NEC | | 12661008 |
GOPC | ROS1 | del(6)(q22q22) | Crizotinib | druggable | ROS1 | alltypes,GBM,LGG | GBM,LGG | | 12661006;28387643 |
KMT2A | ZFYVE19 | t(11;15)(q23;q14-15) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 12618766 |
KMT2A | KNL1 | t(11;15)(q23;q14-15) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 12618766 |
IGH | FGFR3 | del(17)(p13p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | MM | | 12576322;15976175;15990862;16030187;16511510;16826223;17024116;17209057;17854306;18046451;18173551;18418408;19324902;19332768;20072152;20537706;20721886;20739955;21523726;21685472;21836613;21900193;22234687;22426624;22547600;22641455 |
KMT2A | LASP1 | t(11;17)(q23;q12-21) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 12527918;16897742 |
KMT2A | LASP1 | t(11;17)(q23;q12) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 12527918;16897742 |
KMT2A | AFF4 | t(5;11)(q31;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 12399976;23628958 |
ERVK3-1 | FGFR1 | t(8;19)(p11;q13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 12393597 |
MTAP | CDKN2A | del(9)(p21.3) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 12228235 |
CDKN2A | CDKN2B | del(9)(p21.3) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 12228235 |
PAX3 | FOXO4 | t(X;2)(q13;q36) | Bortezomib | druggable | PAX3 | SARC | SARC | | 12183429 |
CARS | ALK | t(2;11)(p23;p15) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | IMT,NEC | | 12112524;12661011;13679433 |
RNF213 | ALK | t(2;17)(p23;q25) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL,NEC | | 12112524 |
IGH | FGFR3 | del(13)(q14q14) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | ALL,MM | | 11877296;12149226;12176874;12576322;15990862;16030187;16511510;16826223;16996589;17024116;17209057;17854306;18173551;18418408;19332768;20072152;20537706;20721886;20739955;21523726;21685472;21900193;22426624;22547600;22641455 |
IGH | FGFR3 | der(14)(q32) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | ALL,MM | | 11877296;15990862 |
ETV6 | FGFR3 | t(4;12)(p16;p13) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | CTCL,NEC | | 11731410 |
FGFR1 | CNTRL | t(8;9)(p11;q34) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | | | 11550283 |
CPSF6 | FGFR1 | t(8;12)(p12;q15) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | NEC | | 11550283;18205209 |
CLTC | ALK | t(2;17)(p23;q23) | Ceritinib;Crizotinib | druggable | ALK;CLTC | alltypes,DLBC,IMT | CTCL,DLBC,IMT,NEC | | 11485898;12112524;12661011;12750159;12763927;12920229;15492998;17656252;24875859;26647767 |
KMT2A | FNBP1 | ins(11;9)(q23;q34q34) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11438682 |
FNBP1 | KMT2A | ins(11;9)(q23;q34)inv(11)(q13q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11438682 |
FNBP1 | KMT2A | t(9;11)(q34;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11438682;23628958 |
KMT2A | LPP | t(3;11)(q28;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11433529 |
KMT2A | GPHN | t(11;14)(q23;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11289145;11579461 |
KMT2A | GPHN | t(11;14)(q23;q24) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11289145;11579461 |
ETV6 | SYK | t(9;12)(q22;p12) | Imatinib;Nilotinib | druggable | ETV6 | MPD | MPD | | 11159536 |
SYK | ETV6 | t(9;12)(q22;p13) | Imatinib;Nilotinib | druggable | ETV6 | MPD | ALL,MPD | | 11159536;22373549 |
ERVK3-1 | FGFR1 | t(8;19)(p12;q13) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | LAML | | 11122115;12393597 |
KMT2A | KNL1 | t(11;15)(q23;q15) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | | 10980622;12618768;16511515;23628958;24425691 |
EWSR1 | FEV | t(2;22)(q36;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 10976720;11854596;17690209 |
EWSR1 | PATZ1 | inv(22)(q12q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 10949935 |
ZBTB16 | RARA | ins(11;17)(q23;q21q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 10942371 |
ETV6 | ARNT | t(1;12)(q21;p13) | Midostaurin | druggable | ETV6 | LAML | ALL,LAML | | 10829078;20804916 |
ALK | CLTCL1 | t(2;22)(p23;q11.2) | Ceritinib;Crizotinib | druggable | ALK | alltypes | NEC | | 10807789;11090048 |
CLTCL1 | ALK | t(2;22)(p23;q11) | Ceritinib;Crizotinib | druggable | ALK | alltypes | CTCL | | 10807789 |
HRH4 | RET | t(10;18)(q11;q11-23) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 10741739;11156407 |
RET | KTN1 | t(10;14)(q11;q22) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | | 10741739;10850414 |
KMT2A | RARA | t(11;17)(q23;q12) | Daunorubicin;ATRA + arsenic trioxide | druggable | KMT2A;RARA | LAML | LAML | | 10720155 |
KMT2A | MLLT11 | t(1;11;4)(q21;q23;p16) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 10700861 |
CNTRL | FGFR1 | t(8;9)(p12;q33) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR1 | alltypes | MPD | | 10688839;11550283;11919391;12094244 |
FGFR1 | CNTRL | t(8;9)(p11;q33) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | LAML,MPD | | 10688839;11550283;18096225 |
KMT2A | ARHGEF12 | del(11)(q23q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | | 10681437;16341046 |
KMT2A | NCKIPSD | t(3;11)(p21;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 10648423 |
IGK | CDK6 | t(2;7)(p12;q21) | Palbociclib | druggable | CDK6 | DLBC | CLL,DLBC | | 10597225;12900351 |
IGK | CDK6 | t(2;7)(p11;q21) | Palbociclib | druggable | CDK6 | DLBC | CLL,DLBC | | 10597225;12900351;23127611 |
CDK6 | SEMA4F | t(2;7)(p11;q22) | Palbociclib | druggable | CDK6 | DLBC | DLBC | | 10597225 |
ETV6 | ABL2 | t(1;12)(q25;p13) | Midostaurin | druggable | ETV6 | LAML | ALL,LAML | | 10590083;10706884;22373549 |
KMT2A | AFF4 | ins(5;11)(q31;q13q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 10588740;12759932 |
HSP90AA1 | BCL6 | t(3;14)(q27;q32) | Luminespib | druggable | HSP90AA1 | DLBC,STAD | DLBC,MPNST,NEC,STAD | | 10564588;10811103;14655758;16772602 |
NUP98 | TOP1 | t(11;20)(p15;q12) | Camptothecin;Irinotecan | druggable | TOP1 | LAML | ALL,LAML,MPD | | 10556215;10959088;11979559;12645654;12874791;15036893;15100157;15390187;15951287;16467868;21813447 |
CHIC2 | ETV6 | t(4;12)(q11-q12;p13) | Midostaurin | druggable | ETV6 | LAML | LAML | | 10477709 |
FEV | EWSR1 | t(2;22)(q35;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 10451705;10976720;11406651;11854596;17690209 |
STAT5B | RARA | t(17;17)(q21;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML,NEC | | 10441338;18221386 |
TRIM24 | RET | t(7;10)(q34;q11.21) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 10439047;10741739;25204415;26800124 |
TRIM33 | RET | t(1;10)(p13;q11) | Cabozantinib;Vandetanib | druggable | RET;TRIM33 | LUAD | CESC,COADREAD,KIRP,LUAD,LUSC,OV,PAAD,PRAD,STAD | | 10439047;10741739;23533264;25079552;25204415;25500544 |
TRIM24 | RET | t(7;10)(q34;q11) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 10439047;10741739 |
KMT2A | SEPTIN9 | t(11;17)(q23;q25) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | | 10339604;10485469;12095151;16897742;17250889;18642054;20113838;20682395;23628958 |
ERC1 | RET | t(10;12)(q11;p13) | Cabozantinib;Vandetanib | druggable | RET | LUAD | CESC,COADREAD,KIRP,LUAD,OV,PAAD,PRAD,STAD | | 10337992;10741739;25204415 |
KMT2A | ARHGAP26 | t(5;11)(q31;q23) | Daunorubicin | druggable | KMT2A | LAML | CLL,CML,LAML,NEC | | 10206463;10400190;10908648;15852479 |
ETV6 | CDX2 | t(12;13)(p13;q12) | Midostaurin | druggable | ETV6 | LAML | LAML | | 9920852 |
ATIC | ALK | inv(2)(p23q35) | Ceritinib;Crizotinib | druggable | ALK | alltypes,IMT | CTCL,HL,IMT,NEC | | 10552961;10702393;10706082;10706887;10994999;11395396;12939746;9763551 |
ETV6 | PTPRR | inv(12)(p13q15) | Midostaurin | druggable | ETV6 | LAML | LAML,NEC | | 16061641;9694736 |
KMT2A | ABI1 | t(10;11)(p11.2;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11477655;12547160;9694699 |
KMT2A | ABI1 | t(10;11)(p12;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 11477655;12547160;16511515;23628958;9694699 |
KMT2A | SEPTIN5 | t(11;22)(q23;q11) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 11170279;23628958;23725386;9600980 |
KMT2A | SEPTIN5 | t(11;22)(q23.3;q11.2) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 9600980 |
STYXL1 | BCR | t(7;22)(q11.23;q11.23) | Nilotinib;Imatinib;TKIs;Bosutinib;Dasatinib;Ponatinib;Sorafenib | druggable | BCR | alltypes,CML | CML | | 9536079 |
ETV6 | CDX2 | t(12;13)(p12;q12-14) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | ALL,CML,LAML,MPD | | 10379868;9454771;9920852 |
MNX1 | ETV6 | t(7;12)(q36;p13) | Midostaurin | druggable | ETV6 | LAML | LAML,NEC | | 11066076;11417477;11454678;12939747;16646086;17960638;18940475;20596032;23531517;9454771;9523197 |
ZMYM2 | FGFR1 | t(8;13)(p11;q11-12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,DLBC,LAML | DLBC,LAML,MPD | | 9425908;9499416 |
ZMYM2 | FGFR1 | t(8;13)(p11;q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | ALL,LAML,MPD,NEC | | 17321332;22030335;23594707;25563327;29119847;9425908;9499416;9716603;9889006 |
ZMYM2 | FGFR1 | t(8;13)(p12;q12) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,DLBC | ALL,CTCL,DLBC,MPD | | 10480903;10887137;10935490;9376594;9425908;9576949;9716603;9889006 |
PDGFRB | TRIP11 | t(5;14)(q32;q32) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | LAML | LAML | | 22570408;9373237 |
KMT2A | FOXO3 | t(6;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 18932267;23628958;9345057;9624533 |
ETV6 | JAK2 | t(9;12)(p24;p13) | Midostaurin;Ruxolitinib;Pembrolizumab | druggable | ETV6;JAK2 | LAML,ALL,alltypes | ALL,CML,LAML | | 22373549;9326218;9360930 |
KMT2A | CREBBP | t(11;16)(q23;p13.3) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,MPD | | 12956443;15334549;16843104;9226152 |
IGH | FGFR3 | t(4;14)(p16;q32) | AZD4547;BGJ398;Debio1347;Erdafitinib | druggable | FGFR3 | alltypes | ALL,CLL,MM,NEC | | 10397739;10493504;10945609;11510469;11877296;12149226;12176874;12576322;15015970;15761022;15976175;15990862;16030187;16129840;16129847;16511510;16826223;16996589;17024116;17209057;17460451;17625611;17805328;17854306;18046451;18173551;18418408;18676019;19324902;19332768;20072152;20410185;20537706;20620602;20721886;20739955;21261498;21523726;21685472;21836613;21900193;22023516;22234687;22426624;22547600;22641455;25441688;25812994;29196615;9207791;9354676;9865713 |
KMT2A | CREBBP | t(11;16)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | ALL,CML,LAML,MPD | | 10679915;10706136;9166831;9226152;9238046;9290955 |
CHIC2 | ETV6 | t(4;12)(q12;p13) | Midostaurin | druggable | ETV6 | LAML | ALL,DLBC,LAML | | 10477709;11861295;15759035;16224488;26728794;9130613 |
KMT2A | SH3GL1 | t(11;19)(q23;p13) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 10764144;10816441;9122235 |
FEV | EWSR1 | t(2;21;22)(q23;q22;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 9121764 |
EWSR1 | FEV | t(2;21;22)(q35;q22;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 9121764 |
CENPK | KMT2A | t(5;11)(q12;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 8950979 |
ETV6 | PDGFRA | t(4;12)(q12;p13) | Imatinib | druggable | PDGFRA | HES | HES,NEC | | 12023981;17555450;20107158;8639906 |
TRD | CDKN2A | t(9;14)(p21;q11) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 8631023 |
KMT2A | SEPTIN5 | t(11;22)(q23;q11.2) | Daunorubicin | druggable | KMT2A | LAML | LAML | | 8616037;9529125;9600980;9611266 |
ETV6 | MECOM | t(3;12)(q26;p13) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | CML,LAML,MPD | | 10979219;11835339;28182364;8547101;8695816;9044825 |
ZBTB16 | RARA | t(11;17)(q23;q21.1) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 8384553 |
FOXO4 | KMT2A | t(X;11)(q13;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 21900057;24367274;8378328;9010221 |
MDS2 | ETV6 | t(1;12)(p36;p13) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | LAML,MPD | | 12203785;8302728 |
FUS | MARS | t(12;16)(q13;p11) | Eribulin | druggable | FUS | SARC | SARC | | 7987849 |
KMT2A | ARHGEF17 | t(11;11)(q13;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | | 15867425;16511515;7934159 |
ETV6 | FLT3 | t(12;13)(p13;q12) | Midostaurin;Imatinib;Nilotinib;Cediranib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | druggable | ETV6;FLT3 | LAML,MPD | ALL,LAML,MPD | | 11078497;16761019;17268528;23703854;7861615;9454771;9523197 |
PAX3 | TPT1 | t(2;13)(q35;q14) | Bortezomib | druggable | PAX3 | SARC | SARC | | 7782066 |
ETV6 | PDGFRB | t(5;12)(q32;p13) | Midostaurin;Imatinib;Nilotinib;Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | ETV6;PDGFRB | LAML,MPD | ALL,CML,HES,LAML,MPD | | 16938578;17122866;20107158;21350831;22162288;27428428;27824051;7742547;8168137 |
ETV6 | PDGFRB | t(5;12)(q33;p13) | Imatinib;Nilotinib | druggable | ETV6;PDGFRB | MPD | CML,MPD,NEC | | 15350308;7742547;8168137;8689343 |
ETV6 | GOT1 | t(10;12)(q24;p13) | Midostaurin;Imatinib;Nilotinib | druggable | ETV6 | LAML,MPD | CML,LAML,MPD | | 16757412;18310541;7742547;9408758 |
EWSR1 | ETV1 | t(7;22)(p21;q12) | Mithramycin;Dactinomycin;Temozolomide;Arsenic trioxide;Figitumumab;Ifosfamide;Vincristine;Olaparib;PARP inhibitors;HCI2509;Doxorubicin;Etoposide;YK-4-279;Actinomycin;Cytarabine;Midostaurin;Shikonin;Trabectedin;Gemcitabine;Docetaxel | druggable | EWSR1 | SARC | SARC | | 11391597;11406651;17690209;7700648 |
PDGFRB | TRIP11 | t(5;14)(q33;q32) | Cediranib;Dasatinib;Foretinib;Sorafenib | druggable | PDGFRB | LAML | LAML | | 7656202;9373237 |
KMT2A | KNL1 | t(11;15)(q23;q14) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | | 10980622;7630191;8025282 |
TRA | CDKN2A | t(9;14)(p21;q11) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | ALL | | 28671688;7624129 |
FOXO4 | KMT2A | t(X;11)(q13.1;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML | | 21900057;6962201;7529552;8378328;9010221 |
FGFR1OP | FGFR1 | t(6;8)(q27;p11) | AZD4547;BGJ398;Debio1347;Erdafitinib;AZD-4547;Cediranib;Foretinib;PD-173074 | druggable | FGFR1 | alltypes,LAML | ALL,CML,LAML,MPD | | 11550283;11919389;12969958;15570299;28671687;6590932;7564500;9484786;9949182 |
KMT2A | SEPTIN2 | t(2;11)(q37;q23) | Daunorubicin | druggable | KMT2A | LAML | LAML,NEC | | 16682951;17574968;23628958;3855693 |
PDE4DIP | PDGFRB | t(1;5)(q21.2;q33) | Imatinib | druggable | PDGFRB | MPD | ALL,MPD | | 12907457;3663504;8646739 |
ZBTB16 | RARA | t(11;17)(q23;q21) | ATRA + arsenic trioxide | druggable | RARA | LAML | LAML | | 10500192;10942370;16897742;2790765;7517211;7849296;8384553;8387545;8819070;8952164;9389704 |
KMT2A | MLLT11 | t(1;11)(q21;q23) | Daunorubicin | druggable | KMT2A | LAML | ALL,LAML,NEC | | 10025907;10700861;16511515;22854283;23628958;2702626;7833468 |
BCL2 | IGL | t(18;22)(q21;q11) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | CLL,DLBC | | 18656237;1992441;2506501;2704746 |
BCL2 | IGK | t(2;18)(p11;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | CLL,DLBC | | 1899478;2043472;8204892;9747876 |
IGK | BCL2 | t(2;18)(p12;q21) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | CLL,DLBC | | 1899478;2043472;8204892;9747876 |
NOTCH1 | TRB | t(7;9)(q34;q34) | Gamma secretase inhibitors | druggable | NOTCH1 | ALL | ALL | | 15674412;1831692;2962650 |
IGHV4-59 | BCL2 | t(14;18)(q32;q21.3) | ABT-737;Navitoclax;Obatoclax Mesylate;Sabutoclax;Venetoclax | druggable | BCL2 | DLBC | DLBC | | 1562734;15668700 |
SET | NUP214 | del(9)(q34q34) | Imatinib | druggable | NUP214 | ALL | ALL,LAML | | 1384675;15239126;17296573;17620317;18299449;19166587;20682390;21679311;24449214;8895527 |
FOXO1 | ATIC | t(2;13)(q35;q14) | Bortezomib | druggable | FOXO1 | SARC | SARC | | |
CDKN2A | FAM230A | t(9;22)(p21;q11.2) | Abemaciclib;Palbociclib;Ribociclib | druggable | CDKN2A | alltypes | SKCM,UVM | | |
KMT2A | TMX2-CTNND1 | t(11)(q23) | Daunorubicin | druggable | KMT2A | LAML | LAML | | |
KIAA1549 | BRAF | | Cobimetinib;PLX8394;Dabrafenib;PLX-4720;Vemurafenib;MEK inhibitors;Sorafenib;Dabrafenib+Trametinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | predicted | BRAF | | | AM989472;AM989475;AM989477;AM989474;AM989473;AM989476;FR799514;FR799529;FR799522;FR799548;FR799513;FR799546;FR799518;FR799524;FR799532;FR799542;FR799523;FR799525;FR799537;FR799541;FR799549;FR799516;FR799520;FR799533;FR799534;FR799521;FR799526;FR799512;FR799535;FR799543;FR799550 | 20454969;21610142;22157620;12661006;12656747;12041680;12900351;12823349;15262440;15721642;11530806;16737907;17981222;17998637;17987804;18083107;17320954;18553081;19215799;19373855;19480935;19565180;20682400;21279819;21325259;19016743;21281226;21338279;22018274;3179449;2357696;2201832;2237408;2013978;1958592;8453594;7596189;7658716;8697423;8632661;8656674;8956878;8982045;9389705;9666810;10549273;10640151;10918240;12165445;12547154;18347292;16924701;18074781;16393682;12114534;9494617;10616282;17349636;12196931;17382013;11341993;9665193;7769849;11241795;7599321;18722880;18555525;16888785;17645839;11378554;16961463;15254401;12028029;18533795;17493320;9067577;11072027;12173041;19145090;7996873;11684281;16224485;16928319;11409908;16891454;16800946;9648560;16029627;17696194;19182535;11640869;15000831;16383241;11852587;10674911;7938018;16843101;16334201;19157547;10648600;10965782;8896419;14625174;10822991;11905088;8061892;14635607;7866899;10794714;15228654;16409301;16129042;10627442;17470736;16023722;8734143;18418407;16904383;18429957;9269756;11783955;16251025;7845006;10998848;11766332;19199263;18283861;16204063;7718886;16468653;8629106;7703041;11708318;12755554;11574931;17382020;7662984;19343297;12002774;19388595;15650267;16755775;14725895;18190961;16209886;16258220;11255271;7524618;16800914;10905245;17292736;8685681;9376661;11876951;8649049;15014529;10602411;15820950;15899391;16254181;16950675;18766960;16305489;10068681;12023981;18578373;15377489;10576511;17566666;8025286;10526530;17146202;9858233;8822944;16960151;10751535;14657955;17245764;17875506;16284673;16024645;11036109;8417787;9593785;15739279;11976731;11979553;18759727;8165000;18438408;14734089;7723412;15255169;17286448;19194200;17168670;7885040;10931454;17218393;9207464;9168433;14575547;11091204;16341034;12067277;17197751;17688365;18708370;8747994;16475128;7596151;9710720;16203604;8414522;11154991;11237066;16207215;16923568;14677715;16689455;11734316;8562932;7600533;10637493;11919387;17493325;15087031;17106019;18417213;18250304;11028176;8932497;15271392;11130241;18262055;10459357;3460176;8807132;10674025;17638851;11284030;8207957;19136943;15262435;18603893;18094559;8607028;11697648;18696070;17459201;7947289;10632353;10500825;15355693;8231240;8659451;16598834;16631477;11504279;17452251;14678896;16129041;19097599;7937723;14505550;8697426;10731584;7564157;15248918;11114705;16682291;9087799;10947902;19141860;8035612;14635208;9844930;16228048;18426313;16144796;17504122;9809034;19067742;15978941;15356652;16780770;15579919;11754648;18467025;11841409;11126203;16638190;17490540;16403254;8062887;8767524;15791812;15987013;10214860;17402211;15789779;11114130;17914187;7701917;16502578;18566539;15277706;15475075;16875579;14689877;18672441;10431169;15027317;16772122;16490599;16403263;15042680;14966468;18445043 |
BCR | ABL1 | | Imatinib;Dasatinib;Nilotinib;Ponatinib;Bosutinib;Asciminib;AZD0530;Ruxolitinib;TKIs;Sorafenib | predicted | ABL1;BCR | | | DQ898314;M25946;AF487522;DQ912588;DQ898313;EU236680;M19730;AM491360;S72478;AJ131466;EF423615;AM491359;S72479;EU216070;AM491361;AM491363;AY043457;X07537;DQ912589;AJ131467;EU216071;EU216064;AM491362;AF113911;X06418;DQ912590;EU216066;AF533988;AY789120;JQ425238;JQ425243;U19408;JQ425244;JQ425252;JQ425250;JQ425253;U19399;JQ425249;JQ425248;U19400;AM886138;JQ425239;AM600680;AM400881;JQ425245;JQ425240;AB069693;JQ425241;U19406;EU447303;EU216059;EU394717;EF158045;EU394716;M13096;KU234180;FN820252;FN820219;FN820245;FN869153;FN869160;FN869168;FN869173;FN820215;FN820216;FN820218;FN820224;FN869133;FN869148;FN869151;FN869157;FN869164;FN869171;FN820212;FN820213;FN820222;FN869147;FN820221;FN820229;FN820230;FN820232;FN820261;FN869152;FN869159;FN869163;FN869166;FN869176;FN820207;FN820238;FN820239;FN820242;FN820249;FN820250;FN820251;FN820257;FN820258;FN820264;FN869132;FN869135;FN869146;FN820225;FN869161;FN869162;FN869165;FN869174;FN869175;FN820209;FN820247;FN820263;FN820208;FN820210;FN820223;FN820237;FN820243;FN820246;FN820248;FN869138;FN869140;FN869143;FN869145;FN869149;FN869172;FN820226;FN820228;FN820231;FN820233;FN820235;FN820236;FN820240;FN820217;FN820227;FN820255;FN820262;FN820266;FN820267;FN869136;FN869141;FN869144;FN869169;KR092001;KR092008;KR092011;KR092017;KR092019;KR092023;KR091996;KR091999;KR092003;KR092005;KR092010;KR092024;KR091983;KR091984;KR091990;KR092020;KR091981;KR091993;KR091995;KR091998;KR092000;KR091985;KR091989;KR091991;KR091994;KR092006;KR092018;KR091992;KR092022;KR091980;KR092004;KR092009;KR092015;KR092016;KR091987;KR091997;KR092012;KR092014;KR092002;KR092007;KR091986;KR091988;KR092013;M31759;M19695;KU705509;AF192533;M17541;MH743144;DQ898315;KU705510;KT696168;KU375572;EU216060;FN869156;FN820244;FN869142 | 12759927;12716364;12835719 |
RPS6KB1 | VMP1 | dup(17)(q23q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21467264 |
IGH | CDK6 | t(7;14)(q21;q32) | Palbociclib;Ribociclib | predicted | CDK6 | | CLL | | 12900351 |
ITK | SYK | t(5;9)(q33;q22) | Entospletinib;PRT062607 | predicted | SYK | | NEC,CTCL | | 16341044;24076779;19295409 |
PPP2R2A | CHEK2 | t(8;22)(p21;q12) | AZD-7762;MK-8776 | predicted | CHEK2 | | TGCT | | 16790090 |
SPTBN1 | FLT3 | t(2;13;2;21)(p16;q12;q33;q12) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | CML | | 17764812 |
SRGAP3 | RAF1 | dup(3)(p25p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | LGG | FM209427 | 19373855;19363522 |
ROCK1 | CMKLR1 | t(12;18)(q23;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21625565 |
ERBB3 | CRADD | t(12;12)(q13;q22) | Sapitinib | predicted | ERBB3 | | SARC | | 21625565 |
RPS6KB1 | VMP1 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD,CESC,HNSC | | 22101766;21247443;25500544 |
RNF213 | ALK | | Crizotinib;Ceritinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib | predicted | ALK | | | | 12112524 |
LCK | TRB | t(1;7)(p35;q34) | Dasatinib | predicted | LCK | | ALL | | 1680958;1663780 |
CDK6 | TLX3 | t(5;7)(q35;q21) | Palbociclib;Ribociclib | predicted | CDK6 | | NEC,ALL | | 15334547;28671688 |
IGL | CDK6 | t(7;22)(q21;q11) | Palbociclib;Ribociclib | predicted | CDK6 | | CLL | | 12900351 |
SPTBN1 | FLT3 | t(2;13)(p16;q12) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | CML | | 17764812 |
TRB | LCK | t(1;7)(p34;q34) | Dasatinib | predicted | LCK | | ALL | | 1663780;8049439 |
BRAF | BRAF | dup(?)() | Cobimetinib;PLX8394;Dabrafenib;PLX-4720;Vemurafenib;MEK inhibitors;Sorafenib;Dabrafenib+Trametinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | predicted | BRAF | | LGG | BE083400;AW860004;AW859953 | 18974108 |
BRAF | BRAF | dup(?)() | Cobimetinib;PLX8394;Dabrafenib;PLX-4720;Vemurafenib;MEK inhibitors;Sorafenib;Dabrafenib+Trametinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | predicted | BRAF | | LGG | BE083400;AW860004;AW859953 | 18974108 |
BRAF | BRAF | dup(?)() | Cobimetinib;PLX8394;Dabrafenib;PLX-4720;Vemurafenib;MEK inhibitors;Sorafenib;Dabrafenib+Trametinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | predicted | BRAF | | LGG | BE083400;AW860004;AW859953 | 18974108 |
BRAF | BRAF | dup(?)() | Cobimetinib;PLX8394;Dabrafenib;PLX-4720;Vemurafenib;MEK inhibitors;Sorafenib;Dabrafenib+Trametinib;Trametinib;Binimetinib+Encorafenib;Cobimetinib+Vemurafenib;Binimetinib+Cetuximab+Encorafenib;Dabrafenib+Panitumumab+Trametinib;Panitumumab+Vemurafenib | predicted | BRAF | | LGG | BE083400;AW860004;AW859953 | 18974108 |
ALK | STRN | del(2)(p22p23),t(2;2)(p22;p23) | Crizotinib;Ceritinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib | predicted | ALK | | | KJ162576 | 24613930;24475247 |
ALK | RANBP2 | t(2;2)(p23;q12.3) | Crizotinib;Ceritinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib | predicted | ALK;RANBP2 | | | | 24613277;12661011;24034896 |
ROS1 | TPM3 | t(6;1)(q22;q21.2) | Crizotinib;Crizotinib (ALK/MET/ROS1 TKI);Entrectinib;Ceritinib | predicted | ROS1;TPM3 | | | AB795239;JB625501 | 22327623 |
CDK6 | HEPACAM2 | t(7;7)(q21.2;q21.3) | Palbociclib;Ribociclib | predicted | CDK6 | | | | 24764564;18497076 |
MGA | CDKN2A | t(15;9)(q15.1;p21.3) | Abemaciclib;Palbociclib;Ribociclib | predicted | CDKN2A | | | | 21150883 |
TPM1 | ALK | t(15;2)(q22.2;p23.2) | Crizotinib;Ceritinib;PF2341066;TAE684;novel ALK inhibiors;Alectinib;Brigatinib;Lorlatinib | predicted | ALK | | | | 27132509;26719536 |
RPS6KB1 | VMP1 | t(17;17)(q23.1;q23.1) | PF-4708671 | predicted | RPS6KB1 | | | | 21467264;26040699;26550473 |
TUBD1 | CDK12 | t(17;17)(q23.1;q12) | Cemiplimab;Nivolumab;Pembrolizumab | predicted | CDK12 | | | | 27488533 |
RPS6KB1 | TEX2 | t(17;17)(q23.1;q23.3) | PF-4708671 | predicted | RPS6KB1 | | | | 25100792;22895181 |
MTAP | CDKN2A | t(9;9)(p21.3;p21.3) | Abemaciclib;Palbociclib;Ribociclib | predicted | CDKN2A | | | | 11126361;26909863 |
RARA | CDK12 | t(17;17)(q21.2;q12) | ATRA + arsenic trioxide;Cemiplimab;Nivolumab;Pembrolizumab | predicted | RARA;CDK12 | | | | 24395524;25712099;26822576 |
ANK3 | CDK1 | t(10;10)(q21.2;q21.2) | Dinaciclib;RO-3306 | predicted | CDK1 | | | | 23237550 |
ERBB2 | SLC39A11 | t(17;17)(q12;q24.3) | Afatinib;Lapatinib;Sapitinib;Ado-Trastuzumab Emtansine;Lapatinib+Trastuzumab;Neratinib;Pertuzumab+Trastuzumab;Trastuzumab;Carboplatin-Taxol Regimen+Trastuzumab | predicted | ERBB2 | | | | 1351679;21247443;23259914 |
ROCK1 | LRIG3 | t(18;12)(q11.1;q14.1) | GSK269962A HCl | predicted | ROCK1 | | | | 25309904 |
RPS6KB1 | SNF8 | t(17;17)(q21;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | XX000001 | 21247443;22101766;21622959 |
LCLAT1 | ERBB4 | t(2;2)(p23;q34) | Afatinib;Lapatinib | predicted | ERBB4 | | MB | | 22832583 |
PRKDC | C8orf22 | t(8;8)(q11;q11) | NU7441 | predicted | PRKDC | | CESC,HNSC | | 22960745 |
GSK3B | IMPG2 | t(3;3)(q12;q13) | SB216763 | predicted | GSK3B | | CESC,HNSC | | 22960745 |
DIAPH3 | RPS6KB1 | t(13;17)(q21;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 21622959;22496636 |
PRELID2 | MAPK9 | t(5;5)(q32;q35) | Doramapimod | predicted | MAPK9 | | GBM,NB | | 23334666 |
PIK3CA | KCNMB3 | inv(3)(q26q26) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 23636398 |
FYCO1 | RAF1 | t(3;3)(p21;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | LGG | | 23583981 |
RAF1 | QKI | t(3;6)(p25;q26) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | LGG | | 23583981;28806393 |
YES1 | ENOSF1 | dup(18)(p11p11) | Dasatinib | predicted | YES1 | | DLBC | | 23699601 |
ERF | GSK3A | t(19;19)(q13;q13) | SB216763 | predicted | GSK3A | | LGG,GBM | | 23917401 |
HOXA11-AS | CDK6 | t(7;7)(p15;q21) | Palbociclib;Ribociclib | predicted | CDK6 | | ALL | | 24367274 |
CDK6 | RPL35P4 | t(7;7)(p15;q21) | Palbociclib;Ribociclib | predicted | CDK6 | | ALL | | 24367274 |
MAPK9 | UBL7 | t(5;15)(q35;q24) | Doramapimod | predicted | MAPK9 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD,CESC,HNSC | | 25500544 |
PRKDC | MYO5A | t(8;15)(q11;q21) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
ROCK1 | CABYR | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
TUBD1 | RPS6KB1 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;25204415 |
ROCK1 | GATA6 | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
LYN | TGS1 | t(8;8)(q12;q12) | Dasatinib | predicted | LYN | | MM,LGG | | 25500544;29196615 |
ROCK1 | DCC | t(18;18)(q11;q21) | GSK269962A HCl | predicted | ROCK1 | | CESC,HNSC | | 25500544 |
ERBB4 | ATAD2 | t(2;8)(q34;q24) | Afatinib;Lapatinib | predicted | ERBB4 | | CESC,HNSC | | 25500544 |
ROCK1 | B4GALT6 | t(18;18)(q11;q12) | GSK269962A HCl | predicted | ROCK1 | | CESC,HNSC | | 25500544 |
KCMF1 | PRKDC | t(2;8)(p11;q11) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
C1orf132 | RPS6KB1 | t(1;17)(q32;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
USP13 | PIK3CA | t(3;3)(q26;q26) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;23972288 |
TBL1XR1 | PIK3CA | t(3;3)(q26;q26) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;25204415;28783718 |
ROCK1 | ABHD3 | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
SLC39A14 | PRKDC | t(8;8)(p21;q11) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
AURKB | MYH10 | t(17;17)(p13;p13) | Tozasertib;ZM-447439 | predicted | AURKB | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PPP6R1 | AURKC | t(19;19)(q13;q13) | Tozasertib | predicted | AURKC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RPS6KB1 | RNF213 | t(17;17)(q23;q25) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PRKDC | CEP290 | t(8;12)(q11;q21) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
RPS6KB1 | EFCAB3 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
LRIG3 | ROCK1 | t(12;18)(q14;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
DDX42 | RPS6KB1 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544;25204415 |
RPS6KB1 | TEX2 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
GUCA2B | ROCK1 | t(1;18)(p34;q11) | GSK269962A HCl | predicted | ROCK1 | | BLCA,KIRC,KIRP | | 25500544 |
PRKDC | UBE2V2 | t(8;8)(q11;q11) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25500544 |
PIK3CA | TAF1D | t(3;11)(q26;q21) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | CESC,HNSC,KIRC,KIRP,LIHC,LUAD,LUSC,NSCLC,UCEC | | 26168399 |
FNDC3B | PIK3CA | t(3;3)(q26;q26) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 25204415 |
CLCN6 | RAF1 | t(1;3)(p36;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 25204415 |
LMNA | RAF1 | t(1;3)(q22;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 25204415 |
RAF1 | MPRIP | t(3;17)(p25;p11) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 25204415 |
TRAK1 | RAF1 | t(3;3)(p22;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 25204415;29099951 |
LYN | NCOR1 | t(8;17)(q12;p11) | Dasatinib | predicted | LYN | | ALL | | 26404892;27176795 |
BCL6 | RAF1 | t(3;3)(p25;q27) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | LGG,GBM | | 23637631 |
CDK6 | KMT2A | t(7;11)(q21;q23) | Palbociclib;Ribociclib;Daunorubicin | predicted | CDK6;KMT2A | | ALL | AF492830;AF492834 | 11930009 |
ETV6 | LYN | ins(12;8)(p13;q11q21) | Entrectinib;Midostaurin;Imatinib;Nilotinib;Dasatinib | predicted | ETV6;LYN | | | | 19710703 |
IKZF1 | CDK2 | t(7;12)(p12;q13) | Dinaciclib;MK-8776 | predicted | CDK2 | | ALL | | 27265895 |
ZMYM2 | FLT3 | t(13;13)(q12;q12) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | MPD,ALL | | 27824051;28751768 |
LYN | GATAD2A | t(8;19)(q12;p13) | Dasatinib | predicted | LYN | | ALL | | 27824051 |
CPQ | PRKDC | t(8;8)(q11;q22) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 26689674 |
MELTF | TNK2 | t(3;3)(q29;q29) | Dasatinib | predicted | TNK2 | | ALL,TGCT | | 27428428;29099951 |
CDK1 | DGKH | t(10;13)(q21;q14) | Dinaciclib;RO-3306 | predicted | CDK1 | | ALL | | 27428428 |
RAF1 | CDH3 | t(3;16)(p25;q22) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 28467829 |
RAF1 | GOLGA4 | t(3;3)(p22;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | SKCM,UVM | | 28467829 |
NFIA | RAF1 | t(1;3)(p31;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | LGG | | 27810072 |
TCF4 | ROCK1 | del(18)(q11q21) | GSK269962A HCl | predicted | ROCK1 | | MB | | 28726821 |
FLT3 | FLT3 | t(13;13)(q12;q12) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | LAML | | 28112737 |
CDK6 | NKX2-1 | t(7;14)(q21;q13) | Palbociclib;Ribociclib | predicted | CDK6 | | ALL | | 28671688 |
GOLGB1 | FLT3 | t(3;13)(q13;q12) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | MPD | | 27795560 |
FLT3 | TRIP11 | t(13;14)(q12;q32) | Cediranib;Sunitinib;Crenolanib;Gilteritinib;High Dose Chemotherapy+Midostaurin;Quizartinib;Sorafenib | predicted | FLT3 | | CTCL | | 29025582 |
NUAK1 | C12orf65 | t(12;12)(q23;q24) | WZ4003 | predicted | NUAK1 | | | | 29099951 |
NUAK1 | UHRF1BP1L | t(12;12)(q23;q23) | WZ4003 | predicted | NUAK1 | | | | 29099951 |
AURKC | PPP6R2 | t(19;22)(q13;q13) | Tozasertib | predicted | AURKC | | | | 29099951 |
PRKCA | RPS6KB1 | t(17;17)(q24;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PRKDC | CLVS1 | t(8;8)(q11;q12) | NU7441 | predicted | PRKDC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
PRKDC | CA3 | t(8;8)(q11;q21) | NU7441 | predicted | PRKDC | | MPNST | | 29099951 |
RAF1 | IQSEC1 | t(3;3)(p25;p25) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | BLCA,KIRC,KIRP | | 29099951 |
RAF1 | NXPH1 | t(3;7)(p25;p21) | Cobimetinib;MEK inhibitors;Sorafenib | predicted | RAF1 | | BLCA,KIRC,KIRP | | 29099951 |
RAI14 | MAPK9 | t(5;5)(p13;q35) | Doramapimod | predicted | MAPK9 | | SKCM,UVM | | 29099951 |
THNSL1 | ROCK1 | t(10;18)(p12;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ROCK1 | CHST9 | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ROCK1 | LAMA3 | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
ROCK1 | ANKRD29 | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
RNF38 | ROCK1 | t(9;18)(p13;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,HNSC | | 29099951 |
ROCK1 | LAMP5 | t(18;20)(q11;p12) | GSK269962A HCl | predicted | ROCK1 | | | | 29099951 |
FABP2 | ROCK1 | t(4;18)(q26;q11) | GSK269962A HCl | predicted | ROCK1 | | BLCA,KIRC,KIRP | | 29099951 |
ROCK1 | OSBPL1A | t(18;18)(q11;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MAP1B | ROCK1 | t(5;18)(q13;q11) | GSK269962A HCl | predicted | ROCK1 | | SKCM,UVM | | 29099951 |
ROCK1 | CDH2 | t(18;18)(q11;q12) | GSK269962A HCl | predicted | ROCK1 | | CESC,HNSC | | 29099951 |
RPS6KA2 | KIFC1 | t(6;6)(q27;p21) | LJI308 | predicted | RPS6KA2 | | | | 29099951 |
RPS6KA3 | KDM6A | t(X;X)(p22;p11) | LJI308;Tazemetostat | predicted | RPS6KA3;KDM6A | | | | 29099951 |
RPS6KB1 | FKBP10 | t(17;17)(q23;q21) | PF-4708671 | predicted | RPS6KB1 | | CESC,HNSC | | 29099951 |
TBL1XR1 | ROCK1 | t(3;18)(q26;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
TMEM200A | FYN | t(6;6)(q23;q21) | Dasatinib | predicted | FYN | | SKCM,UVM | | 29099951 |
TYMS | YES1 | t(18;18)(p11;p11) | Dasatinib | predicted | YES1 | | CESC,HNSC | | 29099951 |
BCAS3 | RPS6KB1 | t(17;17)(q23;q23) | PF-4708671 | predicted | RPS6KB1 | | CESC,HNSC | | 29099951 |
SCFD2 | YES1 | t(4;18)(q12;p11) | Dasatinib | predicted | YES1 | | BLCA,KIRC,KIRP | | 29099951 |
ZNF587 | AURKC | t(19;19)(q13;q13) | Tozasertib | predicted | AURKC | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
CDK2 | PAN2 | t(12;12)(q13;q13) | Dinaciclib;MK-8776 | predicted | CDK2 | | | | 29099951 |
FRK | SYT1 | t(6;12)(q22;q21) | Dasatinib | predicted | FRK | | | | 29099951 |
FYN | CDK19 | t(6;6)(q21;q21) | Dasatinib | predicted | FYN | | SKCM,UVM | | 29099951 |
GNE | ROCK1 | t(9;18)(p13;q11) | GSK269962A HCl | predicted | ROCK1 | | CESC,HNSC | | 29099951 |
AKT3 | HEATR1 | t(1;1)(q44;q43) | Afuresertib;AZD-5363;Ipatasertib;Uprosertib;ATP-competitive AKT inhibitors | predicted | AKT3 | | MESO | | 29099951 |
GSK3B | BEST3 | t(3;12)(q13;q15) | SB216763 | predicted | GSK3B | | | | 29099951 |
GSK3B | WNK2 | t(3;9)(q13;q22) | SB216763 | predicted | GSK3B | | MPNST | | 29099951 |
GTF2H3 | NUAK1 | t(12;12)(q24;q23) | WZ4003 | predicted | NUAK1 | | | | 29099951 |
PRKDC | KCNC3 | t(8;19)(q11;q13) | NU7441 | predicted | PRKDC | | CESC,HNSC | | 29099951 |
MAPK9 | DGKB | t(5;7)(q35;p21) | Doramapimod | predicted | MAPK9 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | | 29099951 |
MAPK9 | ZFP2 | t(5;5)(q35;q35) | Doramapimod | predicted | MAPK9 | | CESC,HNSC | | 29099951 |
MUC4 | TNK2 | t(3;3)(q29;q29) | Dasatinib | predicted | TNK2 | | CESC,HNSC | | 29099951 |
NCKAP5 | ERBB4 | t(2;2)(q21;q34) | Afatinib;Lapatinib | predicted | ERBB4 | | CESC,HNSC | | 29099951 |
FLT1 | STAU1 | t(13;20)(q12;q13) | Cediranib | predicted | FLT1 | | ALL | | 27903646 |
IGKV2D-30 | EIF2AK3 | t(2;2)(p11;p11) | GSK2606414 | predicted | EIF2AK3 | | ALL | | 27903646 |
PIK3CA | TNFSF10 | t(3;3)(q26;q26) | Alpelisib;Alpelisib+Fulvestrant;Buparlisib;Buparlisib+Fulvestrant;Copanlisib;Fulvestrant+Taselisib;GDC-0077;Serabelisib;Taselisib | predicted | PIK3CA | | MM | | 29196615 |
AKT1 | MTA1 | t(14;14)(q32;q32) | Afuresertib;AT-13148;AZD-5363;Ipatasertib;MK-2206;Uprosertib;AZD5363 | predicted | AKT1 | | MM | | 29196615 |
PRKDC | CPA6 | t(8;8)(q11;q13) | NU7441 | predicted | PRKDC | | MM | | 29196615 |
DENND11 | AGK | t(7;7)(q34;q34) | | predicted | AGK | | LAML | AA225538 | 23251452 |
MAP3K13 | RPL4 | t(3;15)(q27;q22) | | predicted | MAP3K13 | | MM | AA493539 | 29196615 |
KAT6A | IKBKB | t(8;8)(p11;p11) | | predicted | IKBKB | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AA502963 | 25220592;25500544 |
IRAK1 | MECP2 | t(X;X)(q28;q28) | | predicted | IRAK1 | | BLCA,KIRC,KIRP | AI022621 | 11689684;25500544 |
RACK1 | FER | t(5;5)(q21;q35) | | predicted | RACK1;FER | | MM | AI418079 | 29196615 |
ALPK2 | NEDD4L | t(18;18)(q21;q21) | | predicted | ALPK2 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | AI972351 | 29099951 |
UBTD2 | STK10 | t(5;5)(q35;q35) | | predicted | STK10 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BF383106 | 29099951 |
AKAP12 | ZBTB2 | t(6;6)(q25;q25) | | predicted | AKAP12 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BU585360 | 29099951 |
PAPOLA | AK7 | t(14;14)(q32;q32) | | predicted | AK7 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | BU944613 | 22101766;19592507;25500544;22952423 |
NDUFAF7 | PRKD3 | t(2;2)(p22;p22) | | predicted | PRKD3 | | LAML | CN354928 | 23251452 |
GUK1 | ARF1 | t(1;1)(q42;q42) | | predicted | GUK1 | | ALL | DA131615 | 24367274 |
AKAP9 | CDK14 | t(7;7)(q21;q21) | | predicted | AKAP9;CDK14 | | CESC,HNSC | DA807731 | 29099951 |
HIF1A | PRKCH | t(14;14)(q23;q23) | | predicted | PRKCH | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD,CESC,HNSC | DB202604 | 25500544 |
RACK1 | CTNNB1 | t(3;5)(p21;q35.3) | | predicted | RACK1 | | | DB330856 | 22240482 |
SCYL2 | DEPDC4 | t(12;12)(q23;q23) | | predicted | SCYL2 | | CESC,HNSC | EC450488 | 29099951 |
ACAD10 | MAPKAPK5 | t(12;12)(q24;q24) | | predicted | MAPKAPK5 | | LAML,MM | EC500789 | 23634996;29196615 |
ARFGAP3 | PACSIN2 | t(22;22)(q13;q13) | | predicted | PACSIN2 | | CESC,HNSC | EC546368 | 29099951;27058892 |
CACNA1I | TAB1 | t(22;22)(q13;q13) | | predicted | TAB1 | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | EC575276 | 25500544 |
DGKB | MIPOL1 | t(7;14)(p21;q13-21) | | predicted | DGKB | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | EU693080 | 19136943 |
TNPO1 | IKBKB | t(5;8)(q13;p11) | | predicted | IKBKB | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | HM245392 | 21036922 |
CDKN1A | CD9 | t(6;12)(p21;p13) | | predicted | CDKN1A | | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | HM245393 | 21036922 |
TNS3 | MAP3K3 | t(7;17)(p12;q23) | | predicted | MAP3K3 | | MESO | KP189193 | 25484136 |
RARA | PKIA | t(8;17)(q21;q21) | ATRA + arsenic trioxide | predicted | PKIA;RARA | LAML | CESC,COADREAD,LUAD,OV,PAAD,PRAD,STAD | XX000008 | 21247443 |